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4-hydroxy-12-(trifluoromethyl)-8,9,10,11-tetrahydro-1H-cyclohepta[b]pyrido[2',3':4,5]thieno[3,2-e]pyridin-2(7H)-one (CID 54676162) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(609)
 
 
Inconclusive(13)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
7TM GPCR Srsx(17)
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
Bcl-2 like(6)
 
 
BioAssay Types:
Screening(417)
 
 
 
 
Confirmatory(183)
 
 
 
 
 
Literature(13)
 
 
BioActivity Types:
Potency(134)
 
 
 
 
 
IC50(36)
 
 
EC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 569    Data Row: 626   Total Pages: 32   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24800982]
Potency 2.0787Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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2
[SID24800982]
Potency 16.9441qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID24800982]
MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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4
[SID24800982]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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5
[SID24800982]
Potency 39.8107qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1722, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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6
[SID24800982]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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7
[SID24800982]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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8
[SID24800982]
Profiling compound fluorescence on Avidin Beads with 488 nm excitation and 530 nm emission [AID1775, Type: other]
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9
[SID24800982]
EC50 uHTS identification of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1777, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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10
[SID24800982]
IC50 uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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11
[SID24800982]
IC50 uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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12
[SID24800982]
Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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13
[SID24800982]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1800, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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14
[SID24800982]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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15
[SID24800982]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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16
[SID24800982]
IC50 uHTS identification of small molecule antagonists of the binding of Siah-1 and a peptide ligand via a fluorescence polarization assay. [AID1817, Type: confirmatory]plectin 1 [Homo sapiens] [gi:40849930]
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17
[SID24800982]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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18
[SID24800982]
Luminescence-based counterscreen assay for KLF5 inhibitors: cell-based high throughput screening assay to identify cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1825, Type: screening]
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19
[SID24800982]
MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex-5 [gi:55976631]
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20
[SID24800982]
Fluorescence-based counterscreen assay for HCV NS3 helicase inhibitors: biochemical high-throughput screening assay to identify compounds that cause fluorescent intercalator displacement (FID) [AID1845, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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