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AC1NTW5P (CID 5389617) - Compound BioActivity Data
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BioActivity Outcomes:
Active(130)
 
 
Inactive(736)
 
 
Inconclusive(38)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
7TM GPCR Srsx(21)
 
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(9)
 
 
BioAssay Types:
Screening(582)
 
 
 
 
Confirmatory(293)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(172)
 
 
 
 
 
IC50(62)
 
 
 
 
EC50(15)
 
 
 
AC50(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 831    Data Row: 905   Total Pages: 46   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID861727]
IC50_Mean 0.28Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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2
[SID861727]
IC50_Mean 0.77Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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3
[SID861727]
Potency 0.8199A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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4
[SID861727]
Potency 0.8199qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID861727]
Potency 1.1582A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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6
[SID861727]
Potency 1.8349qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [Marburg marburgvirus] [gi:420597]
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7
[SID861727]
EC50 1.92Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
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8
[SID861727]
Potency 1.9953qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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9
[SID861727]
Potency 2.2387qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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10
[SID861727]
Potency 2.3109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID861727]
EC50 2.5Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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12
[SID861727]
IC50 3.072Dose Response Cell Based Assay for Antagonists of the S1P2 Receptor [AID851, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
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13
[SID861727]
AC50_uM 3.28MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_Dose_CherryPick_Activity [AID720514, Type: confirmatory]
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14
[SID861727]
Absolute IC50 (XBP1) 3.44XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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15
[SID861727]
Potency 3.5481qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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16
[SID861727]
IC50 3.707Counterscreen for S1P2 Antagonists: Dose Response Cell-Based Screen to Identify Antagonists of CRE-BLA [AID856, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
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17
[SID861727]
Potency 3.9811qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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18
[SID861727]
AC50_uM 4.09Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 2144-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID720697, Type: confirmatory]
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19
[SID861727]
AC50_uM 4.21Luminescence Cell-Based Counter Screen to Identify Inhibitors of Cytokine Induced Apoptosis [AID463206, Type: confirmatory]
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20
[SID861727]
EC50 4.309Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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