Mitoxantrone (CID 5458171) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(195)
 
 
Inactive(302)
 
 
Inconclusive(18)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
7TM GPCR Srsx(6)
 
 
NR LBD VDR(5)
 
 
 
 
PKc like(4)
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(280)
 
 
 
 
Confirmatory(199)
 
 
 
 
 
Literature(13)
 
 
 
 
BioActivity Types:
Potency(86)
 
 
 
 
 
IC50(27)
 
 
 
 
AC50(12)
 
 
 
EC50(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 513    Data Row: 517   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56424031]
Potency 0.0259qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID56424031]
Potency 0.0259qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID56424031]
Potency 0.0259qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID56424031]
Potency 0.0731qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID56424031]
Potency 0.0731qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID56424031]
Potency 0.0731qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID56424031]
EC50 0.1A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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8
[SID103770810]
IC50 0.1Cytotoxicity against doxorubicin-sensitive human MCF7 cells under oxic condition assessed as growth inhibition after 74 hrs by sulforhodamine B assay [AID632891, Type: Literature]
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9
[SID103770810]
IC50 0.1Cytotoxicity against human LoVo cells under oxic condition assessed as growth inhibition after 74 hrs by sulforhodamine B assay [AID632889, Type: Literature]
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10
[SID85273759]
AC50 0.15FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]RAD52 gene product [Homo sapiens] [gi:109637798]
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11
[SID85273759]
AC50 0.535Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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12
[SID85273759]
AC50 0.658Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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13
[SID56424031]
Potency 0.8275Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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14
[SID103770810]
IC50 0.9Cytotoxicity against human LoVo cells under hypoxic condition assessed as growth inhibition after 74 hrs by sulforhodamine B assay [AID632890, Type: Literature]
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15
[SID56424031]
Potency 0.9285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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16
[SID56424031]
Potency 0.9466qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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17
[SID103770810]
IC50 1Cytotoxicity against doxorubicin-sensitive human MCF7 cells under hypoxic condition assessed as growth inhibition after 74 hrs by sulforhodamine B assay [AID632892, Type: Literature]
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18
[SID85273759]
IC50 1.101Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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19
[SID56424031]
Potency 1.122qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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20
[SID56424031]
Potency 1.122qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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21
[SID56424031]
Potency 1.122qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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22
[SID85273759]
AC50 1.336C-LANA Counter Screen: DNA intercalators Measured in Biochemical System Using Plate Reader - 2117-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504727, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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23
[SID85273759]
AC50 1.36224 hour HeLa Cytotox assay Measured in Cell-Based System Using Plate Reader - 2117-03_Inhibitor_Dose_CherryPick_Activity [AID504726, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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24
[SID56424031]
Potency 1.4125qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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25
[SID56424031]
Potency 1.4581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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26
[SID56424031]
Potency 1.4581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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27
[SID56424031]
Potency 1.4581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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28
[SID85273759]
AC50 1.48RAD52: DNA binders Measured in Biochemical System Using Plate Reader - 7018-02_Inhibitor_Dose_CherryPick_Activity [AID652128, Type: confirmatory]
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29
[SID56424031]
IC50 2.23Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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30
[SID56424031]
Potency 2.3109qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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31
[SID56424031]
IC50 4.2Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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32
[SID103770810]
IC50 4.5Displacement of ethidium bromide from DNA by fluorometric analysis [AID632887, Type: Literature]
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33
[SID56424031]
EC50 4.688Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction [AID435023, Type: confirmatory]LANA [Human herpesvirus 8] [gi:139472804]
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34
[SID103770810]
IC50 4.7Cytotoxicity against doxorubicin-resistant human MCF7 cells under oxic condition assessed as growth inhibition after 74 hrs by sulforhodamine B assay [AID632893, Type: Literature]
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35
[SID56424031]
Potency 5.0119qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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36
[SID85273759]
CC50 5.121Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - HeLa Cytotoxicity [AID624300, Type: confirmatory]
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37
[SID56424031]
EC50 5.25Confirmation dose response of hits from high-throughput yeast screen for caloric restriction mimetics that inhibit age-related superoxide [AID449753, Type: confirmatory]
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38
[SID56424031]
EC50 5.882Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2821, Type: confirmatory]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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39
[SID56424031]
EC50 5.882Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2821, Type: confirmatory]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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40
[SID56424031]
EC50 5.882Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2821, Type: confirmatory]serine/threonine-protein kinase 33 [Homo sapiens] [gi:23943882]
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41
[SID56424031]
EC50 6.58Confirmation dose response of additional hit compounds from high-throughput yeast screen for caloric restriction mimetics that inhibit age-related superoxide. [AID504927, Type: confirmatory]
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42
[SID56424031]
Potency 7.9433qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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43
[SID56424031]
Potency 8.9125qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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44
[SID56424031]
Potency 8.9125qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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45
[SID56424031]
Potency 8.9125qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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46
[SID56424031]
Potency 8.9125qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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47
[SID85273759]
AC50 9.515MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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48
[SID85273759]
AC50 9.515MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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49
[SID56424031]
Potency 10HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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50
[SID56424031]
Potency 10.6213qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen [AID602199, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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