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Butorphanol (CID 5361092) - Compound BioActivity Data
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BioActivity Outcomes:
Active(18)
 
 
Inactive(1)
 
 
Inconclusive(1)
 
 
Unspecified(58)
 
 
Top Targets:
7tm 4(14)
 
 
 
 
p450(6)
 
 
 
BioAssay Types:
Literature(76)
 
 
 
 
 
BioActivity Types:
Ki(9)
 
 
IC50(2)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 78    Data Row: 78   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103205944]
Ki 0.00012Displacement of [3H]DAMGO form human mu opioid receptor expressed in CHO cells [AID410718, Type: Literature]Mu-type opioid receptor [gi:2851402]
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2
[SID103205944]
Ki 0.00012Displacement of [3H]U69593 from human kappa opioid receptor expressed in CHO cell membrane [AID362198, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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3
[SID103205944]
Ki 0.00012Displacement of [3H]U69563 from human kappa-opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID596552, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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4
[SID103205944]
Ki 0.00022Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells [AID410720, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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5
[SID103205944]
Ki 0.00022Displacement of [3H]DAMGO from human mu-opioid receptor expressed in CHO cells after 60 mins by scintillation counting [AID596551, Type: Literature]Mu-type opioid receptor [gi:2851402]
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6
[SID103205944]
Ki 0.00022Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membrane [AID362196, Type: Literature]Mu-type opioid receptor [gi:2851402]
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7
[SID103205944]
EC50 0.0029Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay [AID410731, Type: Literature]Kappa-type opioid receptor [gi:116242691]
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8
[SID103205944]
Ki 0.012Displacement of [3H]Naltindole from human delta opioid receptor expressed in CHO cell membrane [AID362197, Type: Literature]Delta-type opioid receptor [gi:311033488]
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9
[SID103205944]
Ki 0.012Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cells [AID410719, Type: Literature]Delta-type opioid receptor [gi:311033488]
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10
[SID103205944]
Ki 0.012Displacement of [3H]naltrindole from human delta-opioid receptor expressed in CHO cells after 3 hrs by scintillation counting [AID596638, Type: Literature]Delta-type opioid receptor [gi:311033488]
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11
[SID103205944]
IC50 0.014Activity at human cloned mu opioid receptor expressed in CHO cells assessed as inhibition of DAMGO-induced [35S]GTPgammaS binding [AID410730, Type: Literature]Mu-type opioid receptor [gi:2851402]
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12
[SID103205944]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins [AID678716, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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13
[SID103205944]
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins [AID678717, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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14
[SID103205944]
Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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15
[SID103205944]
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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16
[SID103205944]
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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17
[SID103205944]
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis [AID678721, Type: Literature]
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18
[SID48415674]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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19
[SID103205944]
Unbound fraction (plasma) [AID7783, Type: Literature]
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20
[SID103205944]
Observed volume of distribution [AID8002, Type: Literature]
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