NSC119911 (CID 54686376) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(74)
 
 
Unspecified(8)
 
 
Top Targets:
Gp dh C(1)
 
 
HSPA1-2 6-8-l..(1)
 
 
MH2 SMAD 2 3(1)
 
 
RNase HI euka..(1)
 
 
RNase HI prok..(1)
 
 
BioAssay Types:
Confirmatory(64)
 
 
 
 
Literature(14)
 
 
 
 
Screening(6)
 
 
 
BioActivity Types:
IC50(12)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 91    Data Row: 92   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26514297]
IC50 0.332In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study [AID1072, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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2
[SID26514297]
IC50 2.73In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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3
[SID26514297]
IC50 2.73In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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4
[SID26514297]
IC50 2.73In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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5
[SID103566040]
IC50 11Inhibition of beta-lactamase AmpC [AID318865, Type: Literature]
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6
[SID26514297]
IC50 15.8GAPDH Dose Response Colorimetric Assay [AID1227, Type: confirmatory]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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7
[SID26514297]
IC50 15.8GAPDH Dose Response Colorimetric Assay [AID1227, Type: confirmatory]glyceraldehyde-3-phosphate dehydrogenase [Homo sapiens] [gi:7669492]
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8
[SID103566040]
IC50 20Inhibition of malate dehydrogenase [AID318869, Type: Literature]
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9
[SID103566040]
IC50 24Inhibition of chymotrypsin [AID318867, Type: Literature]
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10
[SID103650864]
IC50 47Inhibition of Escherichia coli MurD assessed as blockade of addition of D-[14C]Glu to UDP-MurNAc-L-Ala [AID393934, Type: Literature]
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11
[SID8139587]
 HIV-2 RNase H Inhibition [AID367, Type: screening]Chain A, Crystal Structure Of Hiv-2 Reverse Transcriptase [gi:24987805]
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12
[SID8139587]
 E. coli RNase H Inhibition [AID365, Type: screening]Ribonuclease HI [gi:67472286]
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13
[SID8139587]
 human RNase H Inhibition [AID366, Type: screening]ribonuclease H1 [Homo sapiens] [gi:21359816]
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14
[SID8139587]
 human RNase H Inhibition [AID366, Type: screening]ribonuclease H1 [Homo sapiens] [gi:21359816]
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15
[SID103566040]
IC50 77Inhibition of malate dehydrogenase in presence of 0.1% Triton X-100 [AID318870, Type: Literature]
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16
[SID103566040]
IC50 95Inhibition of cruzain [AID318871, Type: Literature]
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17
[SID103566040]
IC50 106Inhibition of cruzain in presence of 0.01% Triton X-100 [AID318872, Type: Literature]
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18
[SID103566040]
IC50 600Inhibition of chymotrypsin in presence of 0.1% Triton X-100 [AID318868, Type: Literature]
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19
[SID103566040]
IC50 600Inhibition of beta-lactamase AmpC in presence of 0.1% Triton X-100 [AID318866, Type: Literature]
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20
[SID414516]
 NCI AIDS Antiviral Assay [AID179, Type: confirmatory]
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21
[SID435970]
 NCI AIDS Antiviral Assay [AID179, Type: confirmatory]
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22
[SID103650864]
 Inhibition of Escherichia coli MurD assessed as residual activity at 250 uM by malachite green assay [AID393764, Type: Literature]
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23
[SID103650864]
 Antibacterial activity against Escherichia coli 1411 after 18 hrs by broth microdilution method [AID393936, Type: Literature]
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24
[SID103650864]
 Antibacterial activity against AcrAB deficient Escherichia coli SM1411 after 18 hrs by broth microdilution method [AID393937, Type: Literature]
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25
[SID103650864]
 Antibacterial activity against Staphylococcus aureus 8325-4 after 18 hrs by broth microdilution method [AID393938, Type: Literature]
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26
[SID435970]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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27
[SID414516]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID330, Type: other]
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28
[SID103650864]
 Inhibition of Mycobacterium tuberculosis RmlD assessed as inhibition of dTDP-beta-6-deoxy-L-lyxo-4-hexulose to dTDP-beta-L-rhamnose conversion at 10 ug/ml [AID641626, Type: Literature]dTDP-4-dehydrorhamnose reductase [gi:81671924]
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29
[SID26652760]
 HTS of Smad transcription factor inhibitors [AID630, Type: screening]mothers against decapentaplegic homolog 3 [Homo sapiens] [gi:5174513]
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30
[SID26652760]
 HTS of Smad transcription factor inhibitors [AID630, Type: screening]mothers against decapentaplegic homolog 3 [Homo sapiens] [gi:5174513]
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31
[SID26652760]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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32
[SID26652760]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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33
[SID26652760]
 Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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34
[SID26652760]
 Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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35
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line [AID7, Type: confirmatory]
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36
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line [AID9, Type: confirmatory]
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37
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line [AID13, Type: confirmatory]
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38
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line [AID5, Type: confirmatory]
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39
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line [AID3, Type: confirmatory]
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40
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line [AID1, Type: confirmatory]
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41
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line [AID15, Type: confirmatory]
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42
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line [AID25, Type: confirmatory]
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43
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line [AID29, Type: confirmatory]
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44
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line [AID31, Type: confirmatory]
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45
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell line [AID33, Type: confirmatory]
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46
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell line [AID35, Type: confirmatory]
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47
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line [AID37, Type: confirmatory]
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48
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line [AID39, Type: confirmatory]
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49
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line [AID41, Type: confirmatory]
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50
[SID414516]
 NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line [AID43, Type: confirmatory]
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