4,7-Dihydroxycoumarin (CID 54679630) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(577)
 
 
Inconclusive(8)
 
 
Unspecified(15)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
Bcl-2 like(10)
 
 
alkPPc(10)
 
 
7TM GPCR Srsx(8)
 
 
G-alpha(6)
 
 
 
BioAssay Types:
Screening(406)
 
 
 
Confirmatory(166)
 
 
 
 
 
Literature(21)
 
 
 
 
BioActivity Types:
Potency(118)
 
 
 
 
 
IC50(40)
 
 
 
 
EC50(8)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 603    Data Row: 603   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24824104]
Potency 14.1254qHTS of TDP-43 Inhibitors [AID652104, Type: confirmatory]TAR DNA-binding protein 43 [gi:20140568]
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2
[SID103207579]
IC50 38.85Inhibition of alpha-glucosidase using para-nitrophenyl substrate [AID541338, Type: Literature]
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3
[SID24824104]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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4
[SID103207579]
IC50 300Inhibitory activity against 3'-processing of DNA by HIV-1 integrase [AID93533, Type: Literature]Integrase [gi:82312013]
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5
[SID103207579]
IC50 325Inhibitory activity against HIV-1 integrase [AID93680, Type: Literature]Integrase [gi:82312013]
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6
[SID103207579]
IC50 325Integration of DNA by HIV -1 integrase [AID91424, Type: Literature]Integrase [gi:82312013]
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7
[SID103207579]
IC50 400Inhibition of beta-glucosidase using salicin substrate [AID541494, Type: Literature]
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8
[SID103207579]
 Inhibition of Aspergillus oryzae Beta-galactosidase at 400 uM [AID541342, Type: Literature]
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9
[SID103207579]
 Effect on secondary structure of alpha-glucosidase assessed as alpha-helix content at 0.5 uM bt circular dichroism method [AID541349, Type: Literature]
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10
[SID103207579]
 Effect on secondary structure of alpha-glucosidase assessed as alpha-helix content at 0.3 uM at circular dichroism method [AID541350, Type: Literature]
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11
[SID103207579]
 Effect on secondary structure of alpha-glucosidase assessed as beta-sheet content at 0.5 uM at circular dichroism method [AID541351, Type: Literature]
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12
[SID103207579]
 Effect on secondary structure of alpha-glucosidase assessed as beta-sheet content at 0.3 uM at circular dichroism method [AID541352, Type: Literature]
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13
[SID103207579]
 Effect on secondary structure of alpha-glucosidase assessed as beta-turn content at 0.5 uM at circular dichroism method [AID541353, Type: Literature]
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14
[SID103207579]
 Effect on secondary structure of alpha-glucosidase assessed as beta-turn content at 0.3 uM at circular dichroism method [AID541354, Type: Literature]
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15
[SID103207579]
 Effect on secondary structure of alpha-glucosidase assessed as random content at 0.5 uM at circular dichroism method [AID541355, Type: Literature]
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16
[SID103207579]
 Effect on secondary structure of alpha-glucosidase assessed as random content at 0.3 uM at circular dichroism method [AID541356, Type: Literature]
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17
[SID103207579]
 Inhibition of beta-glucosidase at 400 uM using salicin substrate [AID541263, Type: Literature]
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18
[SID24824104]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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19
[SID24824104]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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20
[SID24824104]
Potency 0.8913qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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21
[SID24824104]
Potency 0.9285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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22
[SID24824104]
Potency 4.1095qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]snurportin-1 [Homo sapiens] [gi:5031833]
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23
[SID24824104]
Potency 39.8107qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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24
[SID24824104]
Potency 39.8107qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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25
[SID24824104]
Potency qHTS Assay for Agonists of the Relaxin Receptor RXFP1 [AID2676, Type: confirmatory]relaxin receptor 1 isoform 1 [Homo sapiens] [gi:85986601]
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26
[SID24824104]
Potency qHTS Assay for Agonists of the Relaxin Receptor RXFP1 [AID2676, Type: confirmatory]relaxin receptor 1 isoform 1 [Homo sapiens] [gi:85986601]
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27
[SID24824104]
 Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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28
[SID24824104]
 Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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29
[SID24824104]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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30
[SID24824104]
 Primary cell-based screen for identification of compounds that allosterically activate the Choline Transporter (CHT) [AID488977, Type: screening]SLC5A7 gene product [Homo sapiens] [gi:11141885]
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31
[SID24824104]
 uHTS identification of APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493012, Type: screening]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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32
[SID24824104]
Potency qHTS for Inhibitors of Vif-A3G Interactions: qHTS [AID602310, Type: confirmatory]APOBEC3G gene product [Homo sapiens] [gi:13399304]
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33
[SID24824104]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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34
[SID24824104]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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35
[SID24824104]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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36
[SID24824104]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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37
[SID24824104]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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38
[SID24824104]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2661, Type: screening]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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39
[SID24824104]
 uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphatase [AID2805, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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40
[SID24824104]
 uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase [AID2806, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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41
[SID24824104]
Potency qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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42
[SID24824104]
Potency qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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43
[SID24824104]
 uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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44
[SID24824104]
 uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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45
[SID24824104]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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46
[SID24824104]
Potency qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium [AID1457, Type: confirmatory]Inositol monophosphatase [gi:44888968]
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47
[SID24824104]
IC50 Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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48
[SID24824104]
 High-content cell-based screening for modulators of autophagy [AID463193, Type: screening]microtubule-associated proteins 1A/1B light chain 3A isoform b [Homo sapiens] [gi:31563518]
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49
[SID24824104]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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50
[SID24824104]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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