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Cefixime (CID 5362065) - Compound BioActivity Data
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BioActivity Outcomes:
Active(64)
 
 
Inactive(363)
 
 
Inconclusive(10)
 
 
Unspecified(264)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
MFS(13)
 
 
7TM GPCR Srsx(12)
 
 
NB-ARC(6)
 
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(307)
 
 
 
Literature(257)
 
 
 
 
Confirmatory(110)
 
 
 
 
 
BioActivity Types:
Potency(91)
 
 
 
 
 
IC50(15)
 
 
 
 
Ki(7)
 
 
EC50(4)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 655    Data Row: 701   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID85148376]
IC50 1.212Counterscreen for inhibitors of phospholipase C isozymes (PLC-B3): Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1) [AID743329, Type: confirmatory]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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2
[SID85148376]
IC50_Mean 1.48Dose response confirmation of uHTS inhibitor hits of SUMO1-mediated protein-protein interactions using a fluorescence resonance energy transfer assay [AID624383, Type: confirmatory]SUMO-1 [Homo sapiens] [gi:1762973]
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3
[SID85148376]
Potency 1.9953qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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4
[SID85148376]
Potency 2.6855Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation [AID504636, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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5
[SID85148376]
Potency 4.1052qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen [AID686980, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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6
[SID85148376]
Potency 4.2562Inhibitors of T. brucei phosphofructokinase: Hit Validation [AID504637, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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7
[SID85148376]
Potency 4.7444qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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8
[SID85148376]
Potency 7.0795qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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9
[SID85148376]
Potency 7.5193qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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10
[SID85148376]
EC50_Mean 9.08Dose Response confirmation of uHTS Activators of the Apaf-1 Pathway in Fluorescent format [AID588554, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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11
[SID85148376]
Potency 11.9173qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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12
[SID85148376]
Potency 12.5893qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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13
[SID85148376]
Potency 14.1254qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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14
[SID85148376]
AC50_uM 17.86MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_Dose_CherryPick_Activity_Set5 [AID720591, Type: confirmatory]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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15
[SID85148376]
Potency 19.0115qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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16
[SID85148376]
Potency 19.9526qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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17
[SID85148376]
Potency 50.1187qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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18
[SID85148376]
Potency 50.1187qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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19
[SID85148376]
MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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20
[SID85148376]
Single concentration confirmation of uHTS Fluorescent assay for identification of activators of Apaf-1 [AID504617, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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21
[SID85148376]
uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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22
[SID85148376]
Counterscreen for inhibitors of phospholipase C isozymes (PLC-B3): Fluorescence-based biochemical high throughput assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1) [AID743258, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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23
[SID85148376]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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24
[SID85148376]
RNA aptamer-based HTS for inhibitors of GRK2 [AID488847, Type: screening]beta-adrenergic receptor kinase 1 [Homo sapiens] [gi:148539876]
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25
[SID85148376]
Fluorescence-based biochemical high throughput confirmation assay to identify inhibitors of phospholipase C isozymes (PLC-B3) [AID743261, Type: screening]Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [gi:148745659]
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26
[SID85148376]
uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]tyrosine-protein phosphatase non-receptor type 5 isoform a [Homo sapiens] [gi:90652859]
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27
[SID85148376]
Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotide [AID720530, Type: screening]E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] [gi:115430235]
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28
[SID85148376]
Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotide [AID687016, Type: screening]E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] [gi:115430235]
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29
[SID103567682]
Bacterial penicillin-binding protein inhibitor [AID742667, Type: other]Penicillin-binding protein 2 [gi:83287775]
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30
[SID103567682]
Bacterial penicillin-binding protein inhibitor [AID742667, Type: other]Peptidoglycan synthase FtsI [gi:83287821]
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31
[SID103567682]
Bacterial penicillin-binding protein inhibitor [AID742667, Type: other]D-alanyl-D-alanine carboxypeptidase DacA [gi:83288472]
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32
[SID85148376]
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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33
[SID103567682]
Bacterial penicillin-binding protein inhibitor [AID742667, Type: other]Penicillin-binding protein 1B [gi:33112644]
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34
[SID85148376]
TRFRET-based biochemical high throughput confirmation assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID720531, Type: screening]Methyl-CpG binding domain protein 2 [Homo sapiens] [gi:21595776]
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35
[SID85148376]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of 5-meCpG-binding domain protein 2 (MBD2)-DBD binding to methylated oligonucleotide [AID686964, Type: screening]Methyl-CpG binding domain protein 2 [Homo sapiens] [gi:21595776]
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36
[SID85148376]
uHTS identification of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay [AID588489, Type: screening]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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37
[SID85148376]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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38
[SID85148376]
uHTS Colorimetric assay for identification of inhibitors of Scp-1 [AID493091, Type: screening]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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39
[SID85148376]
Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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40
[SID85148376]
Absorbance-based bacterial cell-based high throughput confirmation assay to identify inhibitors of RecBCD [AID651982, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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41
[SID85148376]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) [AID651602, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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42
[SID85148376]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) [AID651602, Type: screening]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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43
[SID85148376]
Absorbance-based bacterial cell-based high throughput confirmation assay to identify inhibitors of RecBCD [AID651982, Type: screening]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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44
[SID85148376]
Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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45
[SID85148376]
Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
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46
[SID85148376]
Absorbance-based bacterial cell-based high throughput confirmation assay to identify inhibitors of RecBCD [AID651982, Type: screening]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
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47
[SID85148376]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) [AID651602, Type: screening]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
View
48
[SID85148376]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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49
[SID85148376]
Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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50
[SID85148376]
Counterscreen for RECBCD inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of AddAB recombination protein complex [AID651984, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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