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NSC5157 (CID 54688361) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(665)
 
 
Inconclusive(10)
 
 
Unspecified(10)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
7TM GPCR Srsx(17)
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(412)
 
 
 
 
Confirmatory(244)
 
 
 
 
Literature(21)
 
 
 
 
BioActivity Types:
Potency(137)
 
 
 
 
IC50(35)
 
 
 
EC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 631    Data Row: 689   Total Pages: 35   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26664481]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) [AID651572, Type: screening]ADP-ribosylation factor GTPase-activating protein 1 [Rattus norvegicus] [gi:21489979]
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2
[SID26664481]
Primary Cell-based High Throughput Screening Assay for Inhibitors of Wee1 Degradation [AID1321, Type: screening]WEE1 homolog (S. pombe) [Homo sapiens] [gi:47123300]
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3
[SID26664481]
Primary biochemical high-throughput screening assay to measure P97 ATPase inhibition [AID1481, Type: screening]Valosin-containing protein [Homo sapiens] [gi:111305821]
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4
[SID103543006]
Decrease in cdk4 protein level in in MCF7 cells at 200 uM after 18 hrs [AID303894, Type: Literature]
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5
[SID103543006]
Cell cycle arrest in MCF7 cells assessed as accumulation at S phase at 200 uM after 72 hrs by flow cytometry [AID303880, Type: Literature]
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6
[SID103543006]
Cell cycle arrest in MCF7 cells assessed as accumulation at G2/M phase at 200 uM after 72 hrs by flow cytometry [AID303881, Type: Literature]
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7
[SID103543006]
Cell cycle arrest in MCF7 cells assessed as accumulation at subG1 phase at 200 uM after 48 hrs by flow cytometry [AID303874, Type: Literature]
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8
[SID103543006]
Cell cycle arrest in MCF7 cells assessed as accumulation at G0/G1 phase at 200 uM after 48 hrs by flow cytometry [AID303875, Type: Literature]
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9
[SID103543006]
Cell cycle arrest in MCF7 cells assessed as accumulation at S phase at 200 uM after 48 hrs by flow cytometry [AID303876, Type: Literature]
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10
[SID103543006]
Cell cycle arrest in MCF7 cells assessed as accumulation at G2/M phase at 200 uM after 48 hrs by flow cytometry [AID303877, Type: Literature]
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11
[SID103543006]
Cell cycle arrest in MCF7 cells assessed as accumulation at subG1 phase at 200 uM after 72 hrs by flow cytometry [AID303878, Type: Literature]
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12
[SID103543006]
Cell cycle arrest in MCF7 cells assessed as accumulation at G0/G1 phase at 200 uM after 72 hrs by flow cytometry [AID303879, Type: Literature]
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13
[SID103543006]
Cytotoxicity against MCF7 cells assessed as cell viability at 200 uM after 72 hrs by MTT assay [AID303873, Type: Literature]
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14
[SID26664481]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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15
[SID26664481]
Potency 89.1251qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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16
[SID26664481]
Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK3 [AID602410, Type: screening]Kcnk3 channel [Homo sapiens] [gi:11093520]
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17
[SID26664481]
C. albicans biofilm killing---Mixture HTS [AID1242, Type: screening]glycosyl-phosphatidylinositol protein [Candida albicans] [gi:11094021]
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18
[SID26664481]
Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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19
[SID26664481]
Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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20
[SID26664481]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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