Clarithromycin (CID 54688) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(72)
 
 
Inactive(20)
 
 
Inconclusive(10)
 
 
Unspecified(252)
 
 
Top Targets:
ABC MTABC3 MD..(5)
 
 
p450(4)
 
 
7TM GPCR Srw(3)
 
 
 
7tm 2(2)
 
 
7TM GPCR Srx(1)
 
 
BioAssay Types:
Literature(336)
 
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 354    Data Row: 354   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103197283]
Reduction of pneumolysin production in Streptococcus pneumoniae NMU112 lysates at 5 ug/mL after 12 hrs by Western blot relative to control [AID326069, Type: Literature]
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2
[SID103197283]
Inhibition of pneumococcal surface protein A production in Streptococcus pneumoniae NMU112 lysates at 5 ug/mL after 12 hrs by Western blot relative to control [AID326071, Type: Literature]
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3
[SID103197283]
Antimicrobial activity against Streptococcus pneumoniae NMU112 infected in po dosed CBA/J mouse assessed as delaying in development of bacteremia relative to roxithromycin [AID326091, Type: Literature]
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4
[SID103197283]
Ratio of MIC for Campylobacter jejuni 001B-22 carrying A2075G mutation in 23S rRNA to MIC for Campylobacter jejuni 001B-22 cmeB::kanamycin-resistant mutant [AID369664, Type: Literature]
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5
[SID103197283]
Antimycobacterial activity against Mycobacterium ulcerans isolate CU001 infected in BALB/c mouse left hind foot-pad assessed as incidence of bacterial infection at 100 mg/kg, po administered for 5 days per week measured after 8 weeks [AID416846, Type: Literature]
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6
[SID103197283]
Antibacterial activity against extracellular Escherichia coli isolate HM605 isolated from colonic mucosal biopsies of patient with Crohn's disease at 0.01 to 10 ug/ml after 3 hrs [AID425596, Type: Literature]
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7
[SID103197283]
Antimicrobial activity against erythromycin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method [AID426375, Type: Literature]
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8
[SID103197283]
Antimicrobial activity against erythromycin-susceptible Streptococcus pneumoniae 07H252 by broth microdilution method [AID426376, Type: Literature]
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9
[SID103197283]
Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes 07U084 by broth microdilution method [AID426379, Type: Literature]
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10
[SID103197283]
Antimicrobial activity against erythromycin-susceptible Streptococcus pyogenes 07U086 by broth microdilution method [AID426380, Type: Literature]
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11
[SID103197283]
Fraction absorbed in human [AID444055, Type: Literature]
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12
[SID103197283]
Fraction escaping gut-wall elimination in human [AID444056, Type: Literature]
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13
[SID103197283]
Fraction escaping hepatic elimination in human [AID444057, Type: Literature]
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14
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae 4437 infected in mouse ddY assessed as decrease in total cell count in bronchoalveolar lavage fluid at 40 mg/kg, po bid for 3 days [AID496385, Type: Literature]
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15
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae 4437 infected in mouse ddY assessed as decrease in total cell count in bronchoalveolar lavage fluid at 100 mg/kg, po bid for 3 days [AID496386, Type: Literature]
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16
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae 4437 infected in mouse ddY assessed as decrease in neutrophil count in bronchoalveolar lavage fluid at 40 mg/kg, po bid for 3 days [AID496387, Type: Literature]
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17
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae 4437 infected in mouse ddY assessed as decrease in neutrophil count in bronchoalveolar lavage fluid at 100 mg/kg, po bid for 3 days relative to control [AID496388, Type: Literature]
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18
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae 4437 infected in mouse ddY assessed as decrease in IL1-beta level in bronchoalveolar lavage fluid at 100 mg/kg, po bid for 3 days relative to control [AID496390, Type: Literature]
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19
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae 4437 infected in mouse ddY assessed as decrease in MIP-2 level in bronchoalveolar lavage fluid at 40 mg/kg, po bid for 3 days relative to control [AID496391, Type: Literature]
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20
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae 4437 infected in mouse ddY assessed as decrease in MIP-2 level in bronchoalveolar lavage fluid at 100 mg/kg, po bid for 3 days relative to control [AID496392, Type: Literature]
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21
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae infected in mouse ddY assessed as inflammatory changes in lung at 40 mg/kg, po bid for 3 days relative to control [AID496393, Type: Literature]
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22
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae infected in mouse ddY assessed as inflammatory changes in lung at 100 mg/kg, po bid for 3 days relative to control [AID496394, Type: Literature]
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23
[SID103197283]
Antibacterial activity against macrolide-resistant Haemophilus influenzae 4437 infected in NCI-H292 cells assessed as decrease in viable bacterial count at 64 ug/ml by 3-h invasion assay [AID496395, Type: Literature]
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24
[SID103197283]
Antiinflammatory activity against nontypeable beta-lactamase-negative ampicillin-resistant Haemophilus influenzae 4437 infected in mouse ddY assessed as decrease in IL1-beta level in bronchoalveolar lavage fluid at 40 mg/kg, po bid for 3 days relative to control [AID496511, Type: Literature]
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25
[SID103197283]
Antibacterial activity against Helicobacter pylori Hp 26695 [AID502779, Type: Literature]
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26
[SID103197283]
Antibacterial activity against multidrug-resistant Helicobacter pylori v1354 [AID502781, Type: Literature]
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27
[SID103197283]
Antibacterial activity against Staphylococcus aureus ATCC 29213 assessed as bactericidal at 8 times MIC in 24 hrs by time kill study [AID524550, Type: Literature]
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28
[SID103197283]
Antimicrobial activity against Mycobacterium abscessus 390S infected in human monocyte-derived macrophage assessed as reduction in viable bacteria count at 10 times MIC by trypan blue exclusion assay [AID525097, Type: Literature]
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29
[SID103197283]
Bacteriostatic activity against Mycobacterium abscessus 390S infected in human monocyte-derived macrophage assessed as inhibition of planktonic cell growth at 4 ug/ml treated 24 hrs postinfection [AID525098, Type: Literature]
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30
[SID103197283]
Bacteriostatic activity against Mycobacterium abscessus 390R infected in human monocyte-derived macrophage assessed as inhibition of planktonic cell growth at 4 ug/ml treated 24 hrs postinfection [AID525099, Type: Literature]
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31
[SID103197283]
Bacteriostatic activity against Mycobacterium abscessus 390V infected in human monocyte-derived macrophage assessed as inhibition of planktonic cell growth at 4 ug/ml treated 24 hrs postinfection [AID525100, Type: Literature]
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32
[SID103197283]
Fraction unbound in human after iv administration [AID540211, Type: Literature]
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33
[SID103197283]
Antimicrobial activity against in Escherichia coli ATCC 25922 in presence of NAB741 [AID545918, Type: Literature]
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34
[SID103197283]
Antimicrobial activity against in Escherichia coli IH3080 in presence of NAB741 [AID545922, Type: Literature]
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35
[SID103197283]
Antimicrobial activity against in Klebsiella pneumoniae ATCC 13883 in presence of NAB741 [AID545926, Type: Literature]
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36
[SID103197283]
Antimicrobial activity against in Enterobacter cloacae ATCC 23355 in presence of NAB741 [AID545930, Type: Literature]
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37
[SID103197283]
Antimicrobial activity against in Acinetobacter baumannii ATCC 19606 in presence of NAB741 [AID545934, Type: Literature]
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38
[SID103197283]
Ratio of MIC for Acinetobacter baumannii ATCC 19606 to MIC for Acinetobacter baumannii ATCC 19606 in presence of 4 ug/ml of NAB741 [AID545939, Type: Literature]
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39
[SID103197283]
Antibacterial activity against Escherichia coli by CLSI method in presence of 2 mg/L tachyplesin 3 [AID553820, Type: Literature]
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40
[SID103197283]
Induction of erm(C) expression in Escherichia coli JM109 harboring Staphylococcus aureus erm(C)-containing pERMZalpha reporter plasmid at 8 mg/ml after 36 hrs at 37 degC by disc-based beta-galactosidase reporter gene assay [AID518967, Type: Literature]
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41
[SID103197283]
Antibacterial activity against Escherichia coli ATCC 25992 by Etest method in presence of NAB7061 [AID571200, Type: Literature]
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42
[SID103197283]
Antibacterial activity against Acinetobacter baumannii F264 by Etest method in presence of NAB739 [AID571211, Type: Literature]
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43
[SID103197283]
Antibacterial activity against Acinetobacter baumannii ATCC 19606 by Etest method in presence of NAB739 [AID571392, Type: Literature]
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44
[SID103197283]
Ratio of the MIC for Acinetobacter baumannii in the absence of NAB7071 to MIC for Acinetobacter baumannii in the presence of 4 ug/ml of NAB7071 [AID571661, Type: Literature]
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45
[SID103197283]
Ratio of the MIC for Serratia marcescens ATCC 8100 in the absence of NAB7072 to MIC for Serratia marcescens ATCC 8100 in the presence of 4 ug/ml of NAB7072 [AID571662, Type: Literature]
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46
[SID103197283]
Ratio of the MIC for Proteus mirabilis ATCC 29906 in the absence of NAB7073 to MIC for Proteus mirabilis ATCC 29906 in the presence of 4 ug/ml of NAB7073 [AID571663, Type: Literature]
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47
[SID103197283]
Ratio of the MIC for Proteus vulgaris ATCC 13315 in the absence of NAB7074 to MIC for Proteus vulgaris ATCC 13315 in the presence of 4 ug/ml of NAB7074 [AID571664, Type: Literature]
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48
[SID103197283]
Ratio of the MIC for Pseudomonas aeruginosa ATCC 27853 in the absence of NAB7075 to MIC for Pseudomonas aeruginosa ATCC 27853 in the presence of 4 ug/ml of NAB7075 [AID571665, Type: Literature]
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49
[SID103197283]
Ratio of MIC for Escherichia coli K-12 3-AG300 harboring acrB::rpsLneo mutant gene to MIC for Escherichia coli K-12 3-AG300 [AID571927, Type: Literature]
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50
[SID103197283]
Ratio of MIC for Escherichia coli K-12 3-AG300 harboring AcrB-615-628MexB mutant gene to MIC for Escherichia coli K-12 3-AG300 [AID571928, Type: Literature]
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