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AC1LXKO1 (CID 54677714) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(527)
 
 
Inconclusive(6)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
TRP 2(5)
 
 
SLC5sbd CHT(5)
 
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(372)
 
 
 
Confirmatory(157)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(120)
 
 
 
 
IC50(31)
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 497    Data Row: 540   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49824684]
IC50 13.1826Dose responses of compounds that inhibit the Choline Transporter (CHT) - 5 point CRC [AID504840, Type: confirmatory]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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2
[SID49824684]
Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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3
[SID49824684]
Fluorescence-based biochemical primary high throughput assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID651800, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
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4
[SID49824684]
Fluorescence-based biochemical primary high throughput confirmation assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID652036, Type: screening]TCRAV4S1 [Homo sapiens] [gi:2358024]
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5
[SID49824684]
Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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6
[SID49824684]
Confirmatory screen for compounds that inhibit the Choline Transporter (CHT) [AID493221, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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7
[SID49824684]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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8
[SID49824684]
Potency 0.0075qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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9
[SID49824684]
Potency 0.3981qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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10
[SID49824684]
Potency 1qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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11
[SID49824684]
Potency 6.5733Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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12
[SID49824684]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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13
[SID49824684]
IC50 94.086Fluorescence-based biochemical primary high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled TCR probe [AID686957, Type: confirmatory]TCRAV4S1 [Homo sapiens] [gi:2358024]
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14
[SID49824684]
IC50 94.086Counterscreen for inhibitors of T-cell receptor (TCR)-CD3 interaction: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe [AID686958, Type: confirmatory]serum albumin precursor [Bos taurus] [gi:30794280]
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15
[SID49824684]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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16
[SID49824684]
Potency qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen [AID720708, Type: confirmatory]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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17
[SID49824684]
Potency qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen [AID720711, Type: confirmatory]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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18
[SID49824684]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) [AID588352, Type: screening]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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19
[SID49824684]
Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). [AID2435, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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20
[SID49824684]
Fluorescence-based primary cell-based high throughput screening assay to identify potentiators of Oxytocin Receptor (OXTR) [AID2445, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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21
[SID49824684]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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22
[SID49824684]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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23
[SID49824684]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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24
[SID49824684]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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25
[SID49824684]
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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26
[SID49824684]
Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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27
[SID49824684]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate KCNQ1 potassium channels [AID2648, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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28
[SID49824684]
IC50 Image-Based HTS for Selective Antagonists of GPR35 [AID2058, Type: confirmatory]G-protein coupled receptor 35 isoform a [Homo sapiens] [gi:33695097]
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29
[SID49824684]
EC50 Image-based HTS for Selective Agonists of GPR55 [AID1961, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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30
[SID49824684]
IC50 Image-Based HTS for Selective Antagonists for GPR55 [AID2013, Type: confirmatory]G-protein coupled receptor 55 [Homo sapiens] [gi:33695107]
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31
[SID49824684]
Potency A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression [AID624263, Type: confirmatory]PINK1 [Homo sapiens] [gi:37183032]
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32
[SID49824684]
uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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33
[SID49824684]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase 5 (PP5). [AID1987, Type: screening]PPP5C protein, partial [Homo sapiens] [gi:37589898]
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34
[SID49824684]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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35
[SID49824684]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1). [AID588819, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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36
[SID49824684]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
View
37
[SID49824684]
uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COP9 signalosome complex subunit 5 [Homo sapiens] [gi:38027923]
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38
[SID49824684]
MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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39
[SID49824684]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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40
[SID49824684]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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41
[SID49824684]
EC50 uHTS identification of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1777, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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42
[SID49824684]
IC50 uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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43
[SID49824684]
uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
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44
[SID49824684]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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45
[SID49824684]
IC50 uHTS identification of small molecule antagonists of the binding of Siah-1 and a peptide ligand via a fluorescence polarization assay. [AID1817, Type: confirmatory]plectin 1 [Homo sapiens] [gi:40849930]
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46
[SID49824684]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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47
[SID49824684]
uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]fatty acid synthase [Homo sapiens] [gi:41872631]
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48
[SID49824684]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype [AID1529, Type: screening]mitogen-activated protein kinase kinase kinase 3 isoform 1 [Homo sapiens] [gi:42794767]
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49
[SID49824684]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [AID2012, Type: confirmatory]Eukaryotic translation initiation factor 4H [Homo sapiens] [gi:45219878]
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50
[SID49824684]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]kelch-like ECH-associated protein 1 [Homo sapiens] [gi:45269145]
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