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Enkephalin, Ala(2)-MePhe(4)-Gly(5)- (CID 5462471) - Compound BioActivity Data
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BioActivity Outcomes:
Active(171)
 
 
Inactive(41)
 
 
Inconclusive(22)
 
 
Unspecified(100)
 
 
Top Targets:
7TM GPCR Srx(148)
 
 
 
 
 
7TM GPCR Srsx(16)
 
 
 
 
 
Bromo ALL-1(2)
 
 
Menin(2)
 
 
NR LBD TR(2)
 
 
BioAssay Types:
Literature(300)
 
 
 
 
 
Confirmatory(27)
 
 
 
Screening(5)
 
 
BioActivity Types:
Ki(64)
 
 
 
 
EC50(57)
 
 
 
 
IC50(46)
 
 
 
 
 
Potency(25)
 
 
Kd(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 328    Data Row: 334   Total Pages: 17   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103217856]
AD50 1e-06Analgesic potency in mice after icv injection and 10 min before exposing to hot plate [AID125747, Type: Literature]
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2
[SID103217856]
Ki 2.4e-06Displacement of [3H]DAMGO from mu opioid receptor in Wistar rat brain after 45 mins [AID312059, Type: Literature]Mu-type opioid receptor [gi:464314]
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3
[SID103217856]
Ki 0.00045Displacement of [125I]-IBNalA from MOR-1 expressed in CHO cells [AID603170, Type: Literature]
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4
[SID103217856]
Ki 0.0005Displacement of [3H]DAMGO from human recombinant Opioid receptor mu 1 on CHO cell membranes. [AID150841, Type: Literature]
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5
[SID103217856]
Ki 0.00053Compound was evaluated for the binding affinity of Opioid receptor mu 1 by displacing the radioligand [3H]DAMGO from rat brain membrane [AID151757, Type: Literature]
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6
[SID103217856]
Ki 0.00053Binding affinity for mu opioid receptor [AID152071, Type: Literature]
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7
[SID103217856]
Ki 0.00066Binding affinity against Opioid receptor mu 1 in P2 membrane preparation of rat brain by [3H]DAGO displacement. [AID151758, Type: Literature]
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8
[SID103217856]
IC50 0.00068Binding affinity to human mu-type opioid receptor by radioligand displacement assay [AID751864, Type: Literature]Mu-type opioid receptor [gi:2851402]
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9
[SID103217856]
IC50 0.00074Binding affinity to mu opioid receptor (unknown origin) by radioligand displacement assay [AID752227, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
10
[SID103217856]
Ki 0.00087Displacement of [3H]DAMGO from Sprague-Dawley rat mu opioid receptor by liquid scintillation counting [AID514359, Type: Literature]Mu-type opioid receptor [gi:464314]
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11
[SID103217856]
Ki 0.0009Displacement of [3H]DAMGO from mu opioid receptor (unknown origin) [AID747129, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
12
[SID103217856]
Ki 0.0009Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells by visible spectrophotometry [AID450016, Type: Literature]
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13
[SID103217856]
Ki 0.00099Binding affinity against mu opioid receptor [AID224571, Type: Literature]Mu-type opioid receptor [gi:3024265]
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14
[SID103217856]
EC50 0.001Activation of human mu opioid receptor expressed in HEK293a cells coexpressing YFP-labelled alphai1 and CFP-labelled beta-1-gamma-2 Gi subunits assessed as decrease in fluorescence resonance energy transfer signal at 10 uM [AID327872, Type: Literature]Mu-type opioid receptor [gi:2851402]
View
15
[SID103217856]
EC50 0.001Activation of human mu opioid receptor expressed in HEK293a cells by [35S]GTP-gamma-S binding assay [AID327873, Type: Literature]Mu-type opioid receptor [gi:2851402]
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16
[SID103217856]
IC50 0.00101Displacement of [3H]DAMGO from mu opioid receptor in rat brain [AID450520, Type: Literature]Mu-type opioid receptor [gi:464314]
View
17
[SID103217856]
IC50 0.0011Displacement of radiolabeled DAMGO from human mu-type opioid receptor agonist site [AID346442, Type: Literature]Mu-type opioid receptor [gi:2851402]
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18
[SID103217856]
IC50 0.0011Potency for inhibition of forskolin-stimulated cyclic AMP accumulation in SH-SY5Y cells [AID201472, Type: Literature]
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19
[SID103217856]
Ki 0.0011Displacement of radiolabeled DAMGO from mu opioid receptor in Hartley guinea pig brain [AID268677, Type: Literature]Mu-type opioid receptor [gi:3024265]
View
20
[SID103217856]
IC50 0.00113Displacement of [3H]DAGO from mu opioid receptor in rat brain membrane [AID295476, Type: Literature]Mu-type opioid receptor [gi:464314]
View