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BioActivity Data for Compound Heroin (CID 5462328)

BioActivity Outcomes:
Inactive(63)
 
 
Inconclusive(3)
 
 
Unspecified(7)
 
 
Top Targets:
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD GR(4)
 
 
NR LBD TR(3)
 
 
7tm 4(2)
 
 
BioAssay Types:
Confirmatory(49)
 
 
 
Summary(15)
 
 
 
Literature(7)
 
 
Screening(2)
 
 
BioAssay Categories:
In vitro(1)
 
 
Biochemical(1)
 
 
Toxicity(6)
 
 
ADME(3)
 
 
Cell-based(1)
 
 
BioActivity Types:
Potency(62)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 73    Data Row: 73   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103607696]
Km 6300Activity at human recombinant CES1 expressed in baculovirus-infected Spodoptera frugiperda Sf21 cells assessed as substrate hydrolysis by fluorescence assay [AID456232, Type: Literature]Liver carboxylesterase 1 [gi:119576]
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2
[SID103607696]
Lipophilicity, log P of the compound [AID412236, Type: Literature]
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3
[SID103607696]
Partition coefficient of Zwitterion (logD) [AID19240, Type: Literature]
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4
[SID103607696]
Pharmacokinetic parameter Log D of compound; LogD at pH 7.4 [AID18980, Type: Literature]
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5
[SID103607696]
Pharmacokinetic parameter amine pKa of compound [AID25846, Type: Literature]
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6
[SID103607696]
Partition coefficient of cation (logD) [AID19246, Type: Literature]
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7
[SID103607696]
pKa (acid-base dissociation constant) as determined by Avdeef ref: DOI: 10.1002/047145026X [AID781326, Type: Literature]
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8
[SID144206165]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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9
[SID144206165]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
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10
[SID144206165]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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11
[SID144206165]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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12
[SID144206165]
Potency qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
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13
[SID144206165]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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14
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cell free culture [AID720684, Type: confirmatory]
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15
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free culture [AID720683, Type: confirmatory]
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16
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
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17
[SID144206165]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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18
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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19
[SID144206165]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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20
[SID144206165]
Ratio Potency (uM) qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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