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SMR000011453 (CID 54686771) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(813)
 
 
Inconclusive(17)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(569)
 
 
 
 
 
Confirmatory(247)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(165)
 
 
 
 
 
IC50(49)
 
 
EC50(12)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 771    Data Row: 840   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID852125]
Potency 12.5893qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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2
[SID852125]
Potency 12.5893qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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3
[SID852125]
Screen for Chemicals that Extend Yeast Lifespan [AID775, Type: screening]
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4
[SID852125]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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5
[SID852125]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin I, cardiac muscle [Homo sapiens] [gi:151101270]
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6
[SID852125]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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7
[SID852125]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin C, slow skeletal and cardiac muscles [Homo sapiens] [gi:4507615]
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8
[SID852125]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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9
[SID852125]
Potency Activators of T cell receptors: qHTS campaign [AID504894, Type: confirmatory]T cell receptor [Homo sapiens] [gi:553160]
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10
[SID852125]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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11
[SID852125]
Potency 1.3115Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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12
[SID852125]
Potency 8.9125qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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13
[SID852125]
Potency 15.003qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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14
[SID852125]
Potency 39.8107HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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15
[SID852125]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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16
[SID852125]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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17
[SID852125]
qHTS Assay for Spectroscopic Profiling in Rhodamine Spectral Region [AID594, Type: confirmatory]
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18
[SID852125]
qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction [AID595, Type: confirmatory]
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19
[SID852125]
qHTS Assay for Epigenetic Modulators [AID597, Type: confirmatory]
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20
[SID852125]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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21
[SID852125]
Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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22
[SID852125]
qHTS Assay for Spectroscopic Profiling in Texas Red Spectral Region [AID587, Type: other]
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23
[SID852125]
qHTS Assay for Spectroscopic Profiling in Resorufin Spectral Region [AID588, Type: other]
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24
[SID852125]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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25
[SID852125]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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26
[SID852125]
qHTS Assay for Spectroscopic Profiling in A488 Spectral Region [AID591, Type: other]
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27
[SID852125]
Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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28
[SID852125]
Cell signaling CRE-BLA (Fsk stim) [AID662, Type: confirmatory]
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29
[SID852125]
Profiling the NIH Molecular Libraries Small Molecule Repository: Absorbance at 340 nm [AID708, Type: screening]
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30
[SID852125]
Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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31
[SID852125]
Antimicrobial HTS Assay for E. coli BW25113 (wild type) - Expanded Screen [AID710, Type: screening]
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32
[SID852125]
Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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33
[SID852125]
Identification of Molecular Probes that Reverse MRP-Mediated Drug Resistance [AID602, Type: screening]
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34
[SID852125]
qHTS Assay for Inhibitors of DNA Polymerase III Holoenzyme System [AID603, Type: confirmatory]
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35
[SID852125]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HT1080 cells) [AID620, Type: confirmatory]
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36
[SID852125]
Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [AID626, Type: screening]
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37
[SID852125]
Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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38
[SID852125]
Isolation of Inhibitors of Her-Kinase Expression - 66K library screen [AID645, Type: screening]
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39
[SID852125]
qHTS Assay for Spectroscopic Profiling in A647 Spectral Region [AID592, Type: other]
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40
[SID852125]
Potency qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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41
[SID852125]
High-content cell-based screening for modulators of autophagy [AID463193, Type: screening]microtubule-associated proteins 1A/1B light chain 3A isoform b [Homo sapiens] [gi:31563518]
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42
[SID852125]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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43
[SID852125]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL. [AID1007, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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44
[SID852125]
Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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45
[SID852125]
Epi-absorbance primary biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase [AID1556, Type: screening]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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46
[SID852125]
Potency qHTS Assay for Modulators of Lamin A Splicing [AID1487, Type: confirmatory]lamin isoform A-delta10 [Homo sapiens] [gi:27436948]
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47
[SID852125]
IC50 uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. [AID1434, Type: confirmatory]runt-related transcription factor 1 isoform AML1c [Homo sapiens] [gi:19923198]
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48
[SID852125]
uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb via a fluorescence resonance energy transfer (FRET) assay. [AID1496, Type: screening]runt-related transcription factor 1 isoform AML1c [Homo sapiens] [gi:19923198]
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49
[SID852125]
Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID522, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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50
[SID852125]
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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