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BioActivity Data for Compound DANS (CID 5377793)

BioActivity Outcomes:
Active(1)
 
 
Inactive(58)
 
 
Inconclusive(27)
 
 
Unspecified(6)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
 
NR LBD ER(7)
 
 
 
 
NR LBD Fxr(4)
 
 
 
NR LBD VDR(4)
 
 
 
BioAssay Types:
Confirmatory(62)
 
 
 
 
Summary(24)
 
 
 
Literature(6)
 
 
BioActivity Types:
Potency(80)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 92    Data Row: 92   Total Pages: 5   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144210116]
Potency-Replicate_1 0.1741qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID103289084]
Carcinogenic activity on all sites after oral administration [AID167928, Type: Literature]
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3
[SID103289084]
Tested for carcinogenic activity on breast after oral administration of the compound; - denotes non carcinogenic activity. [AID167940, Type: Literature]
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4
[SID103289084]
Compound was tested for carcinogenic activity on ear duct after oral administration of the compound; Not available. [AID167952, Type: Literature]
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5
[SID103289084]
Carcinogenic activity on liver after oral administration of the compound [AID168085, Type: Literature]
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6
[SID103289084]
Carcinogenic activity on mixed data after oral administration [AID168100, Type: Literature]
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7
[SID103289084]
Carcinogenic activity after oral administration [AID168112, Type: Literature]
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8
[SID144210116]
Potency-Replicate_1 0.1953qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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9
[SID144210116]
Potency-Replicate_1 0.3504qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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10
[SID144210116]
Potency-Replicate_1 0.4373qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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11
[SID144210116]
Potency-Replicate_1 qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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12
[SID144210116]
Ratio Potency (uM) qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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13
[SID144210116]
Potency-Replicate_1 qHTS assay to test for compound auto fluorescence at 590 nm (red) in HepG2 cells [AID720674, Type: confirmatory]
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14
[SID144210116]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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15
[SID144210116]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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16
[SID144210116]
Potency-Replicate_1 qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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17
[SID144210116]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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18
[SID144210116]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743220, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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19
[SID144210116]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743239, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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20
[SID144210116]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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