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MLS000766149 (CID 5382687) - Compound BioActivity Data
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BioActivity Outcomes:
Active(38)
 
 
Inactive(544)
 
 
Inconclusive(42)
 
 
Unspecified(8)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
 
7TM GPCR Srsx(17)
 
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
ANK(5)
 
 
 
BioAssay Types:
Screening(414)
 
 
 
 
Confirmatory(196)
 
 
 
 
 
Literature(15)
 
 
 
 
 
BioActivity Types:
Potency(140)
 
 
 
 
 
IC50(51)
 
 
 
 
EC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 578    Data Row: 632   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26664809]
AbsAC35_uM 0.00701Counterscreen for inhibitors of NLG for Luciferase Activators Measured in Cell-Based System Using Plate Reader - 2146-03_Inhibitor_Dose_CherryPick_Activity [AID624404, Type: confirmatory]
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2
[SID26664809]
IC50 0.37041Fluorescence-based biochemical high throughput dose response assay for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID652135, Type: confirmatory]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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3
[SID26664809]
IC50 1.056Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis: Fluorescence-based biochemical high throughput Glycerophosphate Dehydrogenase-Triosephosphate Isomerase (GDH-TPI) dose response assay to identify assay artifacts [AID652145, Type: confirmatory]
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4
[SID26664809]
Potency 1.5849qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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5
[SID26664809]
Potency 1.8526Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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6
[SID26664809]
Potency 2.6169Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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7
[SID26664809]
Potency 3.9811VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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8
[SID26664809]
AbsAC26_uM 4.68Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_Dose_CherryPick_Activity [AID624491, Type: confirmatory]
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9
[SID26664809]
Potency 7.5686qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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10
[SID103588845]
IC50 7.8Cytotoxicity against human 769-P cells by MTT assay [AID410375, Type: Literature]
View
11
[SID26664809]
IC50 8.409High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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12
[SID26664809]
Potency 11.5821A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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13
[SID26664809]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID26664809]
Potency 16.3601qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]importin subunit beta-1 isoform 1 [Homo sapiens] [gi:19923142]
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15
[SID26664809]
Potency 16.3601qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]snurportin-1 [Homo sapiens] [gi:5031833]
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16
[SID26664809]
Potency 16.3601qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation [AID540253, Type: confirmatory]GTP-binding nuclear protein Ran [Homo sapiens] [gi:5453555]
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17
[SID26664809]
Potency 19.9526Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
View
18
[SID26664809]
Potency 19.9526qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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19
[SID26664809]
Potency 22.3872qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia [AID485349, Type: confirmatory]serine-protein kinase ATM [Homo sapiens] [gi:71902540]
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20
[SID26664809]
CC50 25.428A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
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21
[SID26664809]
IC50 28.48High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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22
[SID26664809]
IC50 31.15A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
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23
[SID103588845]
IC50 36.7Cytotoxicity against human A549 cells by MTT assay [AID410371, Type: Literature]
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24
[SID103588845]
IC50 37.5Cytotoxicity against human 786-O cells by MTT assay [AID410373, Type: Literature]
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25
[SID26664809]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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26
[SID26664809]
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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27
[SID26664809]
Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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28
[SID26664809]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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29
[SID26664809]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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30
[SID26664809]
uHTS identification of small molecule antagonists of the EBI2 receptor via a luminescent beta-arrestin assay [AID651636, Type: screening]G-protein coupled receptor 183 [Homo sapiens] [gi:4826706]
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31
[SID26664809]
IC50 uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. [AID1434, Type: confirmatory]core-binding factor subunit beta isoform 1 [Homo sapiens] [gi:13124881]
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32
[SID26664809]
Primary Cell-Based Assay to Identify Agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1509, Type: screening]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
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33
[SID26664809]
IC50 uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. [AID1434, Type: confirmatory]runt-related transcription factor 1 isoform AML1c [Homo sapiens] [gi:19923198]
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34
[SID26664809]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
View
35
[SID26664809]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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36
[SID26664809]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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37
[SID26664809]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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38
[SID26664809]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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39
[SID103588845]
IC50 62.9Cytotoxicity against human HT-29 cells by MTT assay [AID410374, Type: Literature]
View
40
[SID103588845]
IC50 71.4Cytotoxicity against human A375 cells by MTT assay [AID410372, Type: Literature]
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41
[SID103588845]
IC50 139Cytotoxicity against human HeLa cells by MTT assay [AID410367, Type: Literature]
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42
[SID103588845]
IC50 171Cytotoxicity against human HepG2 cells by MTT assay [AID410370, Type: Literature]
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43
[SID103588845]
IC50 190Cytotoxicity against human Bel7402 cells by MTT assay [AID410368, Type: Literature]
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44
[SID103588845]
IC50 200Cytotoxicity against human BGC823 cells by MTT assay [AID410369, Type: Literature]
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45
[SID103588845]
IC50 200Cytotoxicity against human KB cells by MTT assay [AID410376, Type: Literature]
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46
[SID26664809]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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47
[SID26664809]
Potency 1qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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48
[SID26664809]
Potency 3.1623qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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49
[SID26664809]
Potency 7.0795qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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50
[SID26664809]
Potency 10qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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