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tetrahydrozoline (CID 5419) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Inactive(77)
 
 
Inconclusive(2)
 
 
Unspecified(20)
 
 
Top Targets:
7TM GPCR Srx(4)
 
 
 
PIKKc TOR(4)
 
 
Pyr redox dim(4)
 
 
Hexokinase 2(3)
 
 
SIS(3)
 
 
BioAssay Types:
Confirmatory(67)
 
 
 
Literature(25)
 
 
 
 
Screening(9)
 
 
BioActivity Types:
Potency(66)
 
 
 
IC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 94    Data Row: 101   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103391481]
IC50 0.03Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain membranes by 50% was reported; 3.0*10e-8 [AID36790, Type: Literature]
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2
[SID103391481]
IC50 1.6Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit the specific [3H]prazosin binding (0.2 nM) to rat isolated brain membranes by 50% was reported; 1.6*10e-6 [AID36717, Type: Literature]
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3
[SID103391481]
Hypotensive activity (25% decrease in arterial pressure) after i.v. administration to anesthetized normotensive rats. [AID197167, Type: Literature]
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4
[SID103391481]
Hypertensive activity (increase in arterial pressure to 60 mmHg)) after i.v. administration to pithed rats. [AID197169, Type: Literature]
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5
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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6
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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7
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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8
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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9
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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10
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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11
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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12
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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13
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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14
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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15
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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16
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty [AID625290, Type: Literature]
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17
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal [AID625291, Type: Literature]
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18
[SID103391481]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score [AID625292, Type: Literature]
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19
[SID103391481]
Apparent partion coefficient of compound was evaluated in octanol/buffer at pH of 7.4 at 37 degree Centigrade [AID23715, Type: Literature]
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20
[SID103391481]
Partition coefficient (logD7.4) [AID23716, Type: Literature]
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21
[SID103391481]
Central hypotensive activity in anesthetized normotensive rats. [AID33250, Type: Literature]
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22
[SID103391481]
Peripheral hypertensive activity in pithed normotensive rats. [AID33252, Type: Literature]
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23
[SID90341828]
Potency 0.0299Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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24
[SID90341828]
Potency 0.7569qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay [AID720538, Type: confirmatory]arylsulfatase A [Homo sapiens] [gi:220983390]
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25
[SID90341828]
Potency 14.1254qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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26
[SID90341828]
Potency 31.6228qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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27
[SID90341828]
Potency qHTS Validation Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485368, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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28
[SID90341828]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: HTRF assay [AID743207, Type: confirmatory]glucokinase regulatory protein [Homo sapiens] [gi:221625433]
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29
[SID90341828]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: Diaphorase-coupled assay [AID743205, Type: confirmatory]glucokinase regulatory protein [Homo sapiens] [gi:221625433]
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30
[SID90341828]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: ADP-Glo assay [AID743206, Type: confirmatory]glucokinase regulatory protein [Homo sapiens] [gi:221625433]
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31
[SID90341828]
Potency Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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32
[SID90341828]
Potency qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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33
[SID90341828]
Potency qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay [AID493164, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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34
[SID90341828]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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35
[SID90341828]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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36
[SID90341828]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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37
[SID49698620]
IC50 Vibrio cholerae assay for pro-quorum sensing small molecules [AID686977, Type: confirmatory]cyclic AMP receptor protein [Vibrio cholerae O1 biovar El Tor str. N16961] [gi:9657203]
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38
[SID85788488]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of STK33 [AID2330, Type: screening]serine/threonine kinase 33 [Homo sapiens] [gi:12830367]
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39
[SID90341828]
Potency qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2 [AID488837, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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40
[SID90341828]
Potency qHTS Validation Assay for the Inhibitors of DNA Replication in Gram-Positive Bacteria [AID485295, Type: confirmatory]DNA polymerase III [Bacillus subtilis] [gi:30027657]
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41
[SID85788488]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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42
[SID90341828]
Potency qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
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43
[SID90341828]
Potency High-Throughput Screening for Modulators of Cytosolic Chaperonin Activity: MmCpn Primary Screen [AID488978, Type: confirmatory]chaperonin GroEL [Methanococcus maripaludis S2] [gi:45359078]
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44
[SID85788488]
Development of IDH1/2 inhibitors (CTD2project) Measured in Biochemical System Using Plate Reader - 2107-01_Inhibitor_SinglePoint_HTS_Activity [AID624101, Type: screening]Isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens] [gi:62203298]
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45
[SID90341828]
Potency qHTS of Trypanosoma Brucei Inhibitors: LOPAC Validation [AID624147, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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46
[SID90341828]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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47
[SID90341828]
Potency qHTS Validation Assay to Find Inhibitors of Phosphoglycerate Kinase [AID504547, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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48
[SID90341828]
Potency Validation screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493106, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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49
[SID90341828]
Potency Validation screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID493107, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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50
[SID90341828]
Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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