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sulindac sulfide (CID 5352624) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(30)
 
 
Inactive(117)
 
 
Inconclusive(37)
 
 
Unspecified(186)
 
 
Top Targets:
7TM GPCR Srsx(17)
 
 
 
 
7TM GPCR Srx(16)
 
 
 
NR LBD PPAR(12)
 
 
 
 
 
p450(10)
 
 
 
 
prostaglandin..(10)
 
 
 
 
BioAssay Types:
Confirmatory(236)
 
 
 
 
 
Literature(85)
 
 
 
 
Summary(24)
 
 
 
 
Screening(9)
 
 
BioActivity Types:
IC50(138)
 
 
 
 
Potency(127)
 
 
 
 
EC50(10)
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 360    Data Row: 370   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103183701]
IC50 0.05Inhibition of ovine COX1 after 5 mins [AID492859, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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2
[SID103183701]
IC50 0.084DRUGMATRIX: Aldose Reductase enzyme inhibition (substrate: DL-Glyceraldehyde) [AID625208, Type: confirmatory]Aldose reductase [gi:1168407]
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3
[SID103183701]
IC50 0.1Inhibition of human recombinant COX2 after 5 mins [AID492858, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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4
[SID103183701]
IC50 0.115Inhibition of COX1 [AID675695, Type: Literature]
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5
[SID103183701]
IC50 0.14Inhibition of COX2 [AID675696, Type: Literature]
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6
[SID103183701]
IC50 0.688DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: confirmatory]Prostaglandin G/H synthase 1 [gi:317373262]
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7
[SID103183701]
EC50 0.8Agonist activity at PPARgamma expressed in human HCA7 cells assessed as induction of peroxisome proliferator response element after 12 hrs by luciferase reporter assay [AID361858, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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8
[SID103183701]
IC50 1.092DRUGMATRIX: Protein Serine/Threonine Kinase, ERK2 enzyme inhibition (substrate: Myelin Basic Protein) [AID625181, Type: confirmatory]Mitogen-activated protein kinase 1 [gi:119554]
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9
[SID103183701]
IC50 1.537DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) [AID625244, Type: confirmatory]Prostaglandin G/H synthase 2 [gi:3915797]
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10
[SID103183701]
IC50 2DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: confirmatory]Cytochrome P450 1A2 [gi:117144]
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11
[SID144207185]
Ratio Potency (uM) 2.485qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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12
[SID103183701]
Ki 3.5Binding affinity towards human CRTH2 receptor expressed in CHO cells [AID254359, Type: Literature]Prostaglandin D2 receptor 2 [gi:296439334]
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13
[SID103183701]
IC50 7.231DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: confirmatory]Adenosine receptor A3 [gi:1351831]
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14
[SID144207185]
Potency-Replicate_1 9.4392qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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15
[SID144207185]
AhR Potency (uM) 16.1535qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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16
[SID103183701]
IC50 23.981DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: confirmatory]Epidermal growth factor receptor [gi:2811086]
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17
[SID144207185]
Potency-Replicate_1 26.6032qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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18
[SID144207185]
TR Potency (uM) 26.6032qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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19
[SID103183701]
IC50 27.822DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: confirmatory]D(1A) dopamine receptor [gi:118228]
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20
[SID103183701]
IC50 29.368DRUGMATRIX: Cysteinyl leukotriene receptor 1 radioligand binding (ligand: [3H]LTD4) [AID625145, Type: confirmatory]Cysteinyl leukotriene receptor 1 [gi:20138087]
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