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ChemDiv3_013979 (CID 54689728) - Compound BioActivity Data
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BioActivity Outcomes:
Active(32)
 
 
Inactive(817)
 
 
Inconclusive(23)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
TRP 2(20)
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
BioAssay Types:
Screening(578)
 
 
 
 
 
Confirmatory(263)
 
 
 
 
 
Literature(7)
 
 
BioActivity Types:
Potency(165)
 
 
 
 
 
IC50(47)
 
 
 
EC50(22)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 808    Data Row: 875   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4263924]
EC50 3.419Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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2
[SID4263924]
EC50 3.536Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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3
[SID144220922]
EC50_Mean 5.68SAR analysis of small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format [AID651648, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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4
[SID144220922]
EC50_Mean 5.68SAR analysis of small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format [AID651648, Type: confirmatory]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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5
[SID4263924]
EC50_Mean 7.06Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex [AID602473, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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6
[SID4263924]
EC50_Mean 7.06Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex [AID602473, Type: confirmatory]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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7
[SID4263924]
Potency 7.9433qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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8
[SID4263924]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID4263924]
Potency 50.1187qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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10
[SID4263924]
EC50 54.952Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
View
11
[SID4263924]
Counter screen for compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID449723, Type: screening]
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12
[SID4263924]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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13
[SID4263924]
Screen for Chemicals that Inhibit the RAM Network [AID868, Type: screening]
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14
[SID4263924]
Human Endothelial Cell Proliferation Assay - Dose Response [AID822, Type: confirmatory]
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15
[SID4263924]
Antimicrobial Assay for E. coli BW25113 ∆tolC::kan - Dose Response [AID617, Type: confirmatory]
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16
[SID4263924]
Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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17
[SID4263924]
Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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18
[SID4263924]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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19
[SID4263924]
Confirmatory screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID2426, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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20
[SID4263924]
Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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21
[SID4263924]
Confirmatory screen for compounds that inhibit the Choline Transporter (CHT) [AID493221, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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22
[SID4263924]
Counter screen assay of the parental HEK293 cells for compounds that inhibit the Choline Transporter (CHT) [AID493222, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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23
[SID4263924]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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24
[SID4263924]
Primary cell-based screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID2237, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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25
[SID4263924]
Second counter screen for compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID434977, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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26
[SID4263924]
Inhibitors of Cav3 T-type Calcium Channels: Primary Screen [AID449739, Type: screening]voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] [gi:53832009]
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27
[SID4263924]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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28
[SID4263924]
Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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29
[SID4263924]
Re-confirmation screening for identification of compounds that activate MrgX1 receptor signaling [AID602412, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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30
[SID4263924]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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31
[SID4263924]
Specificity screen against TRPC6 for compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID434950, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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32
[SID4263924]
Counter-screen against parental HEK293 cells for identification of compounds that activate MrgX1 receptor signaling [AID624115, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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33
[SID4263924]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID4263924]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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35
[SID4263924]
Potency qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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36
[SID4263924]
Potency 2.8184qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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37
[SID4263924]
Potency 2.8184qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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38
[SID4263924]
Potency 14.1254qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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39
[SID4263924]
Potency 15.8489qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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40
[SID4263924]
Potency 22.3872qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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41
[SID4263924]
Potency 22.3872qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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42
[SID4263924]
EC50 150Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression [AID1914, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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43
[SID4263924]
Cathepsin G [AID581, Type: screening]Cathepsin G [Homo sapiens] [gi:15680217]
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44
[SID92189688]
A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus [AID720641, Type: other]anion-binding protein [Staphylococcus aureus subsp. aureus Mu50] [gi:15923709]
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45
[SID4263924]
uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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46
[SID4263924]
Primary Cell-Based Assay to Identify Agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1509, Type: screening]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
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47
[SID4263924]
Primary Cell-Based Assay to Identify Antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1510, Type: screening]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
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48
[SID4263924]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Escherichia coli DNA-binding ATP-dependent protease La (eLon) [AID602123, Type: screening]DNA-binding ATP-dependent protease La [Escherichia coli str. K-12 substr. MG1655] [gi:16128424]
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49
[SID4263924]
uHTS identification of MazEF TA System activators via a fluorescence-based single-stranded RNase assay [AID504720, Type: screening]mRNA interferase toxin, antitoxin is MazE [Escherichia coli str. K-12 substr. MG1655] [gi:16130689]
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50
[SID4263924]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) [AID651602, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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