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5,7-dihydroxy-4-methylcoumarin (CID 5354284) - Compound BioActivity Data
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BioActivity Outcomes:
Active(25)
 
 
Inactive(465)
 
 
Inconclusive(70)
 
 
Unspecified(19)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
7TM GPCR Srsx(12)
 
 
 
7TM GPCR Srx(12)
 
 
NR LBD AR(9)
 
 
 
NR LBD ER(9)
 
 
 
BioAssay Types:
Confirmatory(290)
 
 
 
 
 
Screening(220)
 
 
 
 
Literature(27)
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(263)
 
 
 
 
 
IC50(11)
 
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 537    Data Row: 579   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID93576743]
Potency 1.636qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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2
[SID17389227]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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3
[SID17389227]
Potency 7.4978qHTS assay to identify small molecules that stimulate Tumor Necrosis Factor-alpha (TNF-alpha) secretion [AID651757, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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4
[SID17389227]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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5
[SID17389227]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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6
[SID17389227]
Potency 13.3332qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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7
[SID144208080]
Potency-Replicate_1 15.4022qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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8
[SID103173440]
IC50 17Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type) [AID34797, Type: Literature]
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9
[SID144208080]
AhR Potency (uM) 19.3902qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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10
[SID103173440]
IC50 34.96Inhibition of CK2 in rat liver [AID317243, Type: Literature]
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11
[SID144208080]
Potency-Replicate_1 35.4813qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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12
[SID144208080]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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13
[SID144208080]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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14
[SID144208080]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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15
[SID103173440]
IC50 45.4Inhibition of beta-glucosidase using salicin substrate [AID541494, Type: Literature]
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16
[SID144208080]
Potency-Replicate_1 49.158qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743220, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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17
[SID144208080]
Ratio Potency (uM) 51.5919qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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18
[SID144208080]
Potency-Replicate_1 61.3171qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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19
[SID93576743]
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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20
[SID103173440]
Induction of cell differentiation in human U937 cells assessed as increase of CD11b and CD14 expression at 500 uM after 72 hrs by FACS flow cytometer analysis [AID715783, Type: Literature]
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21
[SID93576743]
Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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22
[SID93576743]
Fluorescence Intensity-based biochemical primary high throughput screening assay to identify activators of kallikrein-7 (K7) zymogen [AID652039, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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23
[SID93576743]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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24
[SID93576743]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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25
[SID144208080]
qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720725, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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26
[SID103173440]
IC50 64.61Inhibition of alpha-glucosidase using para-nitrophenyl substrate [AID541338, Type: Literature]
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27
[SID103173440]
IC50 200Inhibition of Aspergillus oryzae Beta-galactosidase [AID541341, Type: Literature]
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28
[SID103173440]
CC50 2000Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay [AID715802, Type: Literature]
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29
[SID103173440]
IC50 2000Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting [AID715803, Type: Literature]
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30
[SID93576743]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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31
[SID103173440]
Displacement of FITC-CKLF1-C27 from human CCR4 receptor expressed in human HEK293 cells at 10 uM [AID458279, Type: Literature]C-C chemokine receptor type 4 [gi:1705894]
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32
[SID103173440]
Inhibition of Aspergillus oryzae Beta-galactosidase at 400 uM [AID541342, Type: Literature]
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33
[SID103173440]
Antimicrobial activity against Staphylococcus aureus ATCC 25923 by twofold broth dilution method [AID568482, Type: Literature]
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34
[SID103173440]
Antimicrobial activity against methicillin-resistant Staphylococcus aureus N 315 by twofold broth dilution method [AID568483, Type: Literature]
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35
[SID103173440]
Antimicrobial activity against Bacillus subtilis ATCC 6633 by twofold broth dilution method [AID568484, Type: Literature]
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36
[SID103173440]
Antimicrobial activity against Micrococcus luteus ATCC 4698 by twofold broth dilution method [AID568485, Type: Literature]
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37
[SID103173440]
Antimicrobial activity against Escherichia coli ATCC 25922 by twofold broth dilution method [AID568486, Type: Literature]
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38
[SID103173440]
Antimicrobial activity against Proteus vulgaris ATCC 6896 by twofold broth dilution method [AID568487, Type: Literature]
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39
[SID103173440]
Antimicrobial activity against Salmonella typhi ATCC 9484 by twofold broth dilution method [AID568488, Type: Literature]
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40
[SID103173440]
Antimicrobial activity against Shigella dysenteriae ATCC 49550 by twofold broth dilution method [AID568489, Type: Literature]
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41
[SID103173440]
Antifungal activity against Candida albicans ATCC 76615 by twofold broth dilution method [AID568490, Type: Literature]
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42
[SID103173440]
Antifungal activity against Saccharomyces cerevisiae ATCC 9763 by twofold broth dilution method [AID568491, Type: Literature]
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43
[SID103173440]
Antifungal activity against Aspergillus fumigatus ATCC 96918 by twofold broth dilution method [AID568492, Type: Literature]
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44
[SID17389227]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
View
45
[SID17389227]
Potency 6.3096qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
View
46
[SID17389227]
Potency 15.8489qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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47
[SID93576743]
Potency 25.1189Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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48
[SID17389227]
Potency 31.6228qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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49
[SID17389227]
Potency 31.6228qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
View
50
[SID144208080]
Potency-Replicate_1 49.158qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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