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4-hydroxy-2-oxo-1-pentyl-N-(pyridin-4-yl)-1,2-dihydroquinoline-3-carboxamide (CID 54678825) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(248)
 
 
Inconclusive(10)
 
 
Top Targets:
alkPPc(12)
 
 
7TM GPCR Srx(10)
 
 
7TM GPCR Srsx(6)
 
 
NR LBD ROR li..(4)
 
 
PMI typeI(4)
 
 
BioAssay Types:
Confirmatory(154)
 
 
 
 
Screening(112)
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(93)
 
 
 
IC50(34)
 
 
EC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 253    Data Row: 269   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7973266]
HIV-1 RT-RNase H MLSCN HTS MH077605 [AID565, Type: screening]Chain A, High Resolution Structures Of Hiv-1 Rt From Four Rt- Inhibitor Complexes [gi:1431733]
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2
[SID7973266]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD1 [AID1578, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 1 [Homo sapiens] [gi:5174617]
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3
[SID7973266]
HTS for BAP1 Enzyme inhibitors [AID436, Type: screening]Ubiquitin carboxyl-terminal hydrolase BAP1 [gi:68565074]
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4
[SID7973266]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
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5
[SID7973266]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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6
[SID7973266]
High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Pilot Screen [AID823, Type: screening]
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7
[SID7973266]
High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Pilot Screen [AID824, Type: screening]
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8
[SID7973266]
Yeast Lifespan Shortening Chemical Screening, Permissive Growth Control - Pilot Screen [AID705, Type: screening]
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9
[SID7973266]
Yeast Lifespan Shortening Chemical Screening, Restrictive Growth Control - Pilot Screen [AID706, Type: screening]
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10
[SID7973266]
Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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11
[SID7973266]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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12
[SID7973266]
Potency 0.0657Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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13
[SID7973266]
Potency 2.8184qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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14
[SID7973266]
IC50 uHTS absorbance assay for the identification of compounds that inhibit PHOSPHO1 [AID1565, Type: confirmatory]phosphoethanolamine/phosphocholine phosphatase isoform 1 [Homo sapiens] [gi:219689097]
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15
[SID7973266]
Potency qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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16
[SID7973266]
HTS for LYP Inhibitors-an Autoimmunity Target - Primary screen [AID606, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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17
[SID7973266]
IC50 uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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18
[SID7973266]
Potency qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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19
[SID7973266]
Potency qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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20
[SID7973266]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent) [AID1476, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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21
[SID7973266]
Potency qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent) [AID1478, Type: confirmatory]Chain A, Crystal Structure Of Cruzain Covalently Bound To A Purine Nitrile [gi:281307097]
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22
[SID7973266]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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23
[SID7973266]
Potency qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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24
[SID7973266]
Potency qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1722, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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25
[SID7973266]
HTS for LYP Inhibitors-an Autoimmunity Target - Primary screen [AID606, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 2 [Homo sapiens] [gi:301171662]
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26
[SID7973266]
Potency qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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27
[SID7973266]
Factor XIIa Mixture HTS [AID684, Type: screening]Coagulation factor XII [gi:317373446]
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28
[SID7973266]
Potency qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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29
[SID7973266]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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30
[SID7973266]
Potency qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia [AID485349, Type: confirmatory]serine-protein kinase ATM [Homo sapiens] [gi:71902540]
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31
[SID7973266]
Potency qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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32
[SID7973266]
HTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1 [AID540275, Type: screening]transient receptor potential cation channel subfamily V member 1 [Homo sapiens] [gi:74315350]
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33
[SID7973266]
HTS Assay for Compounds that Act as Potentiators of the Vanilloid Receptor 1 [AID540277, Type: screening]transient receptor potential cation channel subfamily V member 1 [Homo sapiens] [gi:74315350]
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34
[SID7973266]
qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]tRNA threonylcarbamoyladenosine biosynthesis protein TsaE [gi:84028058]
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35
[SID7973266]
Potency qHTS Assay for Agonists of the Relaxin Receptor RXFP1 [AID2676, Type: confirmatory]relaxin receptor 1 isoform 1 [Homo sapiens] [gi:85986601]
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36
[SID7973266]
HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1497, Type: screening]integrin alpha-M isoform 2 precursor [Homo sapiens] [gi:88501734]
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37
[SID7973266]
HTS identification of compounds that enhance the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1499, Type: screening]integrin alpha-M isoform 2 precursor [Homo sapiens] [gi:88501734]
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38
[SID7973266]
HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1497, Type: screening]integrin beta-2 precursor [Homo sapiens] [gi:89191865]
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39
[SID7973266]
HTS identification of compounds that enhance the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1499, Type: screening]integrin beta-2 precursor [Homo sapiens] [gi:89191865]
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40
[SID7973266]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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41
[SID7973266]
HTS for 14-3-3 protein interaction modulators [AID422, Type: screening]14-3-3 protein gamma [Homo sapiens] [gi:21464101]
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42
[SID7973266]
Cathepsin S [AID501, Type: screening]cathepsin S isoform 1 preproprotein [Homo sapiens] [gi:23110962]
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43
[SID7973266]
Potency qHTS assay for re-activators of p53 using a Luc reporter [AID504706, Type: confirmatory]P53 [Homo sapiens] [gi:23491729]
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44
[SID7973266]
IC50 High Throughput Screening Assay for Hsc70 Inhibitors [AID568, Type: confirmatory]heat shock cognate 71 kDa protein isoform 2 [Homo sapiens] [gi:24234686]
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45
[SID7973266]
Potency qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2 [AID488837, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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46
[SID7973266]
IC50 High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 isoform 1 [Homo sapiens] [gi:27894344]
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47
[SID8037936]
HIV-1 RNase H Inhibition [AID372, Type: screening]Chain A, Solution Structure Of The Rnase H Domain Of The Hiv-1 Reverse Transcriptase In The Presence Of Magnesium [gi:28949057]
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48
[SID7973266]
qHTS of Yeast-based Assay for SARS-CoV PLP [AID485353, Type: confirmatory]orf1ab polyprotein (pp1ab) [SARS coronavirus] [gi:30124074]
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49
[SID7973266]
EC50 HCS for Compounds that Up-Regulate Insulin Promoter Activity in MIN6 Cells [AID1625, Type: confirmatory]
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50
[SID7973266]
IC50 HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells [AID1628, Type: confirmatory]
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