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Idazoxan (CID 54459) - Compound BioActivity Data
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BioActivity Outcomes:
Active(103)
 
 
Inactive(195)
 
 
Inconclusive(66)
 
 
Unspecified(115)
 
 
Top Targets:
7TM GPCR Srx(36)
 
 
 
 
 
7TM GPCR Srsx(9)
 
 
 
NR LBD PPAR(8)
 
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
BioAssay Types:
Literature(254)
 
 
 
 
 
Confirmatory(185)
 
 
 
 
Summary(24)
 
 
 
 
Screening(11)
 
 
BioActivity Types:
Potency(195)
 
 
 
 
Kd(33)
 
 
Ki(28)
 
 
IC50(14)
 
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 373    Data Row: 479   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103169925]
Ki 0.0015Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand [AID35902, Type: Literature]
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2
[SID103169925]
Ki 0.00172In vitro binding affinity at Alpha-2 adrenergic receptor in rat cortex by radioligand binding assay using [3H]rauwolscine [AID37375, Type: confirmatory]
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3
[SID103169925]
Kd 0.00229Alpha-2 adrenergic receptor antagonist activity in a rat vas deferens assay. Values ranges from 8.38-8.64 [AID35349, Type: Literature]
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4
[SID103169925]
Kd 0.00275Alpha-2 adrenergic receptor pA2 value against clonidine in vitro experiment in rat vas deferens [AID35340, Type: Literature]
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5
[SID103169925]
Kd 0.00398In vitro reversal of inhibitory effect of UK - 14304 on the contractile response of guinea pig ileum to field stimulation. [AID79507, Type: Literature]
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6
[SID103169925]
Kd 0.00398Ability to reverse inhibitory effects of UK-14304 on the contraction of guinea pig ileum as a measure of alpha-2 adrenergic receptor antagonism. [AID80588, Type: Literature]
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7
[SID103169925]
Ki 0.00427Binding affinity to I2 imidazoline binding site [AID650486, Type: Literature]
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8
[SID103169925]
Kd 0.00513Antagonist potency towards alpha-2 adrenergic receptor in the rat electrically stimulated vas deferens with reference to P-aminoclonidine [AID35357, Type: Literature]
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9
[SID103169925]
Ki 0.00708Displacement of [3H]RS79948-197 from human recombinant adrenergic alpha2A receptor expressed in CHO cells [AID339888, Type: Literature]Alpha-2A adrenergic receptor [gi:1351829]
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10
[SID103169925]
Ki 0.00708Displacement of [3H]RX821002 from human alpha2A adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting [AID650481, Type: Literature]Alpha-2A adrenergic receptor [gi:1351829]
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11
[SID103169925]
Kd 0.00776In vitro antagonistic activity against alpha-2 adrenergic receptor in isolated electrically stimulated rat vas deferens (clonidine-induced decrease in twitch height) [AID218809, Type: Literature]
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12
[SID103169925]
Kd 0.00776In vitro antagonistic activity against alpha-2 adrenergic receptor in isolated electrically stimulated rat vas deferens (clonidine-induced decrease in twitch height) [AID35366, Type: Literature]
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13
[SID103169925]
Kd 0.00776Alpha-2 adrenergic receptor antagonistic activity in rat vas deferens vs clonidin [AID35479, Type: Literature]
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14
[SID103169925]
Ki 0.008Displacement of [3H]MK-912 from adrenergic alpha2A receptor in HT29 cells [AID306189, Type: Literature]
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15
[SID103169925]
IC50 0.00832Binding affinity at human Alpha-2A adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement. [AID36067, Type: Literature]
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16
[SID103169925]
Kd 0.00851Antagonistic activity against presynaptic alpha-2 adrenergic receptor in isolated rat vas deferens using xylazine as agonist [AID35361, Type: Literature]
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17
[SID103169925]
Kd 0.00912Antagonistic activity against alpha-2 adrenergic receptor in rat vas deferens [AID35360, Type: Literature]
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18
[SID103169925]
Kd 0.00912Antagonism of rat alpha-2 adrenergic receptor from rat vas deferens [AID35199, Type: Literature]
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19
[SID103169925]
Kd 0.00977Tested for the alpha-2-adrenoceptor blocking activity by antagonism of clonidine-induced depression of the twitch responses of the field-stimulated prostatic portion of isolated rat vas deferens [AID219799, Type: Literature]Alpha-2C adrenergic receptor [gi:231464]
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20
[SID103169925]
Kd 0.00977Tested for the alpha-2-adrenoceptor blocking activity by antagonism of clonidine-induced depression of the twitch responses of the field-stimulated prostatic portion of isolated rat vas deferens [AID219799, Type: Literature]Alpha-2A adrenergic receptor [gi:231461]
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