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SMR000037641 (CID 54678160) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(800)
 
 
Inconclusive(17)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(554)
 
 
 
 
 
Confirmatory(246)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(166)
 
 
 
 
 
IC50(50)
 
 
 
EC50(11)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 760    Data Row: 824   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID859666]
Potency 5.6234qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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2
[SID859666]
Potency 11.2202qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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3
[SID859666]
Potency 12.5893qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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4
[SID859666]
IC50 Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP) [AID1445, Type: confirmatory]m1-family aminopeptidase [Plasmodium falciparum 3D7] [gi:124512980]
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5
[SID859666]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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6
[SID859666]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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7
[SID859666]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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8
[SID859666]
Potency 5.0119qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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9
[SID859666]
Potency 7.0795qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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10
[SID859666]
Potency 12.5893qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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11
[SID859666]
Potency 79.4328HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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12
[SID859666]
qHTS Assay for Spectroscopic Profiling in A488 Spectral Region [AID591, Type: other]
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13
[SID859666]
HTS for Inhibition of CaV1.3 ICDI/IQ interaction using a live-cell FRET assay Measured in Cell-Based System Using Plate Reader - 7081-01_Inhibitor_SinglePoint_HTS_Activity [AID743397, Type: screening]
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14
[SID859666]
Wnt/Beta-catenin HTS Measured in Cell-Based System Using Plate Reader - 2161-01_Activator_SinglePoint_HTS_Activity [AID743398, Type: screening]
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15
[SID859666]
uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651582, Type: screening]
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16
[SID859666]
HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_SinglePoint_HTS_Activity [AID651654, Type: screening]
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17
[SID859666]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with Validation Set [AID651664, Type: screening]
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18
[SID859666]
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity [AID651687, Type: screening]
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19
[SID859666]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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20
[SID859666]
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_Activity [AID651723, Type: screening]
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21
[SID859666]
Whole cell Yeast HTS to identify compounds modulating the fidelity of the start codon recognition in eukaryotes. Measured in Whole Organism System Using Plate Reader - 2155-01_Other_SinglePoint_HTS_Activity [AID602363, Type: screening]
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22
[SID859666]
uHTS identification of small molecule inhibitors of the mitochondrial permeability transition pore via an absorbance assay [AID602449, Type: screening]
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23
[SID859666]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Activator_SinglePoint_HTS_Activity [AID623901, Type: screening]
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24
[SID859666]
HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening] [geneid:3205]
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25
[SID859666]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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26
[SID859666]
Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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27
[SID859666]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
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28
[SID859666]
Full deck counterscreen for positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602247, Type: screening]
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29
[SID859666]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
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30
[SID859666]
Full deck counterscreen for antagonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective inhibitors and assay artifacts using the parental CHOK1 cell line [AID602250, Type: screening]
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31
[SID859666]
uHTS luminescent assay for identification of compounds that enhance the survival of human induced pluripotent stem cells when cultured as single cells [AID602274, Type: screening]
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32
[SID859666]
Small molecule inhibitors of miR122 Measured in Cell-Based System Using Plate Reader - 2144-01_Inhibitor_SinglePoint_HTS_Activity [AID602342, Type: screening]
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33
[SID859666]
Cholera Quorum: HTS for inducers of light production in the absence ofautoinducers using BH1578 (luxS deficient, cqsA deficient) Measured in Microorganism System Using Plate Reader - 2132-01_Agonist_SinglePoint_HTS_Activity [AID588436, Type: screening]
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34
[SID859666]
uHTS identification of small molecule modulators of myocardial damage [AID588492, Type: screening]
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35
[SID859666]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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36
[SID859666]
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
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37
[SID859666]
IC50 A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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38
[SID859666]
Potency qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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39
[SID859666]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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40
[SID859666]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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41
[SID859666]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening] [geneid:2395]
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42
[SID859666]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint_HTS_Activity [AID588334, Type: screening]
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43
[SID859666]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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44
[SID859666]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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45
[SID859666]
Potency qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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46
[SID859666]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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47
[SID859666]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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48
[SID859666]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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49
[SID859666]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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50
[SID859666]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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