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N'-decanoyl-1-ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide (CID 54687080) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(686)
 
 
Inconclusive(10)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(41)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Screening(478)
 
 
 
 
Confirmatory(198)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(142)
 
 
 
 
 
IC50(39)
 
 
EC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 640    Data Row: 706   Total Pages: 36   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24803146]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID24803146]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen [AID1456, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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3
[SID24803146]
Fluorescence Cell-Based Primary HTS of C.albicans growth in the presence of Fluconazole and compound [AID1979, Type: screening]heat shock protein 90 [Candida albicans] [gi:994798]
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4
[SID24803146]
uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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5
[SID24803146]
Screen for Chemicals that Inhibit the RAM Network [AID868, Type: screening]
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6
[SID24803146]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Counterscreen with HEK cells [AID1716, Type: other]
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7
[SID24803146]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Retesting of KCC2 cells with Ouabain [AID1717, Type: other]
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8
[SID24803146]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Counterscreen 2 with HEK cells [AID1718, Type: other]
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9
[SID24803146]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay 3 with KCC2 cells [AID1714, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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10
[SID24803146]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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11
[SID24803146]
Potency 0.0562qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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12
[SID24803146]
Potency 3.5481qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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13
[SID24803146]
Potency 3.6964Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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14
[SID24803146]
Potency 15.8489qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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15
[SID24803146]
EC50 38Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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16
[SID24803146]
Potency 63.0957qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen [AID720708, Type: confirmatory]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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17
[SID24803146]
Potency 100HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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18
[SID24803146]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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19
[SID24803146]
EC50 160Fluorescence Cell-Based Secondary Assay for toxicity in mammalian fibroblasts [AID2327, Type: confirmatory]
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20
[SID24803146]
uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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