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Dihydromorphine (CID 5359421) - Compound BioActivity Data
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BioActivity Outcomes:
Active(8)
 
 
Inactive(83)
 
 
Inconclusive(9)
 
 
Unspecified(14)
 
 
Top Targets:
7TM GPCR Srx(11)
 
 
 
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
NR LBD ER(7)
 
 
7TM GPCR Srsx(6)
 
 
 
 
BioAssay Types:
Confirmatory(66)
 
 
 
Summary(24)
 
 
 
Literature(22)
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(84)
 
 
 
Kd(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 102    Data Row: 114   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103556978]
Kd 0.0002Evaluated for Opioid receptor mu 1 affinity against the receptor site model site 1(mu1) [AID151463, Type: Literature]Mu-type opioid receptor [gi:464314]
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2
[SID103556978]
Kd 0.01Opioid receptor mu 2 affinity against the receptor site model site 2(mu2) [AID152211, Type: Literature]Mu-type opioid receptor [gi:464314]
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3
[SID103556978]
Kd 0.1Affinity against the Opioid receptor delta 1 [AID149533, Type: Literature]Delta-type opioid receptor [gi:464311]
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4
[SID103556978]
Kd 0.2Compound was evaluated for opioid receptor affinity against the receptor site model site 5 [AID149052, Type: Literature]Kappa-type opioid receptor [gi:464313]
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5
[SID103556978]
Kd 0.2Compound was evaluated for opioid receptor affinity against the receptor site model site 5 [AID149052, Type: Literature]Mu-type opioid receptor [gi:464314]
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6
[SID103556978]
Kd 0.2Compound was evaluated for opioid receptor affinity against the receptor site model site 5 [AID149052, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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7
[SID103556978]
Kd 0.2Compound was evaluated for opioid receptor affinity against the receptor site model site 5 [AID149052, Type: Literature]Delta-type opioid receptor [gi:464311]
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8
[SID103556978]
Kd 0.83Compound was evaluated for Opioid receptor kappa 1 affinity against the receptor site model site 4(kappa) [AID148456, Type: Literature]
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9
[SID103556978]
Permeability coefficient in human skin [AID311367, Type: Literature]
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10
[SID103556978]
Antinociceptive activity in sc dosed mouse [AID647793, Type: Literature]
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11
[SID103556978]
The ratio between [3H]naloxone binding in the presence and absence of 100 mM NaCl [AID233531, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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12
[SID103556978]
Inhibition of [3H]naloxone receptor binding to opioid receptor in the presence of 100 mM NaCl [AID149050, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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13
[SID103556978]
Inhibition of [3H]naloxone receptor binding to opioid receptor in the absence of 100 mM NaCl [AID149048, Type: Literature]Sigma non-opioid intracellular receptor 1 [gi:81882051]
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14
[SID103556978]
Inhibition of [3H]naloxone receptor binding to opioid receptor in the absence of 100 mM NaCl [AID149048, Type: Literature]Mu-type opioid receptor [gi:464314]
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15
[SID103556978]
Inhibition of [3H]naloxone receptor binding to opioid receptor in the presence of 100 mM NaCl [AID149050, Type: Literature]Mu-type opioid receptor [gi:464314]
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16
[SID103556978]
The ratio between [3H]naloxone binding in the presence and absence of 100 mM NaCl [AID233531, Type: Literature]Mu-type opioid receptor [gi:464314]
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17
[SID103556978]
The ratio between [3H]naloxone binding in the presence and absence of 100 mM NaCl [AID233531, Type: Literature]Delta-type opioid receptor [gi:464311]
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18
[SID103556978]
The ratio between [3H]naloxone binding in the presence and absence of 100 mM NaCl [AID233531, Type: Literature]Kappa-type opioid receptor [gi:464313]
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19
[SID103556978]
Inhibition of [3H]naloxone receptor binding to opioid receptor in the presence of 100 mM NaCl [AID149050, Type: Literature]Kappa-type opioid receptor [gi:464313]
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20
[SID103556978]
Inhibition of [3H]naloxone receptor binding to opioid receptor in the absence of 100 mM NaCl [AID149048, Type: Literature]Kappa-type opioid receptor [gi:464313]
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21
[SID103556978]
Inhibition of [3H]naloxone receptor binding to opioid receptor in the absence of 100 mM NaCl [AID149048, Type: Literature]Delta-type opioid receptor [gi:464311]
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22
[SID103556978]
Inhibition of [3H]naloxone receptor binding to opioid receptor in the presence of 100 mM NaCl [AID149050, Type: Literature]Delta-type opioid receptor [gi:464311]
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23
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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24
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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25
[SID144206439]
Potency qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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26
[SID144206439]
qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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27
[SID144206439]
qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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28
[SID144206439]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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29
[SID144206439]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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30
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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31
[SID144206439]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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32
[SID144206439]
AR Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line: Summary [AID743054, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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33
[SID144206439]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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34
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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35
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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36
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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37
[SID144206439]
Potency-Replicate_1 qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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38
[SID144206439]
Potency-Replicate_1 qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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39
[SID144206439]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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40
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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41
[SID144206439]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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42
[SID144206439]
Potency-Replicate_1 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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43
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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44
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line - cell viability counter screen [AID743041, Type: confirmatory]
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45
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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46
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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47
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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48
[SID144206439]
Potency-Replicate_1 qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
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49
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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50
[SID144206439]
Potency-Replicate_1 qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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