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BioActivity Data for Compound NSC119911 (CID 54686376)

BioActivity Outcomes:
Active(12)
 
 
Inactive(74)
 
 
Unspecified(8)
 
 
Top Targets:
HSPA1-2 6-8-l..(2)
 
 
Gp dh C(1)
 
 
MH2 SMAD 2 3(1)
 
 
RNase HI euka..(1)
 
 
RNase HI prok..(1)
 
 
BioAssay Types:
Confirmatory(65)
 
 
 
 
Literature(15)
 
 
 
 
Screening(6)
 
 
 
BioAssay Categories:
In vitro(3)
 
 
In vivo(2)
 
 
Biochemical(11)
 
 
 
BioActivity Types:
IC50(14)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 92    Data Row: 94   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26514297]
IC50 0.332In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study [AID1072, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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2
[SID26514297]
IC50 2.73In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 2 [Homo sapiens] [gi:24234686]
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3
[SID26514297]
IC50 2.73In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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4
[SID242634197]
IC50 3.8Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis [AID1138158, Type: Literature]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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5
[SID103566040]
IC50 11Inhibition of beta-lactamase AmpC [AID318865, Type: Literature]
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6
[SID26514297]
IC50 15.8GAPDH Dose Response Colorimetric Assay [AID1227, Type: confirmatory]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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7
[SID103566040]
IC50 20Inhibition of malate dehydrogenase [AID318869, Type: Literature]
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8
[SID103566040]
IC50 24Inhibition of chymotrypsin [AID318867, Type: Literature]
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9
[SID103650864]
IC50 47Inhibition of Escherichia coli MurD assessed as blockade of addition of D-[14C]Glu to UDP-MurNAc-L-Ala [AID393934, Type: Literature]
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10
[SID8139587]
human RNase H Inhibition [AID366, Type: screening]ribonuclease H1 isoform 1 precursor [Homo sapiens] [gi:21359816]
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11
[SID8139587]
E. coli RNase H Inhibition [AID365, Type: screening]Ribonuclease HI [gi:67472286]
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12
[SID8139587]
HIV-2 RNase H Inhibition [AID367, Type: screening]Chain A, Crystal Structure Of Hiv-2 Reverse Transcriptase [gi:24987805]
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13
[SID103566040]
IC50 77Inhibition of malate dehydrogenase in presence of 0.1% Triton X-100 [AID318870, Type: Literature]
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14
[SID103566040]
IC50 95Inhibition of cruzain [AID318871, Type: Literature]
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15
[SID103566040]
IC50 106Inhibition of cruzain in presence of 0.01% Triton X-100 [AID318872, Type: Literature]
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16
[SID103566040]
IC50 600Inhibition of beta-lactamase AmpC in presence of 0.1% Triton X-100 [AID318866, Type: Literature]
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17
[SID103566040]
IC50 600Inhibition of chymotrypsin in presence of 0.1% Triton X-100 [AID318868, Type: Literature]
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18
[SID414516]
NCI AIDS Antiviral Assay [AID179, Type: confirmatory]
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19
[SID435970]
NCI AIDS Antiviral Assay [AID179, Type: confirmatory]
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20
[SID103650864]
Inhibition of Escherichia coli MurD assessed as residual activity at 250 uM by malachite green assay [AID393764, Type: Literature]
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