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1-hexyl-4-hydroxy-N-(3-methylpyridin-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide (CID 54679655) - Compound BioActivity Data
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BioActivity Outcomes:
Active(35)
 
 
Inactive(500)
 
 
Inconclusive(18)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
7TM GPCR Srsx(17)
 
 
 
TRP 2(5)
 
 
B zip1(5)
 
 
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(377)
 
 
 
 
Confirmatory(171)
 
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(120)
 
 
 
 
 
IC50(28)
 
 
 
AC50(8)
 
 
EC50(8)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 511    Data Row: 554   Total Pages: 12   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49643092]
EC50 0.507Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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2
[SID49643092]
EC50 0.566Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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3
[SID49643092]
Potency 1.636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID49643092]
EC50 1.981Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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5
[SID49643092]
AbsAC35_uM 2.57Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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6
[SID49643092]
AbsAC1000_uM 3.026In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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7
[SID49643092]
AC50_uM 3.78Cell fusion assay for clade C HIV-1ZM109 Env Measured in Cell-Based System Using Plate Reader - 7013-05_Inhibitor_Dose_CherryPick_Activity [AID652058, Type: confirmatory]
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8
[SID49643092]
AC50_uM 4.02HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
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9
[SID49643092]
Potency 4.1095qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID49643092]
AbsAC35_uM 4.29Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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11
[SID49643092]
AC50_uM 5.24HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_Dose_CherryPick_Activity [AID652057, Type: confirmatory]
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12
[SID49643092]
AC50_uM 5.498ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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13
[SID49643092]
AC50_uM 5.77Control Cell Fusion Counterscreen Assay Measured in Cell-Based System Using Plate Reader - 7013-02_Inhibitor_Dose_CherryPick_Activity [AID652040, Type: confirmatory]
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14
[SID49643092]
AC50_uM 7.921Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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15
[SID49643092]
Potency 7.9433VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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16
[SID49643092]
Potency 8.1995Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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17
[SID49643092]
Potency 14.1254qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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18
[SID49643092]
AC50_uM 28.57CEM21 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7013-03_Inhibitor_Dose_CherryPick_Activity [AID652042, Type: confirmatory]
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19
[SID49643092]
AC50_uM 232.7Luminescence Cell-Based Counter Screen to Identify Inhibitors of Cytokine Induced Apoptosis [AID463206, Type: confirmatory]
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20
[SID49643092]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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21
[SID49643092]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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22
[SID49643092]
uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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23
[SID49643092]
In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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24
[SID49643092]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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25
[SID49643092]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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26
[SID49643092]
Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify nonselective agonists [AID651787, Type: screening]guanine nucleotide-binding protein subunit alpha-15 [Homo sapiens] [gi:156104883]
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27
[SID49643092]
Counterscreen for agonists of the human trace amine associated receptor 1 (hTAAR1): Fluorescence-based cell-based high throughput screening assay to identify nonselective Ga16 antagonists [AID651952, Type: screening]guanine nucleotide-binding protein subunit alpha-15 [Homo sapiens] [gi:156104883]
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28
[SID49643092]
MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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29
[SID49643092]
Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
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30
[SID49643092]
Fluorescence-based biochemical high throughput confirmation assay to identify inhibitors of Protein Phosphatase 1 (PP1) [AID2358, Type: screening]serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform 3 [Homo sapiens] [gi:56790945]
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31
[SID49643092]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human trace amine associated receptor 1 (TAAR1) [AID624466, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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32
[SID49643092]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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33
[SID49643092]
Fluorescence-based cell-based primary high throughput confirmation assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID651783, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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34
[SID49643092]
Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). [AID2435, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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35
[SID49643092]
Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based primary cell-based high throughput assay to identify agonists of the vasopressin 1 receptor (V1R) [AID2797, Type: screening]vasopressin V1a receptor [Homo sapiens] [gi:4502331]
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36
[SID49643092]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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37
[SID49643092]
Potency 7.9433qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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38
[SID49643092]
Potency 35.4813qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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39
[SID49643092]
Potency 63.0957qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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40
[SID49643092]
Potency 79.4328HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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41
[SID49643092]
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity [AID686992, Type: screening]E-selectin precursor [Homo sapiens] [gi:187960042]
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42
[SID49643092]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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43
[SID49643092]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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44
[SID49643092]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of A1 Apoptosis. [AID2462, Type: screening]bcl-2-like protein 11 isoform 1 [Homo sapiens] [gi:20336315]
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45
[SID49643092]
Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alpha [AID2650, Type: screening]glycogen synthase kinase-3 alpha [Homo sapiens] [gi:49574532]
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46
[SID49643092]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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47
[SID49643092]
IC50 uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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48
[SID49643092]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1B, catalytic subunit 3 (PAFAH1B3) [AID492972, Type: screening]platelet-activating factor acetylhydrolase IB subunit gamma [Homo sapiens] [gi:225543099]
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49
[SID49643092]
IC50 Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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50
[SID49643092]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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