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Piroxicam (CID 54676228) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(44)
 
 
Inactive(1693)
 
 
Inconclusive(111)
 
 
Unspecified(354)
 
 
Top Targets:
7TM GPCR Srx(51)
 
 
 
 
7TM GPCR Srsx(41)
 
 
 
p450(41)
 
 
 
 
 
NR LBD PPAR(23)
 
 
 
 
NR LBD ER(20)
 
 
 
 
BioAssay Types:
Confirmatory(903)
 
 
 
 
 
Screening(660)
 
 
 
 
Literature(316)
 
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(730)
 
 
 
 
 
IC50(195)
 
 
 
 
 
EC50(11)
 
 
Ki(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1498    Data Row: 2202   Total Pages: 45   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103174787]
IC50 0.1Compound is evaluated for inhibitory effect on the generation of Prostaglandin E2 (PGE2) from rat synovial cells [AID181667, Type: Literature]
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2
[SID103174787]
IC50 0.1In vitro inhibitory activity against Prostaglandin G/H synthase in rat neutrophils [AID160881, Type: Literature]
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3
[SID103174787]
ED50 1.3In vivo effective dose required for antiinflammatory activity in rat adjuvant arthritis model [AID177164, Type: Literature]
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4
[SID103174787]
IC50 1.3Concentration of drug that causes a 50% decrease in the maximal inhibition of Prostaglandin G/H synthase 1 activity as measured by PGE-2 production (''++'' indicates 80-90% inhibition) [AID161468, Type: Literature]
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5
[SID103174787]
IC50 1.313DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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6
[SID11113322]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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7
[SID144207349]
Potency-Replicate_1 4.9002qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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8
[SID144203782]
Potency-Replicate_1 5.6929qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID11113322]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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10
[SID90341008]
Potency 7.0795qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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11
[SID144203782]
Ratio Potency (uM) 7.4473qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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12
[SID144207349]
Ratio Potency (uM) 9.05493qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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13
[SID103174787]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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14
[SID103174787]
IC50 10Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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15
[SID50103896]
Potency 10qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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16
[SID103174787]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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17
[SID90341008]
Potency 16.3601qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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18
[SID144207349]
Potency-Replicate_1 17.3867qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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19
[SID103174787]
IC50 21Tested for inhibitory activity against Prostaglandin G/H synthase 1 from ovine [AID162151, Type: Literature]
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20
[SID144207349]
Potency-Replicate_1 24.5594qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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21
[SID11113322]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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22
[SID144207349]
AhR Potency (uM) 32.1281qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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23
[SID50085963]
Potency 35.4813qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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24
[SID856007]
Potency 50.1187qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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25
[SID103174787]
Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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26
[SID11113322]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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27
[SID11113322]
Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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28
[SID103174787]
Cyclooxygenase inhibitor [AID742498, Type: other]Prostaglandin G/H synthase 2 [gi:3915797]
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29
[SID103174787]
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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30
[SID103174787]
Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins [AID678715, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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31
[SID103174787]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins [AID678716, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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32
[SID103174787]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins [AID678717, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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33
[SID103174787]
Cyclooxygenase inhibitor [AID742498, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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34
[SID103174787]
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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35
[SID11113322]
Cytochrome panel assay with activity outcomes [AID1851_2, Type: other]cytochrome P450 2D6 isoform 2 [Homo sapiens] [gi:68509921]
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36
[SID11113322]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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37
[SID11113322]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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38
[SID11111642]
qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral Region [AID593, Type: other]
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39
[SID103174787]
Antiosteoarthritis activity in bovine articular chondrocytes assessed as inhibition of IL1-induced reduction of aggrecan mRNA expression at 0.1 uM after 5 days by Northern blot analysis relative to control [AID472062, Type: Literature]
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40
[SID103174787]
Antiosteoarthritis activity in bovine articular chondrocytes assessed as inhibition of IL1-induced reduction of aggrecan mRNA expression at 1 uM after 5 days by Northern blot analysis relative to control [AID472063, Type: Literature]
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41
[SID103174787]
Antiosteoarthritis activity in bovine articular chondrocytes assessed as inhibition of IL1-induced reduction of aggrecan mRNA expression at 10 uM after 5 days by Northern blot analysis relative to control [AID472064, Type: Literature]
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42
[SID103174787]
Antiinflammatory activity in BALB/C mouse assessed as inhibition of carrageenan-induced paw edema at 20 mg/kg, ip administered 30 mins before carrageenan challenge measured before 48 hrs by plethysmometer [AID510240, Type: Literature]
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43
[SID50085963]
Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Absorbance-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) full deck assay to identify assay artifacts [AID588335, Type: screening]
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44
[SID856007]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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45
[SID103174787]
Ki 4.88TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells [AID678814, Type: other]Solute carrier family 22 member 8 [gi:74730587]
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46
[SID103174787]
Ki 19.8TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT1-expressing S2 cells [AID678821, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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47
[SID103174787]
IC50 20.5TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells [AID681160, Type: other]Solute carrier family 22 member 6 [gi:74762955]
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48
[SID103174787]
Ki 52TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes [AID681340, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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49
[SID103174787]
IC50 65Inhibition of bovine Prostaglandin G/H synthase after oral administration [AID160709, Type: Literature]
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50
[SID103174787]
IC50 100Inhibition of 5-lipoxygenase from rat peritoneal neutrophils after oral administration [AID6865, Type: Literature]
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