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Demeclocycline (CID 54680690) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(57)
 
 
Inconclusive(14)
 
 
Unspecified(44)
 
 
Top Targets:
7tm 4(5)
 
 
 
PIKKc TOR(4)
 
 
Pyr redox dim(4)
 
 
 
SIS(3)
 
 
 
Hexokinase 2(3)
 
 
 
BioAssay Types:
Confirmatory(69)
 
 
 
 
Literature(56)
 
 
 
 
BioActivity Types:
Potency(68)
 
 
 
 
IC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 118    Data Row: 126   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103590232]
IC50 1.88Antimycobacterial activity against Mycobacterium smegmatis grown in Luria-Bertani broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562240, Type: Literature]
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2
[SID103590232]
IC50 1.88Antimycobacterial activity against Mycobacterium smegmatis grown in Luria-Bertani broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562243, Type: Literature]
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3
[SID103590232]
IC50 4.4Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562245, Type: Literature]
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4
[SID103590232]
IC50 4.4Antimycobacterial activity against Mycobacterium smegmatis grown in nitrogen -limited broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562242, Type: Literature]
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5
[SID103590232]
IC50 5.92Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limited broth medium assessed as growth inhibition in mid-logarithmic phase by GFP-based fluorescence assay [AID562244, Type: Literature]
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6
[SID103590232]
IC50 5.92Antimycobacterial activity against Mycobacterium smegmatis grown in carbon-limited broth medium assessed as growth inhibition in mid-logarithmic phase by spectrophotometry [AID562241, Type: Literature]
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7
[SID90341625]
Potency 12.5893qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: HTRF assay [AID743207, Type: confirmatory]glucokinase isoform 1 [Homo sapiens] [gi:4503951]
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8
[SID90341625]
Potency 12.5893qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: HTRF assay [AID743207, Type: confirmatory]glucokinase regulatory protein [Homo sapiens] [gi:221625433]
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9
[SID90341625]
Potency 29.9349qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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10
[SID48415853]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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11
[SID49698631]
High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1332, Type: confirmatory]
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12
[SID103590232]
Permeability at pH 6.5 by PAMPA method [AID445445, Type: Literature]
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13
[SID103590232]
Oral bioavailability in human [AID445446, Type: Literature]
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14
[SID103590232]
Literature-mined public compounds from Lowe et al phospholipidosis modelling dataset [AID588208, Type: Literature]
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15
[SID103590232]
Volume of distribution at steady state in human after iv administration [AID540209, Type: Literature]
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16
[SID103590232]
Clearance in human after iv administration [AID540210, Type: Literature]
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17
[SID103590232]
Fraction unbound in human after iv administration [AID540211, Type: Literature]
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18
[SID103590232]
Mean residence time in human after iv administration [AID540212, Type: Literature]
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19
[SID103590232]
Half life in human after iv administration [AID540213, Type: Literature]
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20
[SID103590232]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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