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castanospermine (CID 54445) - Compound BioActivity Data
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BioActivity Outcomes:
Active(16)
 
 
Inactive(753)
 
 
Inconclusive(7)
 
 
Unspecified(16)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(20)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
GH31 MGAM SI..(9)
 
 
 
 
BioAssay Types:
Screening(492)
 
 
 
Confirmatory(247)
 
 
 
 
 
Literature(31)
 
 
 
 
BioActivity Types:
Potency(194)
 
 
 
 
 
IC50(43)
 
 
 
EC50(7)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 686    Data Row: 792   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103279132]
Ki 0.1Inhibition of lysosomal alpha-glucosidase [AID617947, Type: Literature]
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2
[SID103279132]
Ki 0.1Inhibition of lysosomal beta-glucosidase [AID617948, Type: Literature]
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3
[SID103279132]
IC50 1Antiviral activity against Dengue virus [AID438025, Type: Literature]
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4
[SID103279132]
IC50 1.1Inhibition of rat liver glucosidase 2 assessed as inhibition of conversion of G1M9 to M9 [AID501842, Type: Literature]
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5
[SID103279132]
IC50 1.3Inhibition of rat liver glucosidase 2 assessed as inhibition of conversion of G2M9 to G1M9 [AID501841, Type: Literature]
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6
[SID11532892]
Potency 1.98qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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7
[SID26751872]
Potency 3.5481qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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8
[SID11532892]
Potency 5.0119qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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9
[SID103279132]
IC50 7.3Tested for antiviral activity of compound against HIV (Strain GB 8) in JM cells [AID91929, Type: other]
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10
[SID103279132]
IC50 8.8Tested for antiviral activity of compound against HIV (Strain GB 8) in JM cells [AID91926, Type: other]
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11
[SID11532892]
Potency 11.2202qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID1466, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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12
[SID103279132]
IC50 19Inhibition of beta glucosidase (unknown origin) [AID731617, Type: Literature]
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13
[SID46393990]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Beta-Glucosidase From Thermotoga Maritima In Complex With Castanospermine [gi:90109092]
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14
[SID103279132]
Antihyperglycemic effect in STZ-diabetic ddY mouse assessed as reduction in blood glucose level at 150 umol/kg, ip after 4 to 6 hrs by glucose oxidase method [AID400362, Type: Literature]
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15
[SID103279132]
Tested for antiviral activity of compound against HIV (Strain GB 8) in JM cells [AID91927, Type: other]
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16
[SID103279132]
Inhibition of Aspergillus niger amyloglucosidase by competitive inhibition-based kinetic assay [AID335625, Type: Literature]
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17
[SID103279132]
Inhibition of Aspergillus niger amyloglucosidase at 7 uM by competitive inhibition-based kinetic assay [AID335627, Type: Literature]
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18
[SID103279132]
Increase in light chain 3-GFP+ autophagosome vesicle number per cell in human H4 cells at 13.2 uM after 24 hrs by high throughput fluorescence microscopy relative to control [AID324448, Type: Literature]
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19
[SID103279132]
Increase in light chain 3-GFP+ autophagosome vesicle area per cell in human H4 cells at 13.2 uM after 24 hrs by high throughput fluorescence microscopy relative to control [AID324500, Type: Literature]
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20
[SID103279132]
Increase in light chain 3-GFP+ autophagosome vesicle intensity per cell in human H4 cells at 13.2 uM after 24 hrs by high throughput fluorescence microscopy relative to control [AID324552, Type: Literature]
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21
[SID103279132]
Decrease in FYVE-RFP+ vesicle intensity per cell in human H4 cells after 2 hrs relative to control [AID324579, Type: Literature]
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22
[SID103279132]
Decrease in FYVE-RFP+ vesicle intensity per cell in human H4 cells after 4 hrs relative to control [AID324580, Type: Literature]
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23
[SID103279132]
Decrease in FYVE-RFP+ vesicle intensity per cell in human H4 cells after 8 hrs relative to control [AID324581, Type: Literature]
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24
[SID103279132]
Increase in long-lived protein degradation in human H4 cells after 1 hr relative to control [AID324582, Type: Literature]
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25
[SID103279132]
Increase in long-lived protein degradation in human H4 cells after 2 hrs relative to control [AID324583, Type: Literature]
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26
[SID103279132]
Increase in long-lived protein degradation in human H4 cells after 4 hrs relative to control [AID324584, Type: Literature]
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27
[SID103279132]
Increase in long-lived protein degradation in human H4 cells after 24 hrs relative to control [AID324585, Type: Literature]
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28
[SID103279132]
Induction of light chain 3-GFP level in human H4 cells at 13.2 uM after 24 hrs by high throughput fluorescence microscopy relative to control [AID324396, Type: Literature]
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29
[SID103279132]
Tested for the cytotoxicity against JM cells at 100 uM in an MTT assay [AID91922, Type: other]
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30
[SID103279132]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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31
[SID11532892]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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32
[SID103279132]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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33
[SID26751872]
Potency 0.5623Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2113, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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34
[SID11532892]
Potency 1.2589Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2113, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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35
[SID11532892]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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36
[SID11532892]
Potency 23.1093A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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37
[SID11532892]
Potency 44.6684qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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38
[SID11532892]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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39
[SID11532892]
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity [AID686992, Type: screening]E-selectin precursor [Homo sapiens] [gi:187960042]
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40
[SID11532892]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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41
[SID11532892]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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42
[SID11532892]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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43
[SID26751872]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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44
[SID26751872]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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45
[SID11532892]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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46
[SID11532892]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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47
[SID26751872]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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48
[SID26751872]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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49
[SID11532892]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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50
[SID11532892]
Potency qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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