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castanospermine (CID 54445) - Compound BioActivity Data
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BioActivity Outcomes:
Active(18)
 
 
Inactive(759)
 
 
Inconclusive(7)
 
 
Unspecified(16)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(20)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
GH31 MGAM SI..(9)
 
 
 
 
BioAssay Types:
Screening(492)
 
 
 
Confirmatory(249)
 
 
 
 
 
Literature(38)
 
 
 
 
BioActivity Types:
Potency(194)
 
 
 
 
 
IC50(44)
 
 
 
EC50(7)
 
 
Ki(2)
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 688    Data Row: 800   Total Pages: 40   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103279132]
Ki 0.1Inhibition of lysosomal alpha-glucosidase [AID617947, Type: Literature]
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2
[SID103279132]
Ki 0.1Inhibition of lysosomal beta-glucosidase [AID617948, Type: Literature]
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3
[SID103279132]
IC50 1Antiviral activity against Dengue virus [AID438025, Type: Literature]
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4
[SID103279132]
IC50 1.1Inhibition of rat liver glucosidase 2 assessed as inhibition of conversion of G1M9 to M9 [AID501842, Type: Literature]
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5
[SID103279132]
IC50 1.3Inhibition of rat liver glucosidase 2 assessed as inhibition of conversion of G2M9 to G1M9 [AID501841, Type: Literature]
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6
[SID11532892]
Potency 1.98qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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7
[SID46393990]
Kd 2.1Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Beta-Glucosidase From Thermotoga Maritima In Complex With Castanospermine [gi:90109092]
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8
[SID26751872]
Potency 3.5481qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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9
[SID11532892]
Potency 5.0119qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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10
[SID103279132]
IC50 7.3Tested for antiviral activity of compound against HIV (Strain GB 8) in JM cells [AID91929, Type: confirmatory]
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11
[SID103279132]
IC50 8Inhibition of Aspergillus niger amyloglucosidase [AID760612, Type: Literature]
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12
[SID103279132]
IC50 8.8Tested for antiviral activity of compound against HIV (Strain GB 8) in JM cells [AID91926, Type: confirmatory]
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13
[SID11532892]
Potency 11.2202qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID1466, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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14
[SID103279132]
IC50 19Inhibition of beta glucosidase (unknown origin) [AID731617, Type: Literature]
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15
[SID103279132]
Tested for antiviral activity of compound against HIV (Strain GB 8) in JM cells [AID91927, Type: other]
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16
[SID103279132]
Inhibition of Aspergillus niger amyloglucosidase by competitive inhibition-based kinetic assay [AID335625, Type: Literature]
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17
[SID103279132]
Antihyperglycemic effect in STZ-diabetic ddY mouse assessed as reduction in blood glucose level at 150 umol/kg, ip after 4 to 6 hrs by glucose oxidase method [AID400362, Type: Literature]
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18
[SID46393990]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: other]Chain A, Beta-Glucosidase From Thermotoga Maritima In Complex With Castanospermine [gi:90109092]
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19
[SID103279132]
Inhibition of Aspergillus niger amyloglucosidase at 7 uM by competitive inhibition-based kinetic assay [AID335627, Type: Literature]
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20
[SID103279132]
Tested for the cytotoxicity against JM cells at 100 uM in an MTT assay [AID91922, Type: other]
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