BAS 00693323 (CID 54687089) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(27)
 
 
Inactive(438)
 
 
Inconclusive(19)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
7TM GPCR Srsx(8)
 
 
 
LRR RI(6)
 
 
 
TRP 2(5)
 
 
BRLZ(5)
 
 
 
 
BioAssay Types:
Screening(331)
 
 
 
Confirmatory(144)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(104)
 
 
 
 
 
IC50(29)
 
 
 
 
EC50(9)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 485    Data Row: 485   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49730053]
IC50 1.56Dose Response confirmation of inhibitors of NALP3 in yeast using a Caspase-1-ASC counter screen [AID488800, Type: confirmatory]NLRP3 protein [Homo sapiens] [gi:219518789]
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2
[SID49730053]
IC50 1.94Dose Response confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay [AID488799, Type: confirmatory]NLRP3 protein [Homo sapiens] [gi:219518789]
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3
[SID49730053]
Potency 2.3109qHTS of Nrf2 Activators: Hit Validation in Primary Assay [AID651593, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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4
[SID49730053]
Potency 2.3109qHTS of Nrf2 Activators: Hit Validation in Primary Assay [AID651593, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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5
[SID49730053]
Potency 2.3109qHTS of Nrf2 Activators: Hit Validation in Primary Assay [AID651593, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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6
[SID49730053]
Potency 2.3109qHTS of Nrf2 Activators: Hit Validation in Primary Assay [AID651593, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
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7
[SID49730053]
EC50 4.245Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
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8
[SID49730053]
EC50 4.646Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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9
[SID49730053]
EC50 5.36Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex [AID602473, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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10
[SID49730053]
EC50 5.36Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex [AID602473, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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11
[SID49730053]
Potency 17.7828qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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12
[SID49730053]
EC50 18.59Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
View
13
[SID49730053]
 A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
View
14
[SID49730053]
 HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening]
View
15
[SID49730053]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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16
[SID49730053]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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17
[SID49730053]
 Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
View
18
[SID49730053]
 uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
View
19
[SID49730053]
 uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
View
20
[SID49730053]
 Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify nonselective agonists [AID651787, Type: screening]GNA15 gene product [Homo sapiens] [gi:156104883]
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21
[SID49730053]
 Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify nonselective Ga16 antagonists [AID651952, Type: screening]GNA15 gene product [Homo sapiens] [gi:156104883]
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22
[SID49730053]
 Fluorescence-based biochemical primary high throughput confirmation assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID652036, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
View
23
[SID49730053]
 Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]PPP1CA gene product [Homo sapiens] [gi:56790945]
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24
[SID49730053]
 Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). [AID2435, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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25
[SID49730053]
 Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). [AID2435, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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26
[SID49730053]
 Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). [AID2435, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
View
27
[SID49730053]
 Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID651800, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
View
28
[SID49730053]
 Single concentration confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay - retest [AID488794, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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29
[SID49730053]
 Single concentration confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay [AID435006, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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30
[SID49730053]
 uHTS Luminescent assay for identification of inhibitors of NALP3 in yeast [AID2825, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
View
31
[SID49730053]
 Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
View
32
[SID49730053]
 Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
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33
[SID49730053]
 MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
View
34
[SID49730053]
 Fluorescence-based cell-based primary high throughput confirmation assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID651783, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
View
35
[SID49730053]
 Fluorescence-based cell-based primary high throughput confirmation assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID651783, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
View
36
[SID49730053]
 Counter-screen against parental HEK293 cells for identification of compounds that activate MrgX1 receptor signaling [AID624115, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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37
[SID49730053]
 Counter-screen against parental HEK293 cells for identification of compounds that activate MrgX1 receptor signaling [AID624115, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View
38
[SID49730053]
 Re-confirmation screening for identification of compounds that activate MrgX1 receptor signaling [AID602412, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View
39
[SID49730053]
 Re-confirmation screening for identification of compounds that activate MrgX1 receptor signaling [AID602412, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View
40
[SID49730053]
 Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View
41
[SID49730053]
 Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View
42
[SID49730053]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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43
[SID49730053]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
44
[SID49730053]
Potency 0.3162qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
View
45
[SID49730053]
Potency 2.2387qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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46
[SID49730053]
Potency 50.1187qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]PIN1 gene product [Homo sapiens] [gi:5453898]
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47
[SID49730053]
Potency 50.1187qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]PIN1 gene product [Homo sapiens] [gi:5453898]
View
48
[SID49730053]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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49
[SID49730053]
IC50 94.106Fluorescence-based biochemical primary high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID686957, Type: confirmatory]TCRAV4S1 [Homo sapiens] [gi:2358024]
View
50
[SID49730053]
IC50 94.106Counterscreen for inhibitors of T-cell receptor (TCR)-CD3 interaction: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe [AID686958, Type: confirmatory]ALB gene product [Bos taurus] [gi:30794280]
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