Oxytetracycline (CID 54680782) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(20)
 
 
Inactive(217)
 
 
Inconclusive(78)
 
 
Unspecified(19)
 
 
Top Targets:
NR LBD PPAR(10)
 
 
 
NR LBD TR(8)
 
 
NR LBD VDR(5)
 
 
 
 
NR LBD ER(4)
 
 
 
 
P53(4)
 
 
BioAssay Types:
Confirmatory(198)
 
 
 
 
Literature(70)
 
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(162)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 229    Data Row: 334   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389774]
Potency 3.3587qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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2
[SID17389774]
Potency 3.3587qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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3
[SID17389774]
Potency 3.5481qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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4
[SID17389774]
Potency 3.7933Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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5
[SID17389774]
Potency 6.3096qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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6
[SID17389774]
Potency 7.0795qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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7
[SID17389774]
Potency 7.0795qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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8
[SID17389774]
Potency 7.0795qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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9
[SID17389774]
Potency 10qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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10
[SID17389774]
Potency 10qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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11
[SID17389774]
Potency 13.4591Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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12
[SID144204660]
Potency 18.8375qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID144204660]
Potency 18.8375qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID144204660]
Potency 18.8375qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID17389774]
Potency 28.1838qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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16
[SID17389774]
Potency 28.1838qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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17
[SID26757862]
Potency 35.4813qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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18
[SID26757862]
Potency 35.4813qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID26757862]
Potency 35.4813qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID26757862]
Potency 35.4813qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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21
[SID17389774]
Potency 44.6684qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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22
[SID17389774]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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23
[SID17389774]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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24
[SID17389774]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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25
[SID17389774]
Potency 50.1187Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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26
[SID92124028]
 A screen for compounds that inhibit replication of Vibrio cholerae chromosome II [AID504770, Type: other]hypothetical protein VC_A0002 [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657380]
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27
[SID8149465]
 Cellular toxicity caused by inducible expressing of N-terminal huntingtin with expanded ployglutamine repeat (Htt-N63-148Q) in PC12 cells (ROSShtt) [AID1590, Type: other]
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28
[SID8149465]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells (LDH100) [AID1596, Type: other]
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29
[SID8149465]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells (LDH016) [AID1608, Type: other]
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30
[SID8149465]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells (LDH08) [AID1609, Type: other]
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31
[SID8149465]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells [AID1610, Type: other]
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32
[SID8149465]
 Protection from expanded polyglutamine huntingtin toxicity in PC12 cells (LDH20) [AID1606, Type: other]
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33
[SID17389774]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_26, Type: Literature]
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34
[SID17389774]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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35
[SID8149465]
 Screen for compounds that induce the human heat shock transcriptional response (HSEluc) [AID1611, Type: other]
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36
[SID8149465]
 Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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37
[SID8149465]
 Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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38
[SID8149465]
 Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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39
[SID8149465]
 Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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40
[SID8149465]
 Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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41
[SID8149465]
 Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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42
[SID8149465]
 Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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43
[SID8149465]
 Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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44
[SID8149465]
 Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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45
[SID8149465]
 Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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46
[SID124973645]
 Antimicrobial activity against Micrococcus luteus after 24 to 48 hrs by serial dilution technique [AID667673, Type: Literature]
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47
[SID124973645]
 Antimicrobial activity against Chromobacterium violaceum after 24 to 48 hrs by serial dilution technique [AID667677, Type: Literature]
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48
[SID124973645]
 Antimicrobial activity against methicillin-resistant Staphylococcus aureus after 24 to 48 hrs by serial dilution technique [AID667674, Type: Literature]
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49
[SID124973645]
 Antimicrobial activity against Escherichia coli after 24 to 48 hrs by serial dilution technique [AID667675, Type: Literature]
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50
[SID124973645]
 Antimicrobial activity against Nocardia flava after 24 to 48 hrs by serial dilution technique [AID667676, Type: Literature]
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