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Vinblastine (CID 5388983) - Compound BioActivity Data
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BioActivity Outcomes:
Active(175)
 
 
Inactive(724)
 
 
Inconclusive(115)
 
 
Unspecified(19)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(18)
 
 
NR LBD PPAR(16)
 
 
 
 
NR LBD AR(14)
 
 
 
 
NR LBD ER(14)
 
 
 
BioAssay Types:
Screening(517)
 
 
 
 
Confirmatory(355)
 
 
 
 
 
Literature(82)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(314)
 
 
 
 
 
IC50(87)
 
 
 
 
 
EC50(13)
 
 
 
 
AC50(5)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 859    Data Row: 1033   Total Pages: 21   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103496250]
IC50 0.00032Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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2
[SID103496250]
IC50 0.00052Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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3
[SID103496250]
IC50 0.00093Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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4
[SID103496250]
IC50 0.00093Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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5
[SID103496250]
IC50 0.001Antiproliferative activity against human K562 cells after 48 hrs by hemocytometric analysis [AID605844, Type: Literature]
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6
[SID103496250]
IC50 0.001Antiproliferative activity against human K562 cells after 48 hrs by hemocytometer [AID611267, Type: Literature]
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7
[SID103496250]
IC50 0.001Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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8
[SID103496250]
IC50 0.001Antiproliferative activity against human K562 cells after 48 hrs [AID494501, Type: Literature]
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9
[SID103496250]
IC50 0.001Cell growth inhibition of human K562 cells after 48 hrs [AID494520, Type: Literature]
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10
[SID103496250]
IC50 0.001Antiproliferative activity against human K562 cells after 48 hrs [AID347581, Type: Literature]
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11
[SID103496250]
IC50 0.001Antiproliferative activity against human K562 cells after 48 hrs [AID303684, Type: Literature]
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12
[SID103496250]
IC50 0.001Antiproliferative activity against human K562 cell line [AID274784, Type: Literature]
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13
[SID103496250]
IC50 0.001In vitro inhibitory concentration against human chronic myelogenous leukemia K562 cell growth [AID101492, Type: other]
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14
[SID103496250]
IC50 0.00105Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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15
[SID103496250]
IC50 0.00105Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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16
[SID144205051]
Ratio Potency (uM) 0.00771674qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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17
[SID144206288]
Potency-Replicate_1 0.0298qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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18
[SID144206288]
Potency-Replicate_1 0.0298qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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19
[SID56462989]
Potency 0.0366qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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20
[SID144206288]
Ratio Potency (uM) 0.0421632qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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21
[SID144206288]
Potency-Replicate_1 0.0422qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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22
[SID144206288]
Potency-Replicate_1 0.0422qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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23
[SID26663016]
Potency 0.0461qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling: Hit Validation in Primary Screen [AID651558, Type: confirmatory]
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24
[SID144206288]
Potency 0.0473qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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25
[SID144205051]
Potency 0.0517qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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26
[SID144206288]
Potency-Replicate_1 0.0531qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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27
[SID144205051]
Potency-Replicate_1 0.0531qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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28
[SID144205051]
Potency-Replicate_1 0.0531qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
29
[SID144206288]
TR Potency (uM) 0.0595572qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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30
[SID144206288]
Potency 0.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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31
[SID144206288]
Potency-Replicate_1 0.0601qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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32
[SID144205051]
Potency 0.0651qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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33
[SID144205051]
Potency-Replicate_1 0.075qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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34
[SID144205051]
Potency-Replicate_1 0.075qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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35
[SID103496250]
EC50 0.08In vitro concentration required to kill 50% of COLO 320 human colorectal carcinoma cell line [AID52530, Type: Literature]
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36
[SID103496250]
EC50 0.08In vitro concentration required to kill 50% of T47D human breast ductal carcinoma cell line [AID208675, Type: Literature]
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37
[SID56462989]
Potency 0.082qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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38
[SID56462989]
Potency 0.082qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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39
[SID144205051]
Ratio Potency (uM) 0.0916208qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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40
[SID170464976]
Ratio Potency (uM) 0.105901qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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41
[SID144206288]
Ratio Potency (uM) 0.129418qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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42
[SID103496250]
IC50 0.13Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetric assay [AID347582, Type: Literature]
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43
[SID103496250]
IC50 0.13Inhibition of porcine brain tubulin polymerization [AID303685, Type: Literature]
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44
[SID103496250]
IC50 0.13Inhibition of tubulin polymerization in porcine brain [AID274785, Type: Literature]
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45
[SID103496250]
IC50 0.13In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees C [AID159533, Type: Literature]Tubulin alpha-1A chain [gi:135435]
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46
[SID103496250]
IC50 0.13In vitro inhibition of maximum porcine tubulin assembly rate after 20 min at 37 degrees C [AID159533, Type: Literature]Tubulin beta chain [gi:135490]
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47
[SID103496250]
IC50 0.13Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetry [AID494502, Type: Literature]
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48
[SID103496250]
IC50 0.13Inhibition of tubulin polymerization in human K562 cells [AID494521, Type: Literature]
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49
[SID103496250]
IC50 0.13Inhibition of pig brain tubulin polymerization after 30 mins by turbidimetry analysis [AID611278, Type: Literature]
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50
[SID103496250]
IC50 0.13Inhibition of pig tubulin polymerization determined after 45 mins at 37 degC by turbidimetric analysis [AID605956, Type: Literature]
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