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Ecdysterone (CID 5459840) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(527)
 
 
Inconclusive(2)
 
 
Unspecified(8)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(12)
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
RasGEF(4)
 
 
BioAssay Types:
Screening(364)
 
 
 
Confirmatory(150)
 
 
 
 
Literature(23)
 
 
 
 
BioActivity Types:
Potency(116)
 
 
 
 
IC50(31)
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 492    Data Row: 541   Total Pages: 28   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103516895]
IC50 0.04571Binding affinity to ecdysone receptor ligand binding domain in Drosophila melanogaster assessed as number of hydrogen bonds formed [AID431525, Type: Literature]Ecdysone receptor [gi:461984]
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2
[SID103516895]
IC50 5.5Binding affinity to Lucilia cuprina recombinant ecdysone receptor ligand binding domain after 3 hrs by fluorescence polarization assay [AID513908, Type: Literature]
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3
[SID103516895]
IC50 24Binding affinity to Bovicola ovis recombinant ecdysone receptor ligand binding domain after 3 hrs by fluorescence polarization assay [AID513909, Type: Literature]
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4
[SID49648767]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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5
[SID103516895]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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6
[SID103516895]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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7
[SID103516895]
Inhibition of human ABCB1 pump expressed in mouse L5178 cells assessed as fluorescence activity ratio at 20 uM for 10 mins by flow cytometry relative to control [AID683076, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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8
[SID103516895]
Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 50% inhibition of cell proliferation at compound-doxorubicin ratio of 20.4:1 after 48 hrs by MTT assay [AID683080, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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9
[SID103516895]
Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 75% inhibition of cell proliferation at compound-doxorubicin ratio of 20.4:1 after 48 hrs by MTT assay [AID683083, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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10
[SID103516895]
Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 95% inhibition of cell proliferation at compound-doxorubicin ratio of 20.4:1 after 48 hrs by MTT assay [AID683086, Type: Literature]Multidrug resistance protein 1 [gi:238054374]
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11
[SID103516895]
Toxicity against larvae of orally dosed Acyrthosiphon pisum Harris [AID286453, Type: Literature]
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12
[SID49648767]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID49648767]
Potency 1.4125A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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14
[SID49648767]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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15
[SID49648767]
Potency 28.1838qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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16
[SID49648767]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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17
[SID93576716]
Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) [AID493087, Type: screening]insulin-degrading enzyme isoform 1 [Homo sapiens] [gi:155969707]
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18
[SID49648767]
Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]protein AF-9 isoform a [Homo sapiens] [gi:156104889]
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19
[SID49648767]
uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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20
[SID49648767]
uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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