Vincristine (CID 5388992) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(48)
 
 
Inactive(607)
 
 
Inconclusive(27)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(18)
 
 
Tryp SPc(12)
 
 
alkPPc(8)
 
 
7TM GPCR Srsx(8)
 
 
NR LBD ROR li..(6)
 
 
 
 
BioAssay Types:
Screening(455)
 
 
 
 
 
Confirmatory(204)
 
 
 
 
 
Literature(8)
 
 
BioActivity Types:
Potency(124)
 
 
 
 
 
IC50(42)
 
 
 
 
EC50(16)
 
 
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 682    Data Row: 684   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26663041]
EC50 0.047Luminescence Cell-Based Dose Response to Identify Inhibitors of Luciferase Translation or Activity in H4-C Neuroglioblastoma Cells [AID2458, Type: confirmatory]
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2
[SID26663041]
Potency 0.0517qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling: Hit Validation in Primary Screen [AID651558, Type: confirmatory]
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3
[SID26663041]
EC50 0.055Luminescence Cell-Based HTS Dose Confimation to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID2454, Type: confirmatory]
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4
[SID26663041]
EC50 0.063Luminescence Cell-Based Dose Response to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4-C Neuroglioblastoma Cells [AID2452, Type: confirmatory]
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5
[SID855866]
Potency 0.0631qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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6
[SID855866]
Potency 0.0631qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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7
[SID855866]
Potency 0.0631qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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8
[SID26663041]
EC50 0.1Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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9
[SID26663041]
EC50 0.1Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
View
10
[SID26663041]
EC50 0.1Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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11
[SID49731983]
Potency 0.1458qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID49731983]
Potency 0.1458qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID49731983]
Potency 0.1458qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID26663041]
Potency 0.1472Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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15
[SID49731983]
Potency 0.1836qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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16
[SID26663041]
Potency 0.2617Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
17
[SID49731983]
Potency 0.6513A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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18
[SID26663041]
IC50 3.12Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
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19
[SID49731983]
 Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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20
[SID49731983]
 Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]NR0B1 gene product [Homo sapiens] [gi:5016090]
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21
[SID49731983]
 Luminescence-based cell-based primary high throughput confirmation assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652134, Type: screening]NR0B1 gene product [Homo sapiens] [gi:5016090]
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22
[SID49731983]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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23
[SID49731983]
 ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
View
24
[SID26663041]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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25
[SID26663041]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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26
[SID49731983]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
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27
[SID49731983]
 uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]CFTR gene product [Homo sapiens] [gi:90421313]
View
28
[SID26663041]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
View
29
[SID26663041]
 Single concentration confirmation of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435020, Type: screening]
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30
[SID26663041]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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31
[SID855866]
 Human Lung Fibroblast Proliferation Assay [AID719, Type: screening]
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32
[SID855866]
 Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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33
[SID855866]
 Human A549 Lung Tumor Cell Growth Inhibition Assay [AID371, Type: screening]
View
34
[SID855866]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) [AID431, Type: confirmatory]
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35
[SID855866]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7 cells) [AID430, Type: confirmatory]
View
36
[SID855866]
 Cell Proliferation & Viability (Cytotoxicity) Assay [AID364, Type: confirmatory]
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37
[SID855866]
 Confirmatory screen for Cellular assay for TNF alpha induced NFkappaB translocation [AID462, Type: confirmatory]
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38
[SID855866]
EC50 Fluorescent HTS Cytotoxicity/Cell viability assay (HT1080 cells) [AID620, Type: confirmatory]
View
39
[SID855866]
 Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
40
[SID855866]
 Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
41
[SID855866]
 Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
42
[SID855866]
 Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
43
[SID855866]
 Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
44
[SID855866]
 Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
45
[SID855866]
 Counterscreen for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA): A cell-based dose-response assay for inhibition of the Steroidogenic Factor 1 (SF-1) [AID611, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
46
[SID855866]
 Counterscreen for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA): A cell-based dose-response assay for inhibition of the Steroidogenic Factor 1 (SF-1) [AID611, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
47
[SID855866]
 Counterscreen for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA): A cell-based dose-response assay for inhibition of the Steroidogenic Factor 1 (SF-1) [AID611, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
48
[SID26663041]
IC50 High Throughput Imaging Assay for Beta-Catenin [AID1665, Type: confirmatory]catenin beta-1 [Homo sapiens] [gi:4503131]
View
49
[SID26663041]
IC50 High Throughput Imaging Assay for Beta-Catenin [AID1665, Type: confirmatory]catenin beta-1 [Homo sapiens] [gi:4503131]
View
50
[SID855866]
 Primary Cell Based High Throughput Screening Assay for Antagonists of the 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) [AID571, Type: screening]5-hydroxytryptamine receptor 1E [gi:112822]
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