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BioActivity Data for Compound Terbutaline (CID 5403)

BioActivity Outcomes:
Active(10)
 
 
Inactive(79)
 
 
Inconclusive(21)
 
 
Unspecified(362)
 
 
Top Targets:
7tm 4(43)
 
 
 
 
 
p450(8)
 
 
Tryp SPc(4)
 
 
 
Pyr redox dim(4)
 
 
PIKKc TOR(4)
 
 
BioAssay Types:
Confirmatory(184)
 
 
 
 
Literature(149)
 
 
 
 
 
Screening(11)
 
 
BioAssay Categories:
In vitro(135)
 
 
 
In vivo(124)
 
 
Biochemical(150)
 
 
 
 
Toxicity(128)
 
 
 
ADME(73)
 
 
Cell-based(102)
 
 
 
 
BioActivity Types:
IC50(133)
 
 
 
 
Potency(67)
 
 
 
Kd(3)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 465    Data Row: 472   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103709193]
Kd 2.51Binding affinity to human adrenergic beta2 receptor [AID426242, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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2
[SID103709193]
Kd 2.51189Binding affinity to beta-2 adrenergic receptor (unknown origin) at 1 to 10000 nM [AID770362, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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3
[SID103709193]
EC50 3.16228Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr [AID606103, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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4
[SID103709193]
Kd 3.98Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) [AID40694, Type: Literature]
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5
[SID103709193]
Induction of Mitochondrial biogenesis in rabbit RPT cells after 24 hrs by FCCP-OCR assay relative to control [AID770363, Type: Literature]
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6
[SID85209330]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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7
[SID48416600]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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8
[SID48414500]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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9
[SID48414500]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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10
[SID103709193]
Apparent binding affinity constant to beta-2 adrenergic receptor determined using [3H]DHA [AID40687, Type: Literature]Beta-2 adrenergic receptor [gi:2851541]
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11
[SID103709193]
ED50 1.04e+06Compound was tested for effective dose required for 50% of maximum response in guinea pig trachea [AID76656, Type: Literature]
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12
[SID103709193]
Intrinsic activity (n=5) in guinea pig trachea [AID77606, Type: Literature]
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13
[SID103709193]
Intrinsic activity in guinea pig trachea [AID77607, Type: Literature]
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14
[SID103709193]
Binding to POPC (palmitoyl-oleolyl-phosphatidyl-choline) liposomes using biosensor system [AID156089, Type: Literature]
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15
[SID103709193]
Delta logD (logD6.5 - logD7.4) [AID22293, Type: Literature]
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16
[SID103709193]
Effective permeability measured in human. [AID21264, Type: Literature]
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17
[SID103709193]
Human absorption A (%) [AID20050, Type: Literature]
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18
[SID103709193]
Partition coefficient (logD7.4) [AID19419, Type: Literature]
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19
[SID103709193]
GOF value represents multisets of log P data [AID18861, Type: Literature]
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20
[SID103709193]
Estimation of fraction absorbed (Fa) in the human intestine using biosensor technology. [AID18849, Type: Literature]
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