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BioActivity Data for Compound Acenocoumarol (CID 54676537)

BioActivity Outcomes:
Active(7)
 
 
Inactive(912)
 
 
Inconclusive(14)
 
 
Unspecified(38)
 
 
Top Targets:
7tm 4(46)
 
 
Bcl-2 like(12)
 
 
NR LBD PPAR(12)
 
 
 
 
alkPPc(12)
 
 
Esterase lipa..(8)
 
 
BioAssay Types:
Screening(574)
 
 
 
 
 
Confirmatory(290)
 
 
 
 
 
Literature(57)
 
 
 
 
Summary(29)
 
 
 
 
BioAssay Categories:
In vitro(1)
 
 
In vivo(2)
 
 
 
Biochemical(139)
 
 
 
Toxicity(33)
 
 
 
ADME(13)
 
 
Cell-based(156)
 
 
Organism-base..(15)
 
 
BioActivity Types:
Potency(249)
 
 
 
 
 
IC50(45)
 
 
 
 
EC50(7)
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 886    Data Row: 971   Total Pages: 49   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103532358]
IC50 0.77Inhibition of rat microsomal VKER [AID293981, Type: Literature]
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2
[SID144203981]
Potency-Replicate_1 7.1669qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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3
[SID144203981]
Ratio Potency (uM) 8.35601qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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4
[SID17385821]
Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library) [AID841, Type: screening]
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5
[SID48415501]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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6
[SID17385821]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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7
[SID144203981]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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8
[SID103532358]
Percent relaxation of isolated guinea pig trachea. [AID80631, Type: Literature]
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9
[SID50086853]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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10
[SID103532358]
Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in Pfizer data [AID625295, Type: Literature]
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11
[SID103532358]
Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] [AID1079931, Type: Literature]
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12
[SID103532358]
Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] [AID1079932, Type: Literature]
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13
[SID103532358]
Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is number of references indexed. [column 'AIGUE' in source] [AID1079933, Type: Literature]
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14
[SID103532358]
Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] [AID1079934, Type: Literature]
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15
[SID103532358]
Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] [AID1079935, Type: Literature]
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16
[SID103532358]
Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] [AID1079936, Type: Literature]
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17
[SID103532358]
Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] [AID1079937, Type: Literature]
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18
[SID103532358]
Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] [AID1079938, Type: Literature]
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19
[SID103532358]
Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] [AID1079939, Type: Literature]
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20
[SID103532358]
Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] [AID1079940, Type: Literature]
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