4-Hydroxy-3-pentyl-1H-quinolin-2-one (CID 54684098) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(761)
 
 
Inconclusive(11)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
alkPPc(16)
 
 
Bcl-2 like(11)
 
 
Tryp SPc(10)
 
 
7TM GPCR Srsx(10)
 
 
BioAssay Types:
Screening(527)
 
 
 
 
 
Confirmatory(222)
 
 
 
 
 
Literature(7)
 
 
BioActivity Types:
Potency(146)
 
 
 
 
 
IC50(44)
 
 
EC50(10)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 778    Data Row: 780   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID849990]
Potency 25.1189qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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2
[SID849990]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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3
[SID849990]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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4
[SID849990]
 Fluorescence-based biochemical high throughput confirmation assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID651616, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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5
[SID849990]
 Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library) [AID841, Type: screening]
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6
[SID849990]
 Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluroescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) assay to identify assay artifacts [AID652141, Type: screening]
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7
[SID849990]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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8
[SID849990]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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9
[SID849990]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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10
[SID849990]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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11
[SID849990]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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12
[SID849990]
Potency 35.4813qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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13
[SID849990]
Potency 35.4813qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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14
[SID849990]
Potency qHTS Assay for Agonists of the Relaxin Receptor RXFP1 [AID2676, Type: confirmatory]relaxin receptor 1 isoform 1 [Homo sapiens] [gi:85986601]
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15
[SID849990]
Potency qHTS Assay for Agonists of the Relaxin Receptor RXFP1 [AID2676, Type: confirmatory]relaxin receptor 1 isoform 1 [Homo sapiens] [gi:85986601]
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16
[SID849990]
 Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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17
[SID849990]
 Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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18
[SID849990]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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19
[SID849990]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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20
[SID849990]
 uHTS identification of APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493012, Type: screening]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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21
[SID849990]
Potency qHTS for Inhibitors of Vif-A3G Interactions: qHTS [AID602310, Type: confirmatory]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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22
[SID849990]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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23
[SID849990]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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24
[SID849990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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25
[SID849990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate [AID2107, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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26
[SID849990]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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27
[SID849990]
Potency qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. [AID1467, Type: confirmatory]alpha-galactosidase [Homo sapiens] [gi:757912]
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28
[SID849990]
Potency qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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29
[SID849990]
Potency qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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30
[SID849990]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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31
[SID849990]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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32
[SID849990]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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33
[SID849990]
IC50 High Throughput Screening Assay for Hsp70 Inhibitors [AID583, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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34
[SID849990]
 Fluorescence-based counterscreen assay for HCV NS3 helicase inhibitors: biochemical high-throughput screening assay to identify compounds that cause fluorescent intercalator displacement (FID) [AID1845, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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35
[SID849990]
 Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1800, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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36
[SID849990]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Red Fluorophore) [AID892, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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37
[SID849990]
Potency qHTS Assay for Inhibitors of BRCT-Phosphoprotein Interaction (Green Fluorophore) [AID875, Type: confirmatory]Chain A, Solution Structure Of The Brct-C Domain From Human Brca1 [gi:159162802]
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38
[SID849990]
 uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
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39
[SID849990]
Potency qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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40
[SID849990]
 High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set [AID588497, Type: Literature]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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41
[SID849990]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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42
[SID849990]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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43
[SID849990]
Potency qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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44
[SID849990]
IC50 Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocyste [gi:219689243]
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45
[SID849990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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46
[SID849990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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47
[SID849990]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
View
48
[SID849990]
Potency qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID1466, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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49
[SID849990]
Potency qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID1466, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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50
[SID849990]
Potency qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID1466, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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