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AGN-PC-0AAFPM (CID 54677435) - Compound BioActivity Data
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BioActivity Outcomes:
Active(44)
 
 
Inactive(653)
 
 
Inconclusive(19)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(17)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(472)
 
 
 
 
Confirmatory(219)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(144)
 
 
 
 
 
IC50(45)
 
 
 
 
EC50(12)
 
 
 
 
AC50(9)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 649    Data Row: 717   Total Pages: 36   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24805024]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID24805024]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID24805024]
Absolute IC50 (XBP1) 1.8XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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4
[SID24805024]
IC50 2.4Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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5
[SID24805024]
Potency 2.6169Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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6
[SID24805024]
Absolute IC50 (CHOP) 2.64CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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7
[SID24805024]
EC50 2.978Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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8
[SID24805024]
EC50 2.998Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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9
[SID24805024]
CC50 3.512A Cell Based Secondary Assay to Explore Cytotoxicity in THP-1 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID489025, Type: confirmatory]
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10
[SID24805024]
IC50_Mean 3.55Dose response validation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay [AID651570, Type: confirmatory]protein Wnt-3a precursor [Mus musculus] [gi:7106447]
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11
[SID24805024]
AC50_uM 3.681MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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12
[SID24805024]
AC50_uM 3.681MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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13
[SID24805024]
AC50_uM 3.681MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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14
[SID24805024]
Potency 4.1095Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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15
[SID24805024]
IC50 5.03A Cell Based Secondary Assay to Explore Compounds that Modulate Non-Replicating, Drug-tolerant Compounds in Replicating H37Rv TB of Mycobacterium tuberculosis [AID492952, Type: confirmatory]
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16
[SID24805024]
Potency 5.1735Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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17
[SID24805024]
CC50 7.38A Cell Based Secondary Assay to Explore Cytotoxicity in Vero E6 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID492998, Type: confirmatory]
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18
[SID24805024]
IC50_Mean 9.19Dose response confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602464, Type: confirmatory]Gli1 [Mus musculus] [gi:6009644]
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19
[SID24805024]
CC50 10.197A Cell Based Secondary Assay to Explore Cytotoxicity in HepG2 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID489018, Type: confirmatory]
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20
[SID24805024]
EC50 13.009Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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