5,7-dihydroxy-4-methylcoumarin (CID 5354284) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(352)
 
 
Inconclusive(36)
 
 
Unspecified(17)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
NR LBD PPAR(5)
 
 
 
7TM GPCR Srsx(5)
 
 
BRLZ(4)
 
 
 
 
NR LBD TR(4)
 
 
 
BioAssay Types:
Confirmatory(201)
 
 
 
 
 
Screening(176)
 
 
 
 
Literature(22)
 
 
 
 
BioActivity Types:
Potency(157)
 
 
 
 
 
IC50(10)
 
 
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 409    Data Row: 417   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID93576743]
Potency 1.636qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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2
[SID17389227]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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3
[SID17389227]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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4
[SID17389227]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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5
[SID17389227]
Potency 7.4978qHTS assay to identify small molecules that stimulate Tumor Necrosis Factor-alpha (TNF-alpha) secretion [AID651757, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
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6
[SID17389227]
Potency 7.4978qHTS assay to identify small molecules that stimulate Tumor Necrosis Factor-alpha (TNF-alpha) secretion [AID651757, Type: confirmatory]TNF gene product [Homo sapiens] [gi:25952111]
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7
[SID17389227]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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8
[SID17389227]
Potency 13.3332qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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9
[SID17389227]
Potency 13.3332qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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10
[SID17389227]
Potency 13.3332qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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11
[SID17389227]
Potency 13.3332qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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12
[SID103173440]
IC50 17Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type) [AID34797, Type: Literature]
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13
[SID103173440]
IC50 34.96Inhibition of CK2 in rat liver [AID317243, Type: Literature]
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14
[SID103173440]
IC50 45.4Inhibition of beta-glucosidase using salicin substrate [AID541494, Type: Literature]
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15
[SID93576743]
 Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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16
[SID93576743]
 Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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17
[SID93576743]
 Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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18
[SID93576743]
 Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]KLK7 gene product [Homo sapiens] [gi:21327705]
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19
[SID93576743]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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20
[SID93576743]
 Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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21
[SID103173440]
IC50 64.61Inhibition of alpha-glucosidase using para-nitrophenyl substrate [AID541338, Type: Literature]
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22
[SID103173440]
IC50 200Inhibition of Aspergillus oryzae Beta-galactosidase [AID541341, Type: Literature]
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23
[SID103173440]
 Inhibition of Aspergillus oryzae Beta-galactosidase at 400 uM [AID541342, Type: Literature]
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24
[SID103173440]
 Antimicrobial activity against Staphylococcus aureus ATCC 25923 by twofold broth dilution method [AID568482, Type: Literature]
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25
[SID103173440]
 Antimicrobial activity against methicillin-resistant Staphylococcus aureus N 315 by twofold broth dilution method [AID568483, Type: Literature]
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26
[SID103173440]
 Antimicrobial activity against Bacillus subtilis ATCC 6633 by twofold broth dilution method [AID568484, Type: Literature]
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27
[SID103173440]
 Antimicrobial activity against Micrococcus luteus ATCC 4698 by twofold broth dilution method [AID568485, Type: Literature]
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28
[SID103173440]
 Antimicrobial activity against Escherichia coli ATCC 25922 by twofold broth dilution method [AID568486, Type: Literature]
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29
[SID103173440]
 Antimicrobial activity against Proteus vulgaris ATCC 6896 by twofold broth dilution method [AID568487, Type: Literature]
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30
[SID103173440]
 Antimicrobial activity against Salmonella typhi ATCC 9484 by twofold broth dilution method [AID568488, Type: Literature]
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31
[SID103173440]
 Antimicrobial activity against Shigella dysenteriae ATCC 49550 by twofold broth dilution method [AID568489, Type: Literature]
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32
[SID103173440]
 Antifungal activity against Candida albicans ATCC 76615 by twofold broth dilution method [AID568490, Type: Literature]
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33
[SID103173440]
 Antifungal activity against Saccharomyces cerevisiae ATCC 9763 by twofold broth dilution method [AID568491, Type: Literature]
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34
[SID103173440]
 Antifungal activity against Aspergillus fumigatus ATCC 96918 by twofold broth dilution method [AID568492, Type: Literature]
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35
[SID17389227]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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36
[SID93576743]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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37
[SID93576743]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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38
[SID103173440]
 Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells at 10 uM [AID458279, Type: Literature]C-C chemokine receptor type 4 [gi:1705894]
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39
[SID17389227]
Potency 6.3096qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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40
[SID17389227]
Potency 6.3096qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
View
41
[SID17389227]
Potency 6.3096qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
View
42
[SID17389227]
Potency 15.8489qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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43
[SID17389227]
Potency 15.8489qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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44
[SID17389227]
Potency 15.8489qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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45
[SID93576743]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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46
[SID93576743]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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47
[SID17389227]
Potency 31.6228qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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48
[SID93576743]
Potency 79.4328qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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49
[SID93576743]
Potency 79.4328qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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50
[SID93576743]
Potency 100qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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