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BioActivity Data for Compound Dextrorphan (CID 5360697)

BioActivity Outcomes:
Active(7)
 
 
Inactive(5)
 
 
Unspecified(2)
 
 
Top Targets:
Esterase lipa..(1)
 
 
Firefly Luc l..(1)
 
 
Glutaminase(1)
 
 
PBP1 iGluR NM..(1)
 
 
PBP1 iGluR NM..(1)
 
 
BioAssay Types:
Literature(8)
 
 
 
Confirmatory(5)
 
 
BioAssay Categories:
Biochemical(8)
 
 
 
 
ADME(1)
 
 
Cell-based(2)
 
 
BioActivity Types:
IC50(5)
 
 
Potency(5)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 13    Data Row: 14   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID123086250]
Ki 0.22The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. [AID156805, Type: Literature]
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2
[SID123086250]
IC50 0.246Antagonist activity at NR1/2B receptor expressed in xenopus laevis at pH 6.9 by two electrode voltage clamp method [AID339209, Type: Literature]
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3
[SID123086250]
IC50 1.3Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at pH 7.6 at -40mV holding potential by two-electrode voltage-clamp electrophysiology [AID1124803, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548377]
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4
[SID123086250]
IC50 1.3Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced current at pH 7.6 at -40mV holding potential by two-electrode voltage-clamp electrophysiology [AID1124803, Type: Literature]Glutamate receptor ionotropic, NMDA 2A [gi:14285603]
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5
[SID123086250]
IC50 18Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
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6
[SID123086250]
Displacement of [3H]etorphine from opioid receptor in guinea pig brain homogenate at 10 uM by scintillation counting analysis relative to control [AID1150954, Type: Literature]
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7
[SID123086250]
IC50 Inhibition of electric eel AChE by Ellman's method [AID514203, Type: Literature]Acetylcholinesterase [gi:14916521]
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8
[SID123086250]
Drug level in Homo sapiens (human) whole blood assessed as retention time by UPLC-TOF-MS analysis [AID1097336, Type: other]
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9
[SID123086250]
Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex at 10 uM [AID205268, Type: Literature]
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10
[SID124894243]
Potency Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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11
[SID124894243]
Potency qHTS of GLP-1 Receptor Agonists [AID624172, Type: confirmatory]glp-1 receptor, partial [Homo sapiens] [gi:1724069]
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12
[SID124894243]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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13
[SID124894243]
Potency qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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14
[SID124894243]
Potency qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS [AID602332, Type: confirmatory]heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) [Homo sapiens] [gi:168984549]
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