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BioActivity Data for Compound SMR000057767 (CID 5389102)

BioActivity Outcomes:
Active(58)
 
 
Inactive(803)
 
 
Inconclusive(37)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(48)
 
 
 
 
alkPPc(16)
 
 
Tryp SPc(13)
 
 
Bcl-2 like(12)
 
 
PTPc(9)
 
 
BioAssay Types:
Screening(626)
 
 
 
 
 
Confirmatory(237)
 
 
 
 
 
Literature(12)
 
 
BioAssay Categories:
In vitro(2)
 
 
In vivo(1)
 
 
Biochemical(132)
 
 
 
Toxicity(11)
 
 
 
Cell-based(150)
 
 
 
Organism-base..(13)
 
 
BioActivity Types:
Potency(154)
 
 
 
 
 
IC50(51)
 
 
EC50(13)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 827    Data Row: 900   Total Pages: 45   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID857518]
Potency 1.636qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein, partial [Homo sapiens] [gi:116283940]
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2
[SID857518]
Potency 1.6944qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID857518]
EC50 2.197Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response [AID1241, Type: confirmatory]nuclear factor NF-kappa-B p105 subunit isoform 1 [Homo sapiens] [gi:34577122]
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4
[SID857518]
EC50 2.197Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response [AID1241, Type: confirmatory]transcription factor p65 isoform 1 [Homo sapiens] [gi:223468676]
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5
[SID857518]
Potency 7.9433qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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6
[SID857518]
Potency 10qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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7
[SID857518]
Potency 17.7828qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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8
[SID857518]
Potency 39.8107qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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9
[SID857518]
Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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10
[SID857518]
Fluorescence Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the RanGTP-Importin-beta complex [AID2216, Type: screening]
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11
[SID857518]
Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein, partial [Homo sapiens] [gi:257380]
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12
[SID857518]
Pyruvate Kinase [AID361, Type: confirmatory]pyruvate kinase [Geobacillus stearothermophilus] [gi:285623]
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13
[SID857518]
Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID675, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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14
[SID857518]
Counterscreen for activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM): Luminescence-based cell-based high throughput screening assay to identify non-selective compounds using the VP16 reporter assay [AID686939, Type: screening]
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15
[SID857518]
Human A549 Lung Tumor Cell Growth Inhibition Assay [AID371, Type: screening]
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16
[SID857518]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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17
[SID857518]
Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [AID626, Type: screening]
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18
[SID857518]
IL-1B Induced NFkB Translocation - Primary Screen [AID796, Type: screening]
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19
[SID857518]
Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
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20
[SID857518]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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