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BioActivity Data for Compound Chlortetracycline (CID 54684459)

BioActivity Outcomes:
Active(46)
 
 
Inactive(635)
 
 
Inconclusive(30)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(44)
 
 
Tryp SPc(11)
 
 
 
alkPPc(10)
 
 
Bcl-2 like(9)
 
 
G-alpha(7)
 
 
 
BioAssay Types:
Screening(459)
 
 
 
 
Confirmatory(217)
 
 
 
 
 
Literature(11)
 
 
BioAssay Categories:
In vitro(2)
 
 
In vivo(1)
 
 
Biochemical(111)
 
 
 
Toxicity(9)
 
 
 
Cell-based(114)
 
 
 
Organism-base..(9)
 
 
 
BioActivity Types:
Potency(150)
 
 
 
 
 
IC50(41)
 
 
 
 
EC50(8)
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 644    Data Row: 712   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID855713]
AC50_uM 1.195High Throughput Screen for Tat Transport Inhibitors Measured in Microorganism System Using Plate Reader - 2093-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504941, Type: confirmatory]TatABCE protein translocation system subunit [Escherichia coli str. K-12 substr. MG1655] [gi:90111653]
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2
[SID855713]
IC50_Mean 5.75Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay [AID588400, Type: confirmatory]phospholipase A2 precursor [Homo sapiens] [gi:4505847]
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3
[SID855713]
IC50_Mean 6.14Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. [AID504756, Type: confirmatory]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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4
[SID855713]
Average IC50 7.02High Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interaction [AID1117319, Type: confirmatory]Vif [Human immunodeficiency virus 1] [gi:9629361]
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5
[SID855713]
Average IC50 7.02High Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interaction [AID1117319, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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6
[SID855713]
Potency 11.2202qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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7
[SID855713]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID855713]
Potency 23.1093Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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9
[SID855713]
Potency 39.8107Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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10
[SID855713]
Potency 44.6684qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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11
[SID855713]
Potency 44.6684qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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12
[SID855713]
AC50_uM 46.988Bacterial Growth Inhibition Counterscreen using BacTiter-Glo Measured in Microorganism System Using Plate Reader - 2093-02_Inhibitor_Dose_CherryPick_Activity [AID504843, Type: confirmatory]
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13
[SID855713]
Potency 50.1187qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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14
[SID855713]
Potency 79.4328qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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15
[SID855713]
Average IC50 100An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G [AID1117361, Type: confirmatory]Tat [Human immunodeficiency virus 1] [gi:9629358]
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16
[SID855713]
High Throughput Screen for Tat Transport Inhibitors Measured in Microorganism System Using Plate Reader - 2093-01_Inhibitor_SinglePoint_HTS_Activity [AID488895, Type: screening]TatABCE protein translocation system subunit [Escherichia coli str. K-12 substr. MG1655] [gi:90111653]
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17
[SID855713]
Single concentration confirmation of inhibitors of ATG4B via a fluorescent assay [AID504757, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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18
[SID855713]
uHTS fluorescent assay for identification of inhibitors of ATG4B [AID504462, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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19
[SID855713]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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20
[SID855713]
Clearance of Mutant Huntingtin Protein - Confirmatory screen [AID486, Type: confirmatory]Huntingtin [gi:296434520]
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