SMR000111185 (CID 54676686) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(26)
 
 
Inactive(703)
 
 
Inconclusive(33)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
alkPPc(14)
 
 
Bcl-2 like(11)
 
 
7TM GPCR Srsx(10)
 
 
Tryp SPc(8)
 
 
BioAssay Types:
Screening(507)
 
 
 
 
Confirmatory(232)
 
 
 
 
 
Literature(10)
 
 
 
BioActivity Types:
Potency(147)
 
 
 
 
IC50(51)
 
 
 
EC50(17)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 763    Data Row: 763   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID7976488]
EC50 6.341Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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2
[SID7976488]
EC50 8.577Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
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3
[SID7976488]
IC50 8.62Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay [AID624317, Type: confirmatory]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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4
[SID103473020]
IC50 16Inhibition of HIV1 integrase strand transfer activity by PAGE [AID394563, Type: Literature]
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5
[SID103473020]
IC50 16Inhibition of strand transfer catalytic activity HIV1 integrase [AID257141, Type: Literature]Integrase [gi:82312013]
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6
[SID7976488]
EC50 28.584Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
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7
[SID103473020]
IC50 40Inhibition of 3'-processing catalytic activity HIV1 integrase [AID257140, Type: Literature]Integrase [gi:82312013]
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8
[SID103473020]
IC50 40Inhibition of HIV1 integrase 3' processing activity by PAGE [AID394562, Type: Literature]
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9
[SID7976488]
IC50 61.15Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2 [AID651709, Type: confirmatory]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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10
[SID7976488]
 uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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11
[SID7976488]
 Single concentration confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay [AID624309, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
View
12
[SID7976488]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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13
[SID7976488]
 HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]Ddit3 gene product [Mus musculus] [gi:160707929]
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14
[SID7976488]
 Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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15
[SID7976488]
 Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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16
[SID7976488]
 Validation (re-confirmation) assay for identification of compounds that inhibit KCNQ1 potassium channels [AID588353, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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17
[SID7976488]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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18
[SID7976488]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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19
[SID7976488]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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20
[SID7976488]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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21
[SID7976488]
 uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID485273, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
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22
[SID7976488]
 uHTS identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID485273, Type: screening]UBE2N gene product [Homo sapiens] [gi:4507793]
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23
[SID7976488]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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24
[SID7976488]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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25
[SID7976488]
 Primary HTS and Confirmation Assays for S1P1 Agonists and Agonism Potentiators [AID449, Type: screening]S1PR1 gene product [Homo sapiens] [gi:13027636]
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26
[SID7976488]
 Primary HTS and Confirmation Assays for S1P1 Agonists and Agonism Potentiators [AID449, Type: screening]S1PR1 gene product [Homo sapiens] [gi:13027636]
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27
[SID7976488]
 Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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28
[SID7976488]
 Human H69AR Lung Tumor Cell Growth Inhibition Assay [AID580, Type: screening]
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29
[SID7976488]
 Screening for Modulators of Post-Golgi Transport, Control Strain [AID738, Type: screening]
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30
[SID7976488]
 TNFalpha Induced E-Selectin Expression - Primary screen [AID487, Type: screening]
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31
[SID7976488]
 Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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32
[SID7976488]
 Specificity screen against KCNQ1/KCNE1 for identification of compounds that inhibit KCNQ1 potassium channels [AID652147, Type: screening]
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33
[SID7976488]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID7976488]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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35
[SID7976488]
Potency 14.1254qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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36
[SID7976488]
IC50 20Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID493155, Type: confirmatory]UBE2N gene product [Homo sapiens] [gi:4507793]
View
37
[SID7976488]
IC50 20Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay [AID493155, Type: confirmatory]UBE2N gene product [Homo sapiens] [gi:4507793]
View
38
[SID7976488]
EC50 150Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression [AID1914, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
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39
[SID7976488]
 Inhibitors of Y. pestis Topo-I using cleavage product accumulation Measured in Biochemical System Using Plate Reader - 2123-01_Inhibitor_SinglePoint_HTS_Activity [AID504884, Type: screening]DNA topoisomerase I [Yersinia pestis CO92] [gi:115347926]
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40
[SID7976488]
 YopH HTS [AID898, Type: screening]YopH [Yersinia enterocolitica] [gi:28373018]
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41
[SID7976488]
IC50 Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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42
[SID7976488]
 qHTS of Yeast-based Assay for SARS-CoV PLP [AID485353, Type: confirmatory]orf1ab polyprotein (pp1ab) [SARS coronavirus] [gi:30124074]
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43
[SID7976488]
 qHTS of Yeast-based Assay for SARS-CoV PLP [AID485353, Type: confirmatory]orf1ab polyprotein (pp1ab) [SARS coronavirus] [gi:30124074]
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44
[SID7976488]
 qHTS of Yeast-based Assay for SARS-CoV PLP [AID485353, Type: confirmatory]orf1ab polyprotein (pp1ab) [SARS coronavirus] [gi:30124074]
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45
[SID7976488]
 Rtt109/Vps75 Measured in Biochemical System Using Plate Reader - 2106-01_Inhibitor_SinglePoint_HTS_Activity [AID540336, Type: screening]hypothetical protein CaO19.7491 [Candida albicans SC5314] [gi:68474550]
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46
[SID7976488]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID1962, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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47
[SID7976488]
Potency qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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48
[SID7976488]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624268, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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49
[SID7976488]
 HTS assay for inhibitors of Trypanosoma brucei hexokinase 1 [AID1430, Type: screening]hexokinase [Trypanosoma brucei] [gi:70832125]
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50
[SID7976488]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the Epstein-Barr virus nuclear antigen 1 (EBNA-1). [AID1950, Type: screening]EBNA-1 protein [Human herpesvirus 4] [gi:23893623]
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