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Terbutaline (CID 5403) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(79)
 
 
Inconclusive(21)
 
 
Unspecified(344)
 
 
Top Targets:
7TM GPCR Srsx(24)
 
 
 
 
7TM GPCR Srx(21)
 
 
 
p450(8)
 
 
Tryp SPc(4)
 
 
 
Pyr redox dim(4)
 
 
BioAssay Types:
Confirmatory(184)
 
 
 
 
Literature(132)
 
 
 
 
 
Screening(11)
 
 
BioActivity Types:
IC50(133)
 
 
 
 
Potency(67)
 
 
 
Kd(3)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 447    Data Row: 454   Total Pages: 23   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103709193]
Kd 2.51Binding affinity to human adrenergic beta2 receptor [AID426242, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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2
[SID103709193]
Kd 2.51189Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM [AID770362, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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3
[SID103709193]
EC50 3.16228Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr [AID606103, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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4
[SID103709193]
Kd 3.98Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) [AID40694, Type: Literature]
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5
[SID103709193]
Induction of Mitochondrial biogenesis in rabbit RPT cells after 24 hrs by FCCP-OCR assay relative to control [AID770363, Type: Literature]
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6
[SID48414500]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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7
[SID48414500]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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8
[SID48416600]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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9
[SID85209330]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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10
[SID103709193]
Apparent binding affinity constant to beta-2 adrenergic receptor determined using [3H]DHA [AID40687, Type: Literature]Beta-2 adrenergic receptor [gi:2851541]
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11
[SID103709193]
ED50 1.04e+06Compound was tested for effective dose required for 50% of maximum response in guinea pig trachea [AID76656, Type: Literature]
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12
[SID103709193]
Intrinsic activity (n=5) in guinea pig trachea [AID77606, Type: Literature]
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13
[SID103709193]
Intrinsic activity in guinea pig trachea [AID77607, Type: Literature]
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14
[SID103709193]
Binding to POPC (palmitoyl-oleolyl-phosphatidyl-choline) liposomes using biosensor system [AID156089, Type: Literature]
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15
[SID103709193]
Binding to POPC/GMI liposomes using biosensor system [AID156203, Type: Literature]
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16
[SID103709193]
Change in Gibb's free energy at Low affinity beta-2-adrenoceptor in the membranes of bovine skeletal muscle preparation [AID218845, Type: Literature]
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17
[SID103709193]
Change in Gibb's free energy at High affinity beta2- adrenoceptor in Chang living cells. [AID218847, Type: Literature]
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18
[SID103709193]
Change in Gibb's free energy at Low affinity beta-2-adrenoceptor in the Chang living cells [AID218848, Type: Literature]
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19
[SID103709193]
Fraction absorbed in human intestine after oral administration compound was measured [AID236268, Type: Literature]
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20
[SID103709193]
Permeability Coefficient in 2/4/A1 cell model [AID236912, Type: Literature]
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