LFM A13 (CID 54676905) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(16)
 
 
Inactive(545)
 
 
Inconclusive(35)
 
 
Unspecified(98)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
Pyr redox dim(10)
 
 
HELICc(8)
 
 
 
POLO box 1(7)
 
 
 
7TM GPCR Srsx(7)
 
 
BioAssay Types:
Screening(287)
 
 
 
 
Confirmatory(276)
 
 
 
 
Literature(122)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(262)
 
 
 
 
IC50(44)
 
 
 
 
Ki(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 606    Data Row: 694   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103515372]
IC50 2.5Inhibition of recombinant BTK [AID325651, Type: Literature]
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2
[SID103515372]
IC50 2.5Inhibition of BTK [AID370569, Type: Literature]
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3
[SID103515372]
IC50 2.5Inhibition of human recombinant BTK expressed in baculovirus expression vector system [AID671740, Type: Literature]Tyrosine-protein kinase BTK [gi:547759]
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4
[SID103515372]
IC50 2.5Inhibition of human recombinant BTK expressed in baculovirus expression vector system [AID671740, Type: Literature]Tyrosine-protein kinase BTK [gi:547759]
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5
[SID103515372]
IC50 7.2Inhibition of human PLK3 measured by Dixon plot [AID284676, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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6
[SID103515372]
IC50 7.2Inhibition of human PLK3 measured by Dixon plot [AID284676, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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7
[SID103515372]
IC50 10Inhibition of Plx1 [AID325652, Type: Literature]
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8
[SID103515372]
IC50 10.3Inhibition of xenopus recombinant Plx1 expressed in Sf21 cells by measuring autophosphorylation by 15-mins kinase assay [AID284650, Type: Literature]
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9
[SID103515372]
IC50 17.2Inhibition of human BTK [AID325650, Type: Literature]Tyrosine-protein kinase BTK [gi:547759]
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10
[SID103515372]
IC50 17.2Inhibition of human BTK [AID325650, Type: Literature]Tyrosine-protein kinase BTK [gi:547759]
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11
[SID103515372]
IC50 32.5Inhibition of Xenopus recombinant Plx1 expressed in Sf21 cells by GST-Cdc25 substrate phosphorylation assay [AID284651, Type: Literature]
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12
[SID103515372]
 Effect on cell division blockade in zebrafish two-cell stage embryo assessed as proliferation arrest at 16-cell stage at 500 uM after 30 to 35 mins [AID284677, Type: Literature]
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13
[SID103515372]
 Effect on cell division blockade in zebrafish egg assessed as cell fusion and lysis at 500 uM after 60 mins [AID284678, Type: Literature]
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14
[SID103515372]
 Antiproliferative activity against anaphase PTK1 cells assessed as delay in mitosis completion [AID284679, Type: Literature]
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15
[SID103515372]
 Antiproliferative activity against prometaphase PTK1 cells assessed as complete arrest at 1 mM within 50 mins [AID284680, Type: Literature]
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16
[SID103515372]
 Induction of aberrant monopolar and multipolar spindle formation in human BT20 cells assessed as at 100 uM [AID284681, Type: Literature]
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17
[SID103515372]
 Induction of aberrant monopolar and multipolar spindle formation in human U373 cells at 100 uM [AID284682, Type: Literature]
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18
[SID14720333]
 Compound Screen Assay, Human GEM [AID397, Type: screening]GTP-binding mitogen-induced T-cell protein [Homo sapiens] [gi:4885263]
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19
[SID56463197]
 HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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20
[SID103515372]
IC50 61Inhibition of human PLK3 [AID284658, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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21
[SID103515372]
IC50 61Inhibition of human PLK3 [AID284658, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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22
[SID103515372]
IC50 61Inhibition of human PLK3 in presence of 25 uM ATP [AID284671, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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23
[SID103515372]
IC50 61Inhibition of human PLK3 in presence of 25 uM ATP [AID284671, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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24
[SID103515372]
IC50 61Inhibition of Plk3 [AID325653, Type: Literature]
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25
[SID103515372]
IC50 79Inhibition of human PLK3 in presence of 50 uM ATP [AID284672, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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26
[SID103515372]
IC50 79Inhibition of human PLK3 in presence of 50 uM ATP [AID284672, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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27
[SID103515372]
IC50 120Inhibition of human PLK3 in presence of 75 uM ATP [AID284673, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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28
[SID103515372]
IC50 120Inhibition of human PLK3 in presence of 75 uM ATP [AID284673, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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29
[SID103515372]
IC50 125Inhibition of human PLK3 in presence of 100 uM ATP [AID284674, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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30
[SID103515372]
IC50 125Inhibition of human PLK3 in presence of 100 uM ATP [AID284674, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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31
[SID103515372]
Ki 185Inhibition of Escherichia coli DdlB [AID346006, Type: Literature]
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32
[SID103515372]
Ki 185Inhibition ATP binding site of Escherichia coli D-alanine-D-alanine ligase B after 15 mins by ATP competitive Lineweaver-Burke plot [AID370565, Type: Literature]
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33
[SID103515372]
Ki 185Inhibition of Escherichia coli D-alanine-D-alanine ligase B after 15 mins by Lineweaver-Burke plot [AID370567, Type: Literature]
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34
[SID103515372]
IC50 215Inhibition of Met kinase [AID284667, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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35
[SID103515372]
IC50 215Inhibition of Met kinase [AID284667, Type: Literature]Hepatocyte growth factor receptor [gi:251757497]
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36
[SID103515372]
IC50 240Inhibition of FYN kinase [AID284664, Type: Literature]Tyrosine-protein kinase Fyn [gi:125370]
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37
[SID103515372]
IC50 240Inhibition of FYN kinase [AID284664, Type: Literature]Tyrosine-protein kinase Fyn [gi:125370]
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38
[SID103515372]
IC50 262Inhibition of human PLK3 in presence of 200 uM ATP [AID284675, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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39
[SID103515372]
IC50 262Inhibition of human PLK3 in presence of 200 uM ATP [AID284675, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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40
[SID103515372]
IC50 267Inhibition of BRK [AID284661, Type: Literature]Protein-tyrosine kinase 6 [gi:8928302]
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41
[SID103515372]
IC50 267Inhibition of BRK [AID284661, Type: Literature]Protein-tyrosine kinase 6 [gi:8928302]
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42
[SID103515372]
IC50 281Inhibition of BMX kinase [AID284662, Type: Literature]Cytoplasmic tyrosine-protein kinase BMX [gi:1705489]
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43
[SID103515372]
IC50 281Inhibition of BMX kinase [AID284662, Type: Literature]Cytoplasmic tyrosine-protein kinase BMX [gi:1705489]
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44
[SID103515372]
IC50 500Inhibition of CHK1 [AID284655, Type: Literature]Serine/threonine-protein kinase Chk1 [gi:317373343]
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45
[SID103515372]
IC50 500Inhibition of CHK1 [AID284655, Type: Literature]Serine/threonine-protein kinase Chk1 [gi:317373343]
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46
[SID103515372]
IC50 500Inhibition of ABL kinase [AID284660, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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47
[SID103515372]
IC50 500Inhibition of ABL kinase [AID284660, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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48
[SID103515372]
IC50 500Inhibition of IKK [AID284656, Type: Literature]
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49
[SID103515372]
IC50 500Inhibition of C-Kit kinase [AID284663, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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50
[SID103515372]
IC50 500Inhibition of C-Kit kinase [AID284663, Type: Literature]Mast/stem cell growth factor receptor Kit [gi:125472]
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