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Tetracycline (CID 54685734) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(32)
 
 
Inactive(477)
 
 
Inconclusive(13)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(13)
 
 
Bcl-2 like(5)
 
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(298)
 
 
 
 
Confirmatory(215)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(117)
 
 
 
 
 
IC50(32)
 
 
 
 
EC50(6)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 481    Data Row: 523   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID50085849]
IC50 0.67A screen for inhibitors of the PhoP regulon in Salmonella Typhimurium using a modified counterscreen. [AID1981, Type: confirmatory]
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2
[SID50085849]
Potency 0.9285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID50085849]
IC50 1.01A Counter Screen to identiry small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID2401, Type: confirmatory]
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4
[SID50085849]
IC50 1.71A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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5
[SID50085849]
IC50 2.078A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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6
[SID50085849]
IC50 3.07A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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7
[SID50085849]
Potency 3.1623qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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8
[SID50085849]
IC50 3.55A small molecule screen for inhibitors of the PhoP regulon in Salmonella Typhimurium [AID1863, Type: confirmatory]
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9
[SID50085849]
Potency 12.5893qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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10
[SID50085849]
Potency 39.8107qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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11
[SID50085849]
EC50 50A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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12
[SID50085849]
Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of bacterial viability [AID488956, Type: screening]
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13
[SID50085849]
Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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14
[SID50085849]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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15
[SID50085849]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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16
[SID50085849]
Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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17
[SID50085849]
Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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18
[SID50085849]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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19
[SID50085849]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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20
[SID50085849]
Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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21
[SID50085849]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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22
[SID50085849]
Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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23
[SID50085849]
MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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24
[SID50085849]
Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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25
[SID50085849]
Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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26
[SID50085849]
Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
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27
[SID50085849]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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28
[SID50085849]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) [AID2014, Type: confirmatory]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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29
[SID50085849]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [AID2012, Type: confirmatory]Eukaryotic translation initiation factor 4H [Homo sapiens] [gi:45219878]
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30
[SID50085849]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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31
[SID50085849]
High Throughput Screen for Tat Transport Inhibitors Measured in Microorganism System Using Plate Reader - 2093-01_Inhibitor_SinglePoint_HTS_Activity [AID488895, Type: screening]TatABCE protein translocation system subunit [Escherichia coli str. K-12 substr. MG1655] [gi:90111653]
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32
[SID50085849]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1800, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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33
[SID50085849]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID50085849]
Potency 0.13A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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35
[SID50085849]
Potency 6.3096qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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36
[SID50085849]
AC50_uM 380Fluorescent Polarization Homogeneous Dose Retest to Confirm Inhibitors of Mex-5 Binding to TCR-2 [AID449745, Type: confirmatory]Zinc finger protein mex-5 [gi:55976631]
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37
[SID50085849]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]kelch-like ECH-associated protein 1 [Homo sapiens] [gi:45269145]
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38
[SID50085849]
IC50 uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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39
[SID50085849]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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40
[SID50085849]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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41
[SID50085849]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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42
[SID50085849]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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43
[SID50085849]
Potency qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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44
[SID50085849]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
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45
[SID50085849]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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46
[SID50085849]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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47
[SID50085849]
Potency qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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48
[SID50085849]
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
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49
[SID50085849]
HTS Assay for Inhibitors of Akt Phophorylation: Primary Screen [AID651550, Type: screening]RAC-alpha serine/threonine-protein kinase [gi:60391226]
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50
[SID50085849]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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