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BioActivity Data for Compound Dacarbazine (CID 5351166)

BioActivity Outcomes:
Active(73)
 
 
Inactive(919)
 
 
Inconclusive(70)
 
 
Unspecified(232)
 
 
Top Targets:
7tm 4(66)
 
 
 
p450(25)
 
 
 
 
ANK(8)
 
 
NR LBD TR(8)
 
 
HSD10-like SD..(8)
 
 
BioAssay Types:
Confirmatory(631)
 
 
 
 
 
Screening(324)
 
 
 
Literature(176)
 
 
 
 
 
BioActivity Types:
Potency(359)
 
 
 
 
 
IC50(145)
 
 
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1043    Data Row: 1294   Total Pages: 65   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103168962]
IC50 0.556DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625178, Type: confirmatory]Matrix metalloproteinase-9 [gi:269849668]
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2
[SID57260110]
IC50 4.86High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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3
[SID57260110]
IC50 5.04A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
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4
[SID57260110]
AC50_uM 5.34HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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5
[SID103168962]
IC50 7.67Cytotoxicity against human GC3/C1 cells after 6 days by MTT assay [AID550849, Type: Literature]
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6
[SID103168962]
IC50 11.83Cytotoxicity against human UACC62 cells after 6 days by MTT assay [AID550848, Type: Literature]
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7
[SID103168962]
IC50 14In vitro cytotoxicity against human lymphoblastoid cell (GM892 A) [AID73186, Type: Literature]
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8
[SID103168962]
IC50 17.67Cytotoxicity against human OVCAR3 cells after 6 days by MTT assay [AID550850, Type: Literature]
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9
[SID17389952]
Potency 74.978qHTS assay to identify small molecules that stimulate interleukin-8 (IL-8) secretion [AID651758, Type: confirmatory]interleukin 8 [Homo sapiens] [gi:186368]
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10
[SID103168962]
Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins [AID678712, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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11
[SID57260110]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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12
[SID103168962]
Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins [AID678713, Type: Literature]Cytochrome P450 2C9 [gi:6686268]
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13
[SID57260110]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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14
[SID57260110]
Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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15
[SID57260110]
Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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16
[SID57260110]
Absorbance-based bacterial cell-based high throughput confirmation assay for inhibitors of AddAB recombination protein complex [AID488942, Type: screening]recombination protein RecB [Helicobacter pylori 26695] [gi:15646160]
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17
[SID57260110]
Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), gamma chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130726]
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18
[SID57260110]
Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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19
[SID57260110]
Counterscreen for AddAB inhibitors: absorbance-based high throughput cell-based assay to identify inhibitors of RecBCD [AID488955, Type: screening]exonuclease V (RecBCD complex), beta subunit [Escherichia coli str. K-12 substr. MG1655] [gi:16130724]
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20
[SID103168962]
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins [AID678714, Type: Literature]Cytochrome P450 2C19 [gi:60416369]
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