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5,7-dihydroxy-4-methylcoumarin (CID 5354284) - Compound BioActivity Data
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BioActivity Outcomes:
Active(24)
 
 
Inactive(476)
 
 
Inconclusive(67)
 
 
Unspecified(21)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
7TM GPCR Srx(12)
 
 
7TM GPCR Srsx(12)
 
 
 
NR LBD ER(9)
 
 
 
NR LBD AR(9)
 
 
 
BioAssay Types:
Confirmatory(290)
 
 
 
 
 
Screening(220)
 
 
 
 
Literature(36)
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(264)
 
 
 
 
 
IC50(11)
 
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 539    Data Row: 588   Total Pages: 30   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID93576743]
Potency 1.636qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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2
[SID17389227]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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3
[SID17389227]
Potency 7.4978qHTS assay to identify small molecules that stimulate Tumor Necrosis Factor-alpha (TNF-alpha) secretion [AID651757, Type: confirmatory]tumor necrosis factor [Homo sapiens] [gi:25952111]
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4
[SID17389227]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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5
[SID17389227]
Potency 12.5893qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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6
[SID17389227]
Potency 13.3332qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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7
[SID144208080]
Potency-Replicate_1 15.4022qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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8
[SID103173440]
IC50 17Compound was tested for inhibitory concentration against rat lens aldose reductase (noncompetitive inhibition type) [AID34797, Type: Literature]
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9
[SID144208080]
AhR Potency (uM) 19.3902qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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10
[SID103173440]
IC50 34.96Inhibition of CK2 in rat liver [AID317243, Type: Literature]
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11
[SID144208080]
Potency-Replicate_1 35.4813qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cells [AID720687, Type: confirmatory]
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12
[SID144208080]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HepG2 cell free culture [AID720685, Type: confirmatory]
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13
[SID144208080]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cells [AID720678, Type: confirmatory]
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14
[SID144208080]
Potency-Replicate_1 39.8107qHTS assay to test for compound auto fluorescence at 460 nm (blue) in HEK293 cell free culture [AID720681, Type: confirmatory]
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15
[SID103173440]
IC50 45.4Inhibition of beta-glucosidase using salicin substrate [AID541494, Type: Literature]
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16
[SID144208080]
Ratio Potency (uM) 51.5919qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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17
[SID144208080]
Potency-Replicate_1 61.3171qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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18
[SID93576743]
Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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19
[SID103173440]
Induction of cell differentiation in human U937 cells assessed as increase of CD11b and CD14 expression at 500 uM after 72 hrs by FACS flow cytometer analysis [AID715783, Type: Literature]
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20
[SID93576743]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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