3-[(2E)-3-(4-Chlorophenyl)prop-2-enoyl]-4-hydroxy-6-methyl-2H-pyran-2-one (CID 54679621) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(24)
 
 
Inactive(416)
 
 
Inconclusive(22)
 
 
Unspecified(9)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
Death TRAILR..(12)
 
 
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
KCNQ channel(4)
 
 
BioAssay Types:
Screening(327)
 
 
 
 
Confirmatory(134)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(99)
 
 
 
 
 
IC50(23)
 
 
 
 
EC50(9)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 461    Data Row: 471   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49664936]
Potency 2.1331qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID49664936]
EC50 6.385Dose Response of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae specifically LAP4 based on MLPCN hits [AID2745, Type: confirmatory]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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3
[SID49664936]
CC50 17.62Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
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4
[SID49664936]
IC50 25A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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5
[SID49664936]
Potency 25.1189qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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6
[SID49664936]
Potency 25.1189qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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7
[SID49664936]
 uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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8
[SID49664936]
 Single concentration confirmation of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463218, Type: screening]TPA: Tim23p [Saccharomyces cerevisiae S288c] [gi:285814664]
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9
[SID49664936]
 Single concentration confirmation of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463213, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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10
[SID49664936]
 uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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11
[SID49664936]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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12
[SID49664936]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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13
[SID49664936]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID1962, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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14
[SID49664936]
 Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]PPP1CA gene product [Homo sapiens] [gi:56790945]
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15
[SID49664936]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite H. contortus (hcDAF-12) [AID652067, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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16
[SID49664936]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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17
[SID49664936]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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18
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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19
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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20
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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21
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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22
[SID49664936]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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23
[SID49664936]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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24
[SID49664936]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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25
[SID49664936]
 Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae, specifically LAP4 Cherry Pick Compounds [AID2271, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
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26
[SID49664936]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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27
[SID49664936]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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28
[SID49664936]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]
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29
[SID49664936]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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30
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_7, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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31
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_7, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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32
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_8, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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33
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_8, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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34
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_9, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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35
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_9, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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36
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_10, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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37
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_10, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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38
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_2, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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39
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_2, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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40
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_3, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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41
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_3, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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42
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_4, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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43
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_4, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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44
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_5, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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45
[SID49664936]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_5, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
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46
[SID49664936]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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47
[SID49664936]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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48
[SID49664936]
Potency 0.5623qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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49
[SID49664936]
Potency 10qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ATXN2 gene product [Homo sapiens] [gi:171543895]
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50
[SID49664936]
Potency 18.4927qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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