Bookmark and Share
Piroxicam (CID 54676228) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(48)
 
 
Inactive(1715)
 
 
Inconclusive(106)
 
 
Unspecified(471)
 
 
Top Targets:
7TM GPCR Srx(51)
 
 
 
 
7TM GPCR Srsx(41)
 
 
 
p450(41)
 
 
 
 
 
NR LBD PPAR(23)
 
 
 
 
NR LBD ER(20)
 
 
 
 
BioAssay Types:
Confirmatory(1021)
 
 
 
 
 
Screening(662)
 
 
 
 
Literature(349)
 
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(733)
 
 
 
 
 
IC50(197)
 
 
 
 
 
EC50(11)
 
 
Ki(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1618    Data Row: 2340   Total Pages: 117   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174787]
IC50 0.1In vitro inhibitory activity against Prostaglandin G/H synthase in rat neutrophils [AID160881, Type: Literature]
View
2
[SID103174787]
IC50 0.1Compound is evaluated for inhibitory effect on the generation of Prostaglandin E2 (PGE2) from rat synovial cells [AID181667, Type: Literature]
View
3
[SID103174787]
ED50 1.3In vivo effective dose required for antiinflammatory activity in rat adjuvant arthritis model [AID177164, Type: Literature]
View
4
[SID103174787]
IC50 1.3Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production (''++'' indicates 80-90% inhibition) [AID161468, Type: Literature]
View
5
[SID103174787]
IC50 1.313DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:317373262]
View
6
[SID11113322]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
View
7
[SID144207349]
Potency-Replicate_1 4.9002qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
8
[SID144203782]
Potency-Replicate_1 5.6929qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
9
[SID11113322]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
View
10
[SID90341008]
Potency 7.0795qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
View
11
[SID144203782]
Ratio Potency (uM) 7.4473qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
View
12
[SID144207349]
Ratio Potency (uM) 9.05493qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
View
13
[SID103174787]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
View
14
[SID103174787]
IC50 10Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
View
15
[SID50103896]
Potency 10qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
View
16
[SID103174787]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
View
17
[SID90341008]
Potency 16.3601qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
View
18
[SID103174787]
IC50 21Tested for inhibitory activity against Prostaglandin G/H synthase 1 from ovine [AID162151, Type: Literature]
View
19
[SID103174787]
IC50 21.33Antiinflammatory activity in human THP1 cells assessed as inhibition of PMA-induced IL-1beta secretion preincubated for 1 hr prior PMA-challenge measured after 48 hrs by ELISA [AID761962, Type: Literature]
View
20
[SID144207349]
Potency-Replicate_1 24.5594qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View