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Dicumarol (CID 54676038) - Compound BioActivity Data
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BioActivity Outcomes:
Active(41)
 
 
Inactive(314)
 
 
Inconclusive(72)
 
 
Unspecified(235)
 
 
Top Targets:
7tm 4(33)
 
 
 
p450(21)
 
 
 
 
 
NR LBD ER(9)
 
 
 
 
 
NR LBD AR(8)
 
 
 
 
NR LBD PPAR(8)
 
 
 
 
BioAssay Types:
Confirmatory(355)
 
 
 
 
 
Literature(142)
 
 
 
 
Summary(24)
 
 
 
 
Screening(19)
 
 
BioActivity Types:
Potency(227)
 
 
 
 
 
IC50(135)
 
 
 
 
Ki(4)
 
 
 
EC50(2)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 521    Data Row: 662   Total Pages: 34   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103532383]
IC50 0.0026Inhibition of human recombinant NQO1 [AID441648, Type: Literature]NAD(P)H dehydrogenase [quinone] 1 [gi:118607]
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2
[SID103532383]
IC50 0.005Inhibition of human recombinant NQO1 [AID304251, Type: Literature]NAD(P)H dehydrogenase [quinone] 1 [gi:118607]
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3
[SID11112184]
Potency 0.0251qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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4
[SID103532383]
Ki 0.039Displacement of [3H]PSB-13253 from human recombinant GPR35 exprssed in CHO cells by liquid scintillation counting analysis [AID769725, Type: Literature]G-protein coupled receptor 35 [gi:68068087]
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5
[SID103532383]
IC50 0.3DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: confirmatory]Cytochrome P450 2C9 [gi:6686268]
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6
[SID103532383]
IC50 0.404Inhibition of human recombinant NQO1 in presence of BSA [AID441649, Type: Literature]NAD(P)H dehydrogenase [quinone] 1 [gi:118607]
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7
[SID103532383]
IC50 0.45Inhibition of human recombinant NQO1 in presence of BSA [AID304252, Type: Literature]NAD(P)H dehydrogenase [quinone] 1 [gi:118607]
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8
[SID103532383]
IC50 0.45Inhibition of human recombinant NQO1 [AID277029, Type: Literature]NAD(P)H dehydrogenase [quinone] 1 [gi:118607]
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9
[SID144203908]
Potency-Replicate_1 0.5074qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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10
[SID103532383]
Ki 0.6Binding affinity was measured on Cytochrome P450 2C9 [AID54403, Type: Literature]
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11
[SID144203908]
Potency-Replicate_1 0.6388qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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12
[SID144203908]
Ratio Potency (uM) 1.13588qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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13
[SID103532383]
EC50 1.3Agonist activity at human GPR35 expressed in HEK293T cells at 5 uM by EYPF-based beta-arrestin-2 luciferase reporter gene assay [AID769738, Type: Literature]G-protein coupled receptor 35 [gi:68068087]
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14
[SID103532383]
IC50 1.3Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubated for 1 hr measured after 1 hr at 1 min interval by fluorescence assay [AID610485, Type: Literature]
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15
[SID103532383]
Ki 1.9Binding affinity towards cytochrome P450 2C9 [AID54410, Type: Literature]
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16
[SID144203908]
Ratio Potency (uM) 2.56454qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID103532383]
IC50 3.1Inhibition of rat microsomal VKER [AID293981, Type: Literature]
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18
[SID170465275]
Ratio Potency (uM) 3.61604qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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19
[SID103532383]
IC50 4.093DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) [AID625208, Type: confirmatory]Aldose reductase [gi:1168407]
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20
[SID103532383]
IC50 4.426DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: confirmatory]Mitogen-activated protein kinase 1 [gi:119554]
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