Demeclocycline (CID 54680690) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(46)
 
 
Inconclusive(13)
 
 
Unspecified(22)
 
 
Top Targets:
7TM GPCR Srx(4)
 
 
 
PIKKc TOR(4)
 
 
Pyr redox dim(4)
 
 
 
BRLZ(2)
 
 
PIN FEN1(2)
 
 
 
BioAssay Types:
Confirmatory(54)
 
 
 
 
Literature(34)
 
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(54)
 
 
 
 
IC50(6)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 88    Data Row: 90   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103590232]
IC50 1.88Antimycobacterial activity against Mycobacterium smegmatis grown in Luria-Bertani broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562240, Type: Literature]
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2
[SID103590232]
IC50 1.88Antimycobacterial activity against Mycobacterium smegmatis grown in Luria-Bertani broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562243, Type: Literature]
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3
[SID103590232]
IC50 4.4Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562245, Type: Literature]
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4
[SID103590232]
IC50 4.4Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562242, Type: Literature]
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5
[SID103590232]
IC50 5.92Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limited broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562244, Type: Literature]
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6
[SID103590232]
IC50 5.92Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limited broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562241, Type: Literature]
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7
[SID90341625]
Potency 29.9349qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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8
[SID48415853]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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9
[SID49698631]
 High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1332, Type: confirmatory]
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10
[SID103590232]
 Permeability at pH 6.5 by PAMPA method [AID445445, Type: Literature]
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11
[SID103590232]
 Oral bioavailability in human [AID445446, Type: Literature]
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12
[SID103590232]
 Volume of distribution at steady state in human after iv administration [AID540209, Type: Literature]
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13
[SID103590232]
 Clearance in human after iv administration [AID540210, Type: Literature]
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14
[SID103590232]
 Fraction unbound in human after iv administration [AID540211, Type: Literature]
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15
[SID103590232]
 Mean residence time in human after iv administration [AID540212, Type: Literature]
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16
[SID103590232]
 Half life in human after iv administration [AID540213, Type: Literature]
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17
[SID103590232]
 Literature-mined public compounds from Lowe et al phospholipidosis modelling dataset [AID588208, Type: Literature]
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18
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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19
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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20
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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21
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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22
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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23
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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24
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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25
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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26
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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27
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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28
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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29
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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30
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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31
[SID103590232]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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32
[SID90341625]
Potency 50.1187qHTS of Trypanosoma Brucei Inhibitors: LOPAC Validation [AID624147, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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33
[SID90341625]
Potency Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation [AID504836, Type: Literature]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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34
[SID90341625]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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35
[SID90341625]
Potency qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2 [AID488837, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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36
[SID90341625]
Potency Cytometry Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF cells [AID2668, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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37
[SID90341625]
Potency Cytometry Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF cells [AID2668, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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38
[SID90341625]
Potency High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells [AID2667, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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39
[SID90341625]
Potency High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells [AID2667, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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40
[SID90341625]
Potency High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells [AID2666, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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41
[SID90341625]
Potency High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells [AID2666, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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42
[SID90341625]
Potency Cytometric Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells [AID2660, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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43
[SID90341625]
Potency Cytometric Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells [AID2660, Type: confirmatory]MTOR gene product [Homo sapiens] [gi:4826730]
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44
[SID90341625]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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45
[SID90341625]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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46
[SID90341625]
Potency qHTS of GLP-1 Receptor Agonists: LOPAC Validation [AID624148, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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47
[SID90341625]
Potency qHTS of GLP-1 Receptor Agonists: LOPAC Validation [AID624148, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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48
[SID90341625]
Potency qHTS validation assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID485366, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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49
[SID90341625]
Potency qHTS validation assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID485366, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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50
[SID90341625]
Potency qHTS validation assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID485366, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
View