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NSC157307 (CID 54677783) - Compound BioActivity Data
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BioActivity Outcomes:
Active(38)
 
 
Inactive(330)
 
 
Inconclusive(17)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srsx(10)
 
 
p450(9)
 
 
 
7TM GPCR Srx(7)
 
 
ZnMc TACE lik..(6)
 
 
 
7tm 2(5)
 
 
 
BioAssay Types:
Confirmatory(181)
 
 
 
 
Screening(167)
 
 
 
Literature(13)
 
 
 
 
BioActivity Types:
Potency(82)
 
 
 
 
IC50(14)
 
 
 
 
EC50(2)
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 358    Data Row: 387   Total Pages: 20   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99357753]
IC50 0.975Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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2
[SID99357753]
IC50_Mean 2.5Dose response confirmation of uHTS inhibitor hits of the mitochondrial permeability transition pore via a fluorescent based counterscreen assay [AID651564, Type: confirmatory]
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3
[SID4253875]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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4
[SID99357753]
IC50_Mean 3.45Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID602180, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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5
[SID99357753]
IC50_Mean 3.45Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID602180, Type: confirmatory]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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6
[SID174494759]
IC50 3.5Inhibition of human recombinant NQO1 [AID304251, Type: Literature]NAD(P)H dehydrogenase [quinone] 1 [gi:118607]
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7
[SID99357753]
IC50_Mean 3.94Dose response confirmation of uHTS inhibitor hits of the mitochondrial permeability transition pore via an absorbance assay [AID651561, Type: confirmatory]
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8
[SID99357753]
IC50_Mean 5.18Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format [AID651639, Type: confirmatory]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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9
[SID99357753]
IC50_Mean 5.18Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format [AID651639, Type: confirmatory]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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10
[SID99357753]
AC50_uM 6.05VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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11
[SID99357753]
Potency 21.1923qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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12
[SID99357753]
Potency 22.3872qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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13
[SID99357753]
Potency 28.1838Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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14
[SID174494759]
IC50 29Inhibition of human recombinant NQO1 in presence of BSA [AID304252, Type: Literature]NAD(P)H dehydrogenase [quinone] 1 [gi:118607]
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15
[SID99357753]
Potency 37.6858qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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16
[SID99357753]
Potency 44.6684qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen [AID720708, Type: confirmatory]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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17
[SID26652221]
Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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18
[SID99357753]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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19
[SID4253875]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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20
[SID99357753]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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