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LFM A13 (CID 54676905) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(28)
 
 
Inactive(640)
 
 
Inconclusive(39)
 
 
Unspecified(749)
 
 
Top Targets:
7TM GPCR Srx(24)
 
 
7TM GPCR Srsx(16)
 
 
 
Pyr redox dim(10)
 
 
ANK(9)
 
 
POLO box 1(8)
 
 
 
 
BioAssay Types:
Screening(338)
 
 
 
 
Confirmatory(321)
 
 
 
 
Literature(125)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
IC50(707)
 
 
 
 
Potency(305)
 
 
 
 
Ki(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1312    Data Row: 1456   Total Pages: 30   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103515372]
IC50 2.5Inhibition of human recombinant BTK expressed in baculovirus expression vector system [AID671740, Type: Literature]Tyrosine-protein kinase BTK [gi:547759]
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2
[SID103515372]
IC50 2.5Inhibition of recombinant BTK [AID325651, Type: Literature]
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3
[SID103515372]
IC50 2.5Inhibition of BTK [AID370569, Type: Literature]
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4
[SID103515372]
IC50 7.2Inhibition of human PLK3 measured by Dixon plot [AID284676, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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5
[SID103515372]
IC50 10Inhibition of Plx1 [AID325652, Type: Literature]
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6
[SID103515372]
IC50 10.3Inhibition of xenopus recombinant Plx1 expressed in Sf21 cells by measuring autophosphorylation by 15-mins kinase assay [AID284650, Type: Literature]
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7
[SID103515372]
IC50 17.2Inhibition of human BTK [AID325650, Type: Literature]Tyrosine-protein kinase BTK [gi:547759]
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8
[SID103515372]
IC50 17.4534SANGER: Inhibition of human NB6 cell growth in a cell viability assay. [AID742394, Type: other]
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9
[SID103515372]
IC50 17.9747SANGER: Inhibition of human CAKI-1 cell growth in a cell viability assay. [AID741998, Type: other]
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10
[SID103515372]
IC50 19.8731SANGER: Inhibition of human SNU-449 cell growth in a cell viability assay. [AID741890, Type: other]
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11
[SID103515372]
IC50 20.8679SANGER: Inhibition of human PC-14 cell growth in a cell viability assay. [AID741809, Type: other]
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12
[SID103515372]
IC50 30.2916SANGER: Inhibition of human SK-N-DZ cell growth in a cell viability assay. [AID741877, Type: other]
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13
[SID103515372]
IC50 32.5Inhibition of Xenopus recombinant Plx1 expressed in Sf21 cells by GST-Cdc25 substrate phosphorylation assay [AID284651, Type: Literature]
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14
[SID103515372]
IC50 37.8956SANGER: Inhibition of human A704 cell growth in a cell viability assay. [AID741956, Type: other]
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15
[SID103515372]
IC50 41.3257SANGER: Inhibition of human EKVX cell growth in a cell viability assay. [AID742143, Type: other]
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16
[SID103515372]
IC50 41.4395SANGER: Inhibition of human SW13 cell growth in a cell viability assay. [AID741900, Type: other]
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17
[SID103515372]
IC50 42.5215SANGER: Inhibition of human BxPC-3 cell growth in a cell viability assay. [AID741990, Type: other]
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18
[SID103515372]
IC50 43.9854SANGER: Inhibition of human EW-7 cell growth in a cell viability assay. [AID742165, Type: other]
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19
[SID103515372]
IC50 44.6703SANGER: Inhibition of human HuO-3N1 cell growth in a cell viability assay. [AID742239, Type: other]
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20
[SID103515372]
IC50 47.0373SANGER: Inhibition of human ES7 cell growth in a cell viability assay. [AID742151, Type: other]
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21
[SID56463197]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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22
[SID14720333]
Compound Screen Assay, Human GEM [AID397, Type: screening]GTP-binding protein GEM [Homo sapiens] [gi:4885263]
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23
[SID103515372]
Antiproliferative activity against prometaphase PTK1 cells assessed as complete arrest at 1 mM within 50 mins [AID284680, Type: Literature]
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24
[SID103515372]
Induction of aberrant monopolar and multipolar spindle formation in human BT20 cells assessed as at 100 uM [AID284681, Type: Literature]
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25
[SID103515372]
Induction of aberrant monopolar and multipolar spindle formation in human U373 cells at 100 uM [AID284682, Type: Literature]
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26
[SID103515372]
Effect on cell division blockade in zebrafish two-cell stage embryo assessed as proliferation arrest at 16-cell stage at 500 uM after 30 to 35 mins [AID284677, Type: Literature]
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27
[SID103515372]
Effect on cell division blockade in zebrafish egg assessed as cell fusion and lysis at 500 uM after 60 mins [AID284678, Type: Literature]
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28
[SID103515372]
Antiproliferative activity against anaphase PTK1 cells assessed as delay in mitosis completion [AID284679, Type: Literature]
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29
[SID103515372]
IC50 50.8175SANGER: Inhibition of human EW-13 cell growth in a cell viability assay. [AID742159, Type: other]
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30
[SID103515372]
IC50 51.4838SANGER: Inhibition of human COLO-741 cell growth in a cell viability assay. [AID742074, Type: other]
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31
[SID103515372]
IC50 53.4206SANGER: Inhibition of human GCT cell growth in a cell viability assay. [AID742176, Type: other]
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32
[SID103515372]
IC50 58.2024SANGER: Inhibition of human HCC1569 cell growth in a cell viability assay. [AID742194, Type: other]
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33
[SID103515372]
IC50 58.7768SANGER: Inhibition of human A4-Fuk cell growth in a cell viability assay. [AID741950, Type: other]
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34
[SID103515372]
IC50 61Inhibition of human PLK3 [AID284658, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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35
[SID103515372]
IC50 61Inhibition of human PLK3 in presence of 25 uM ATP [AID284671, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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36
[SID103515372]
IC50 61Inhibition of Plk3 [AID325653, Type: Literature]
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37
[SID103515372]
IC50 61.4924SANGER: Inhibition of human NCI-H719 cell growth in a cell viability assay. [AID741765, Type: other]
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38
[SID103515372]
IC50 61.8501SANGER: Inhibition of human NCI-H1355 cell growth in a cell viability assay. [AID742405, Type: other]
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39
[SID103515372]
IC50 63.9956SANGER: Inhibition of human KE-37 cell growth in a cell viability assay. [AID742268, Type: other]
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40
[SID103515372]
IC50 64.7665SANGER: Inhibition of human A172 cell growth in a cell viability assay. [AID741942, Type: other]
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41
[SID103515372]
IC50 68.4212SANGER: Inhibition of human SIG-M5 cell growth in a cell viability assay. [AID741858, Type: other]
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42
[SID103515372]
IC50 72.5721SANGER: Inhibition of human SR cell growth in a cell viability assay. [AID741894, Type: other]
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43
[SID103515372]
IC50 73.2147SANGER: Inhibition of human KU-19-19 cell growth in a cell viability assay. [AID742286, Type: other]
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44
[SID103515372]
IC50 74.9335SANGER: Inhibition of human GI-1 cell growth in a cell viability assay. [AID742178, Type: other]
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45
[SID103515372]
IC50 77.2684SANGER: Inhibition of human COLO-679 cell growth in a cell viability assay. [AID742071, Type: other]
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46
[SID103515372]
IC50 78.1601SANGER: Inhibition of human KYSE-180 cell growth in a cell viability assay. [AID742292, Type: other]
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47
[SID103515372]
IC50 78.8706SANGER: Inhibition of human LB1047-RCC cell growth in a cell viability assay. [AID742304, Type: other]
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48
[SID103515372]
IC50 79Inhibition of human PLK3 in presence of 50 uM ATP [AID284672, Type: Literature]Serine/threonine-protein kinase PLK3 [gi:51338822]
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49
[SID103515372]
IC50 79.09SANGER: Inhibition of human A3-KAW cell growth in a cell viability assay. [AID741947, Type: other]
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50
[SID103515372]
IC50 81.9755SANGER: Inhibition of human MDA-MB-231 cell growth in a cell viability assay. [AID742344, Type: other]
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