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tetrahydrozoline (CID 5419) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(78)
 
 
Inconclusive(2)
 
 
Unspecified(22)
 
 
Top Targets:
7TM GPCR Srx(4)
 
 
 
PIKKc TOR(4)
 
 
Pyr redox dim(4)
 
 
Hexokinase 2(3)
 
 
SIS(3)
 
 
BioAssay Types:
Confirmatory(68)
 
 
 
Literature(27)
 
 
 
 
Screening(9)
 
 
BioActivity Types:
Potency(67)
 
 
 
IC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 97    Data Row: 104   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103391481]
IC50 0.03Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain membranes by 50% was reported; 3.0*10e-8 [AID36790, Type: Literature]
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2
[SID103391481]
IC50 1.6Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.2 nM) to rat isolated brain membranes by 50% was reported; 1.6*10e-6 [AID36717, Type: Literature]
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3
[SID103391481]
Hypotensive activity (25% decrease in arterial pressure) after i.v. administration to anesthetized normotensive rats. [AID197167, Type: Literature]
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4
[SID103391481]
Hypertensive activity (increase in arterial pressure to 60 mmHg)) after i.v. administration to pithed rats. [AID197169, Type: Literature]
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5
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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6
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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7
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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8
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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9
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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10
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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11
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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12
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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13
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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14
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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15
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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16
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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17
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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18
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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19
[SID103391481]
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977599, Type: Literature]
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20
[SID103391481]
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM [AID977602, Type: Literature]
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