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BioActivity Data for Compound Acenocoumarol (CID 54676537)

BioActivity Outcomes:
Active(7)
 
 
Inactive(906)
 
 
Inconclusive(11)
 
 
Unspecified(38)
 
 
Top Targets:
7tm 4(46)
 
 
Bcl-2 like(12)
 
 
NR LBD PPAR(12)
 
 
 
 
alkPPc(12)
 
 
Esterase lipa..(8)
 
 
BioAssay Types:
Screening(573)
 
 
 
 
 
Confirmatory(285)
 
 
 
 
 
Literature(57)
 
 
 
 
Summary(26)
 
 
 
BioAssay Categories:
In vitro(1)
 
 
In vivo(2)
 
 
 
Biochemical(139)
 
 
 
Toxicity(33)
 
 
 
ADME(13)
 
 
Cell-based(155)
 
 
Organism-base..(15)
 
 
BioActivity Types:
Potency(241)
 
 
 
 
 
IC50(45)
 
 
 
 
EC50(7)
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 877    Data Row: 962   Total Pages: 49   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103532358]
IC50 0.77Inhibition of rat microsomal VKER [AID293981, Type: Literature]
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2
[SID144203981]
Potency-Replicate_1 7.1669qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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3
[SID144203981]
Ratio Potency (uM) 8.35601qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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4
[SID48415501]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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5
[SID17385821]
Non-Nucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity HTS Single Point (MLSMR Library) [AID841, Type: screening]
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6
[SID17385821]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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7
[SID144203981]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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8
[SID103532358]
Percent relaxation using isolated guinea pig trachea. [AID80624, Type: Literature]
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9
[SID103532358]
Percent relaxation of isolated guinea pig trachea. [AID80631, Type: Literature]
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10
[SID103532358]
Displacement of radiolabeled warfarin from fatty acid-free human serum albumin site 1 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy [AID604741, Type: Literature]Serum albumin [gi:113576]
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11
[SID103532358]
Displacement of radiolabeled dansylsarcosine from fatty acid-free human serum albumin site 2 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy [AID604742, Type: Literature]Serum albumin [gi:113576]
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12
[SID103532358]
Displacement of radiolabeled dansylsarcosine from fatty acid containing human serum albumin site 2 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy [AID604744, Type: Literature]Serum albumin [gi:113576]
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13
[SID103532358]
Displacement of radiolabeled warfarin from fatty acid containing human serum albumin site 1 in phosphate buffer at pH 7.4 at 12 uM by fluorescence spectroscopy [AID604743, Type: Literature]Serum albumin [gi:113576]
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14
[SID103532358]
Metabolic stability in human liver microsomes assessed as intrinsic clearance per mg of protein [AID411793, Type: Literature]
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15
[SID103532358]
Volume of distribution at steady state in human at 25 mg, iv [AID419495, Type: Literature]
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16
[SID103532358]
Protein binding in human plasma at 25 mg, iv [AID419496, Type: Literature]
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17
[SID170465636]
AC50 (uM) qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 green channel [AID1117298, Type: confirmatory]
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18
[SID103532358]
Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DILI positive/negative as observed in Pfizer data [AID625295, Type: Literature]
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19
[SID103532358]
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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20
[SID103532358]
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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