Bookmark and Share

BioActivity Data for Compound Heroin (CID 5462328)

BioActivity Outcomes:
Inactive(63)
 
 
Inconclusive(3)
 
 
Unspecified(7)
 
 
Top Targets:
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
NR LBD GR(4)
 
 
NR LBD TR(3)
 
 
7tm 4(2)
 
 
BioAssay Types:
Confirmatory(49)
 
 
 
Summary(15)
 
 
 
Literature(7)
 
 
Screening(2)
 
 
BioAssay Categories:
In vitro(1)
 
 
Biochemical(1)
 
 
Toxicity(6)
 
 
ADME(3)
 
 
Cell-based(1)
 
 
BioActivity Types:
Potency(62)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 73    Data Row: 73   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103607696]
Km 6300Activity at human recombinant CES1 expressed in baculovirus-infected Spodoptera frugiperda Sf21 cells assessed as substrate hydrolysis by fluorescence assay [AID456232, Type: Literature]Liver carboxylesterase 1 [gi:119576]
View
2
[SID103607696]
Lipophilicity, log P of the compound [AID412236, Type: Literature]
View
3
[SID103607696]
Partition coefficient of cation (logD) [AID19246, Type: Literature]
View
4
[SID103607696]
Pharmacokinetic parameter amine pKa of compound [AID25846, Type: Literature]
View
5
[SID103607696]
Partition coefficient of Zwitterion (logD) [AID19240, Type: Literature]
View
6
[SID103607696]
Pharmacokinetic parameter Log D of compound; LogD at pH 7.4 [AID18980, Type: Literature]
View
7
[SID103607696]
pKa (acid-base dissociation constant) as determined by Avdeef ref: DOI: 10.1002/047145026X [AID781326, Type: Literature]
View
8
[SID144206165]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
View
9
[SID144206165]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
View
10
[SID144206165]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
View
11
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
View
12
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cell free culture [AID720684, Type: confirmatory]
View
13
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free culture [AID720683, Type: confirmatory]
View
14
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell free culture [AID720682, Type: confirmatory]
View
15
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cells [AID720680, Type: confirmatory]
View
16
[SID144206165]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
View
17
[SID144206165]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
View
18
[SID144206165]
ATAD5 Potency (uM) qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
View
19
[SID144206165]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
20
[SID144206165]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View