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3,4-Dimethylumbelliferone (CID 5412990) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Unspecified(19)
 
 
Top Targets:
Esterase lipa..(2)
 
 
RHD-n RelA(1)
 
 
17beta-HSD1 l..(1)
 
 
BioAssay Types:
Literature(18)
 
 
 
Confirmatory(2)
 
 
BioActivity Types:
IC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 20    Data Row: 20   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103183840]
IC50 0.21Inhibition of human 17beta-HSD3 expressed in HeLa cells [AID452459, Type: Literature]Testosterone 17-beta-dehydrogenase 3 [gi:1169300]
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2
[SID103183840]
IC50 10In vitro inhibitory against monoamine oxidase A (MAO-A) in rat brain homogenate. [AID125714, Type: confirmatory]
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3
[SID103183840]
IC50 10In vitro inhibitory activity against monoamine oxidase B (MAO-B) in rat brain homogenate. [AID126697, Type: confirmatory]
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4
[SID103183840]
Percent inhibition of monoamine oxidase B at 30 uM [AID127171, Type: Literature]
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5
[SID103183840]
Compound was tested for its inhibitory effect on Monoamine oxidase B at 30 uM [AID127193, Type: Literature]
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6
[SID103183840]
Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production at 10 uM by Griess reaction [AID613464, Type: Literature]
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7
[SID103183840]
Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced NO production at 100 uM by Griess reaction [AID613465, Type: Literature]
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8
[SID103183840]
Inhibition of LPS-stimulated iNOS protein expression in mouse J774 cells at 10 uM by RT-PCR analysis [AID613466, Type: Literature]
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9
[SID103183840]
Inhibition of LPS-stimulated iNOS protein expression in mouse J774 cells at 100 uM by RT-PCR analysis [AID613467, Type: Literature]
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10
[SID103183840]
Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced IL-6 production at 10 uM by ELISA [AID613470, Type: Literature]
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11
[SID103183840]
Antiinflammatory activity in mouse J774 cells assessed as inhibition of LPS-induced IL-6 production at 100 uM by ELISA [AID613471, Type: Literature]
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12
[SID103183840]
Inhibition of LPS-stimulated COX2 protein expression in mouse J774 cells at 10 uM by chemiluminescence assay [AID613472, Type: Literature]
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13
[SID103183840]
Inhibition of LPS-stimulated COX2 protein expression in mouse J774 cells at 100 uM by chemiluminescence assay [AID613473, Type: Literature]
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14
[SID103183840]
Cytotoxicity against mouse J774 cells at 100 uM by XTT assay [AID613474, Type: Literature]
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15
[SID103183840]
Inhibition of LPS-stimulated iNOS mRNA expression in mouse J774 cells by RT-PCR analysis [AID613476, Type: Literature]
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16
[SID103183840]
Inhibition of NF-kB p65 nuclear translocation in LPS-stimulated mouse J774 cells by Western blot analysis [AID613468, Type: Literature]Transcription factor p65 [gi:417926]
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17
[SID103183840]
Inhibitory activity against monoamine oxidase A at 30 uM [AID126199, Type: Literature]
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18
[SID103183840]
Compound was tested for its inhibitory effect on Monoamine oxidase A at 30 uM [AID126340, Type: Literature]
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19
[SID103183840]
Competitive inhibitory activity against acetylcholinesterase (AChE) [AID31007, Type: Literature]Acetylcholinesterase [gi:14916521]
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20
[SID103183840]
Non-competitive inhibitory activity against acetylcholinesterase (AChE) [AID31008, Type: Literature]Acetylcholinesterase [gi:14916521]
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