ST073166 (CID 54687868) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Inactive(455)
 
 
Inconclusive(3)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(18)
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
alkPPc(4)
 
 
KCNQ channel(4)
 
 
BioAssay Types:
Screening(318)
 
 
 
Confirmatory(134)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(99)
 
 
 
 
 
IC50(24)
 
 
AC50(5)
 
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 466    Data Row: 466   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49671450]
AC50 5.309Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick [AID488788, Type: confirmatory]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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2
[SID49671450]
AC50 5.309Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick [AID488788, Type: confirmatory]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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3
[SID49671450]
Potency 12.5893qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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4
[SID49671450]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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5
[SID49671450]
 Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID651616, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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6
[SID49671450]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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7
[SID49671450]
 Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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8
[SID49671450]
 Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting Enzyme [AID2563, Type: screening]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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9
[SID49671450]
 Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting Enzyme [AID2563, Type: screening]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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10
[SID49671450]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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11
[SID49671450]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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12
[SID49671450]
Potency 15.8489qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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13
[SID49671450]
Potency 89.1251qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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14
[SID49671450]
Potency 89.1251qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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15
[SID49671450]
Potency 100qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]MLL gene product [Homo sapiens] [gi:56550039]
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16
[SID49671450]
 Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]MLLT3 gene product [Homo sapiens] [gi:156104889]
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17
[SID49671450]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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18
[SID49671450]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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19
[SID49671450]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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20
[SID49671450]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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21
[SID49671450]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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22
[SID49671450]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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23
[SID49671450]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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24
[SID49671450]
Potency Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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25
[SID49671450]
Potency Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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26
[SID49671450]
Potency Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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27
[SID49671450]
Potency Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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28
[SID26535148]
 Cell-based luminescence-based Maybridge primary high throughput screening assay to identify agonists of NOTCH [AID434982, Type: screening]NOTCH 1 [Homo sapiens] [gi:11275980]
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29
[SID49671450]
Potency qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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30
[SID49671450]
 Image-Based HTS for Selective Agonists for NTR1 [AID493036, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
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31
[SID49671450]
 Image-Based HTS for Selective Agonists for NTR1 [AID493036, Type: screening]NTSR1 gene product [Homo sapiens] [gi:110611243]
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32
[SID49671450]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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33
[SID49671450]
 Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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34
[SID49671450]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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35
[SID49671450]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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36
[SID26535148]
 Maybridge screen to identify antagonists of kappa opioid receptor 1 (OPRK1): fluorescence-based cell-based assay [AID652031, Type: screening]opioid receptor, kappa 1 [Homo sapiens] [gi:119607129]
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37
[SID26535148]
 Maybridge screen to identify antagonists of kappa opioid receptor 1 (OPRK1): fluorescence-based cell-based assay [AID652031, Type: screening]opioid receptor, kappa 1 [Homo sapiens] [gi:119607129]
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38
[SID26535148]
 Maybridge screen to identify antagonists of kappa opioid receptor 1 (OPRK1): fluorescence-based cell-based assay [AID652031, Type: screening]opioid receptor, kappa 1 [Homo sapiens] [gi:119607129]
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39
[SID26535148]
 Maybridge screen to identify antagonists of kappa opioid receptor 1 (OPRK1): fluorescence-based cell-based assay [AID652031, Type: screening]opioid receptor, kappa 1 [Homo sapiens] [gi:119607129]
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40
[SID49671450]
EC50 uHTS identification of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1777, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
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41
[SID49671450]
EC50 uHTS identification of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1777, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
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42
[SID49671450]
EC50 uHTS identification of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1777, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
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43
[SID49671450]
EC50 uHTS identification of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1777, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
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44
[SID49671450]
IC50 uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
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45
[SID49671450]
IC50 uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
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46
[SID49671450]
IC50 uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
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47
[SID49671450]
IC50 uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
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48
[SID49671450]
 Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). [AID2435, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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49
[SID49671450]
 Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). [AID2435, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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50
[SID49671450]
 Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). [AID2435, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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