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CHEMBL334378 (CID 54679302) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(205)
 
 
Inconclusive(29)
 
 
Unspecified(6)
 
 
Top Targets:
p450(9)
 
 
 
 
7TM GPCR Srx(7)
 
 
 
Pyr redox dim(5)
 
 
PLN02808(5)
 
 
ANK(4)
 
 
BioAssay Types:
Confirmatory(207)
 
 
 
 
 
Screening(13)
 
 
Literature(10)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(185)
 
 
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 219    Data Row: 246   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103365604]
IC50 0.0121Affinity for the glycine binding site on rat N-methyl-D-aspartate glutamate receptor 1, determined by displacement of the glycine site antagonist [3H]L-689,560 from rat cortical membranes [AID143473, Type: Literature]
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2
[SID50106476]
Potency 10qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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3
[SID11111365]
Potency 12.5893qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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4
[SID11111365]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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5
[SID103857009]
Wombat Data for BeliefDocking [AID493017, Type: Literature] [geneid:2902]
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6
[SID11111365]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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7
[SID11111365]
Potency 39.8107qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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8
[SID103365604]
Human serum albumin index was measured by retention time on an HPLC column containing human albumin [AID203505, Type: Literature]
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9
[SID103365604]
Partition coefficient (logP) [AID19623, Type: Literature]
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10
[SID103365604]
Anticonvulsant activity measured by its ability to protect against audiogenic seizure in DBA/2 mice when dosed intraperitoneally 30 min prior to seizure induction. [AID113804, Type: Literature]
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11
[SID11111365]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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12
[SID50106476]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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13
[SID90341362]
Potency 0.0067Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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14
[SID50106476]
Potency 0.0224qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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15
[SID90341362]
Potency 1qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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16
[SID90341362]
Potency 1.122qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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17
[SID90341362]
Potency 5.6234qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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18
[SID11111365]
Potency 10qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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19
[SID85231105]
Potency 37.6858qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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20
[SID50106476]
Potency 44.6684qHTS Validation Assay for Identification of Novel General Anesthetics [AID2323, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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